Cited by 138Schizophrenia research and treatmentBipolar Disorder and TreatmentPsychopathy, Forensic Psychiatry, Sexual Offending

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Persistence or recurrence of non-psychotic comorbid mental disorders associated with 6-year poor functional outcomes in patients at ultra high risk for psychosis

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Rutigliano, Grazia, Valmaggia, Lucia, Landi, Paola, Frascarelli, Marianna, Cappucciati, Marco, Sear, Victoria, Rocchetti, Matteo, De Micheli, Andrea, Jones, Ceri, Palombini, Erika, McGuire, Philip, Fusar-Poli, Paolo·2016·Journal of Affective Disorders

DOI 10.1016/j.jad.2016.05.053

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Abstract

Background Patients at ultra-high risk for psychosis (UHR) are a highly heterogeneous group in terms of clinical and functional outcomes. Several non-psychotic mental disorders co-occur together with the UHR state. Little is known about the impact of non-psychotic comorbid mental disorders on clinical and functional outcomes of UHR patients.Methods The sample included 154 UHR help-seeking patients (identified with the CAARMS, comprehensive assessment of the at-risk mental state), evaluated at baseline on the Ham-D, Ham-A (Hamilton depression/anxiety rating scale), and PANSS (positive and negative syndrome scale). 74 patients completed the 6-year follow-up assessment (mean=6.19, SD=1.87). Comorbid disorders at follow-up were assessed with the SCID I and II. Global functioning was rated on the global assessment of functioning (GAF) scale.Results In the present sample, 6-year risk of psychosis transition was 28.4%. Among non-transitioned UHR patients, 28.3% reported attenuated psychotic symptoms (APS) and 45.3% remained functionally impaired at follow-up (GAF<60). 56.8% patients were affected by at least one comorbid disorder at follow-up. Among UHR patients who presented with some comorbid disorder at baseline, 61.5% had persistent or recurrent course. Incident comorbid disorders emerged in 45.4% of baseline UHR patients. The persistence or recurrence of non-psychotic comorbid mental disorders was associated with poorer global functional outcomes at follow-up.Limitations A substantial proportion of the initial sample was not available for follow-up interviews and some groups in the analyses had small sample size. Predictors of longitudinal outcomes were not explored.Conclusions Among UHR patients, persistence or recurrence of non-psychotic comorbid mental disorders, mostly affective disorders, is associated with 6-year poor functional outcomes.

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Authors: Rutigliano, G., Valmaggia, L., Landi, P., Frascarelli, M., Cappucciati, M., Sear, V., Rocchetti, M., De Micheli, A., Jones, C., Palombini, E., McGuire, P., & Fusar-Poli, P.
Affiliations: University of Pisa (IT)
King's College London (GB)
South London and Maudsley NHS Foundation Trust (GB)
ORCID: Rutigliano, Grazia
Valmaggia, Lucia
Frascarelli, Marianna
Cappucciati, Marco
Rocchetti, Matteo
McGuire, Philip
Venue: Journal of Affective Disorders
Publisher: Elsevier BV
Published: 2016-10
Volume: 203
Pages: 101-110
ISSN: 0165-0327 (ISSN-L)
DOI: 10.1016/j.jad.2016.05.053
OpenAlex: W2417001166
Cited by: 138
References: 69
Citations by year: 2026: 6 · 2025: 6 · 2024: 14 · 2023: 10 · 2022: 13 · 2021: 20 · 2020: 21 · 2019: 21 · 2018: 12 · 2017: 12 · 2016: 3
FWCI: 14.24
Type: journal article
Language: en
Open access: green
kclpure.kcl.ac.uk
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Affective Disorders (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: clinical high risk for psychosis, mood disorders, functional outcome, attenuated psychotic symptoms, global functioning, longitudinal follow-up
MeSH terms: Mental Disorders, Female, Humans, London, Male, Prognosis, Psychiatric Status Rating Scales, Psychotic Disorders, Recurrence, Risk Factors, Comorbidity, Young Adult, Prodromal Symptoms

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Persistence or recurrence of non-psychotic comorbid mental disorders associated with 6-year poor functional outcomes in patients at ultra high risk for psychosis

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