Cited by 37Treatment of Major DepressionTranscranial Magnetic Stimulation StudiesCircular RNAs in diseases

Plasma circular RNA DYM related to major depressive disorder and rapid antidepressant effect treated by visual cortical repetitive transcranial magnetic stimulation

Song, Ruize, Bai, Ying, Li, Xianrui, Zhu, Jianli, Zhang, Hongxing, Shi, Yachen, Li, Kun, Wang, Bi +3 more·2020·Journal of Affective Disorders

Abstract

Background Reduced plasma circular RNA DYM (circDYM) has been detected in patients with major depressive disorder (MDD). Mechanism research has demonstrated that circDYM, acting as a microRNA-9 sponge, suppressed microglial activation by increasing Heat Shock Protein 90 ubiquitination, indicating that circDYM could be a potential biomarker of MDD.Methods Thirty-two normal controls (NCs) and 60 MDD patients were recruited. Enrolled patients were randomly allocated to the real or sham repetitive transcranial magnetic stimulation (rTMS) group, followed by continuous five-day visual cortical rTMS or sham treatment. All participants underwent multidimensional neuropsychological assessments and detection of circDYM levels.Results Initial scores on all emotional and psychosocial assessments in MDD were significantly different from those of NCs. As compared with the NC group, baseline plasma circDYM levels in MDD patients decreased remarkably (p=0.030) and showed significant positive correlations with the scores of the 24-item Hamilton Depression Rating Scale (r=0.318, p=0.031) and retardation subscale (r=0.323, p=0.029). The increase in circDYM was noteworthy after rTMS (p=0.006), while downregulation with no statistical significance was observed after sham treatment (p=0.170).Limitations It was not estimated on the correlation between plasma circDYM levels and long-term efficacy of rTMS. The mechanism of upregulated circDYM expression in response to visual cortical rTMS remained unrevealed, and the sample size was relatively small.Conclusions This study verified the reduced circDYM levels in MDD patients, and further determined the upregulated circDYM expression after rTMS treatment, revealing the potential of circDYM as a biomarker for MDD diagnosis and antidepressant effect of visual cortical rTMS.

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Crossref · 10.1016/j.jad.2020.05.109

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  • circDYM is a biomarker for the diagnosis and treatment of depression.

    “Therefore, visual cortical repetitive transcranial magnetic stimulation (rTMS), a noninvasive intervention in depression, may up-regulate circDYM expression to produce anti-depressive effects, further confirming the significant role of circDYM as a biomarker for the diagnosis and treatment of depression [95].”
  • Visual cortical repetitive transcranial magnetic stimulation (rTMS) may up-regulate circDYM expression to produce anti-depressive effects.

    “Therefore, visual cortical repetitive transcranial magnetic stimulation (rTMS), a noninvasive intervention in depression, may up-regulate circDYM expression to produce anti-depressive effects, further confirming the significant role of circDYM as a biomarker for the diagnosis and treatment of depression [95].”

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Authors
Song, R., Bai, Y., Li, X., Zhu, J., Zhang, H., Shi, Y., Li, K., Wang, B., Zhang, H., Yang, Y., & Zhang, Z.
Affiliations
  • Zhongda Hospital Southeast University (CN)
  • Southeast University (CN)
  • Henan Medical University (CN)
Corresponding author
Zhang, Zhijun
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2020-09
Volume
274
Pages
486-493
ISSN
0165-0327 (ISSN-L)
OpenAlex
W3029359867
Cited by
37
References
52
Citations by year
2026: 2 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 8 · 2020: 1
FWCI
3.00
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
Keywords
major depressive disorder, antidepressant effects, biomarkers, microglial activation, depression diagnosis
MeSH terms
RNA, Circular, Antidepressive Agents, Major Depressive Disorder, Depressive Disorder, Major, Humans, Plasma, Treatment Outcome, Transcranial Magnetic Stimulation

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