Interaction between job stress and the BDNF Val66Met polymorphism affects depressive symptoms in Chinese healthcare workers
Abstract
Background Chronic exposure to job-related stress can lead to depression and BDNF polymorphism may play an important role in this process. The role of the stress × BDNF Val66Met interaction in depression has been studied widely using childhood stress, but few studies have utilized chronic stress in adulthood as a moderator. This study was to examine the chronic stress × BDNF Val66Met interaction in job-related depression in the healthcare workers in a Chinese Han population, which has not been reported yet.Methods Using a cross-sectional design, 243 doctors and nurses were recruited from a general hospital in Beijing, and were assessed for depression with Self-rating Depression Scale (SDS), and the stress using the House and Rizzo's Work Stress Scale. The BDNF Val66Met polymorphism was genotyped.Results There was a significant positive association between job stress and depressive scores (p < 0.001). No significant main effect of the BDNF Val66Met genotype on depressive symptoms was observed (p > 0.05). A statistically significant interaction between BDNF Val66Met and job stress on depressive symptoms was found (p < 0.05); individuals with Val/Val genotype showed a higher SDS score than Met allele carriers only in the low-stress group, without significant differences in SDS score between the BDNF Val66Met subgroups in medium- or high-stress group.Limitations Limitations include cross-sectional study design, the small sample size only in healthcare workers and only one polymorphism in BDNF gene was analyzed.Conclusions Our results suggest a close relationship between job-related stress and depression, and the interaction of the BDNF Val66Met polymorphism and chronic stress in adulthood may impact the depressive symptoms.
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Research has shown associations between depression and BDNF, candidate SNPs of the BDNF gene, polymorphisms of the BDNF gene, and the interaction of these polymorphisms with other determinants such as stress.
“Research has shown associations between depression and BDNF (as well as candidate SNPs of the BDNF gene, polymorphisms of the BDNF gene, and the interaction of these polymorphisms with other determinants, such as stress) [129,144,145].”
From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [144]
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- Authors
- He, S.-C., Wu, S., Wang, C., Du, X.-D., Yin, G., Jia, Q., Zhang, Y., Wang, L., Soares, J. C., & Zhang, X. Y.
- Affiliations
- Peking University (CN)
- Soochow University (CN)
- Chinese Academy of Sciences (CN)
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Zhang, Yingyang
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 236
- Pages
- 157-163
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2800895067
- Cited by
- 28
- References
- 65
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 3 · 2019: 5
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- Funders
- National Natural Science Foundation of China (81271491, 81571322, 81371477)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Health Professions › General Health Professions › Workplace Health and Well-being
- Keywords
- occupational stress, BDNF Val66Met polymorphism, depressive symptoms, chronic stress, gene-environment interaction, healthcare workers, doctors and nurses, Han Chinese
- MeSH terms
- Occupational Stress, Adolescent, Adult, Alleles, Child, China, Cross-Sectional Studies, Depression, Female, Genotype, Heterozygote, Humans, Male, Middle Aged, Nursing Staff, Hospital, Physicians, Polymorphism, Genetic, Brain-Derived Neurotrophic Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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