Smaller left hippocampal subfield CA1 volume is associated with reported childhood physical and/or sexual abuse in major depression: A pilot study
Open accessAbstract
Background Smaller hippocampal volumes are reported in adults with major depressive disorder (MDD) and in reported childhood abuse. The hippocampus is a complex structure with distinct functional subfields. We sought to examine the effect of MDD diagnosis and childhood abuse on hippocampal subfields. Methods Forty-one MDD participants (17 reported abuse and 24 did not) and 46 healthy volunteers (HV) (2 reported abuse) underwent T1- weighted structural magnetic resonance imaging (MRI) and clinical characterization in a retrospective design. A subfield segmentation program was used to measure the whole and subfield hippocampal volumes. Linear mixed-effects models were fitted for group comparisons. Results No main effect of diagnosis interaction effect between diagnosis and subfield region was observed. However, a comparison of abused MDD vs. HVs showed a group by region interaction. A significant interaction between childhood abuse and region was observed. Effects were confined to the left side of the brain, and post hoc, exploratory region-specific tests indicated smaller left CA1 volume in abused MDD compared with non-abused MDD. In addition, smaller amygdala volume was found in all MDD compared with HVs. Limitations We did not have a sample of healthy volunteers with reported childhood abuse. Conclusions The diagnosis of pure MDD may not be sufficient to exert effects on hippocampal volumes, indicating the importance of taking into account childhood trauma in studies on psychopathological mechanisms. Left CA1 might be the hippocampal subfield most relevant to reported childhood abuse. Smaller amygdala volume may be related to MDD diagnosis independent of childhood abuse.
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Major depressive disorder patients who reported being sexually or physically abused showed smaller left CA1 volume than major depressive disorder patients who were not abused.
“For example, MDD patients who reported being sexually or physically abused showed smaller left CA1 volume when compared with MDD patients who were not abused68.”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [68]
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- Authors
- Yuan, M., Rubin-Falcone, H., Lin, X., Rizk, M. M., Miller, J. M., Sublette, M. E., Oquendo, M. A., Burke, A., Ogden, R. T., & Mann, J. J.
- Affiliations
- Sichuan University (CN)
- Columbia University (US)
- New York State Psychiatric Institute (US)
- Corresponding author
- Mann, J. John
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 272
- Pages
- 348-354
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC13108372
- OpenAlex
- W3023822140
- Cited by
- 18
- References
- 55
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- major depressive disorder, child physical abuse, child sexual abuse, hippocampal subfields, amygdala volume, hippocampal subfield segmentation, childhood trauma, brain structure, left hippocampus
- MeSH terms
- Adult, Child, Depression, Major Depressive Disorder, Hippocampus, Humans, Magnetic Resonance Imaging, Organ Size, Pilot Projects, Retrospective Studies, Sex Offenses
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