Cited by 94Transcranial Magnetic Stimulation StudiesElectroconvulsive Therapy StudiesNeurological disorders and treatments

Effectiveness of the prefrontal repetitive transcranial magnetic stimulation on cognitive profiles in depression, schizophrenia, and Alzheimer's disease: A systematic review

Iimori, Takashi, Nakajima, Shinichiro, Miyazaki, Takahiro, Tarumi, Ryosuke, Ogyu, Kamiyu, Wada, Masataka, Tsugawa, Sakiko, Masuda, Fumi +4 more·2019·Progress in Neuro-Psychopharmacology and Biological Psychiatry

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is an effective clinical intervention for various neuropsychiatric diseases. However, it is still unclear whether rTMS has an effect on cognitive functioning. In this review, we aimed to systematically evaluate the cognitive effects of rTMS in depression, schizophrenia, and Alzheimer's disease. We searched PubMed (1996-2018) under the set terms to review randomized controlled trials (RCT) to examine the effectiveness of rTMS administered to the dorsolateral prefrontal cortex (DLPFC) and evaluated cognitive functions in patients with depression, schizophrenia, and Alzheimer's disease. Two authors reviewed each article and came to consensus on the inclusion and exclusion criteria. All eligible studies were reviewed, duplicates were removed, and data were extracted individually. The search identified 579 articles, 31 of which met inclusion and exclusion criteria. Among them, 15 were conducted in patients with depression, 11 in patients with schizophrenia, and 5 in patients with Alzheimer's disease. Specifically, 6 studies demonstrated a significant improvement of executive function across these diseases. Further, no evidence for cognitive adverse effects was found in these included rTMS studies. Although the heterogeneity between studies in terms of cognitive measures applied, stimulation parameters, and participants limits the ability to generalize conclusions, this review demonstrated that prefrontal rTMS could exert pro-cognitive effects on executive function and attention in some patients with depression but inconsistent cognitive impacts in any of the examined domains especially in patients with schizophrenia and Alzheimer's disease. The results warrant further rTMS studies that include systematic assessment of cognition across various neuropsychiatric diseases.

Integrity signals

Registry

Crossref · 10.1016/j.pnpbp.2018.06.014

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Iimori, T., Nakajima, S., Miyazaki, T., Tarumi, R., Ogyu, K., Wada, M., Tsugawa, S., Masuda, F., Daskalakis, Z. J., Blumberger, D. M., Mimura, M., & Noda, Y.
Affiliations
  • Keio University (JP)
  • Centre for Addiction and Mental Health (CA)
Corresponding author
Noda, Yoshihiro
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2019-01
Volume
88
Pages
31-40
ISSN
0278-5846 (ISSN-L)
OpenAlex
W2810028637
Cited by
94
References
79
Citations by year
2026: 5 · 2025: 13 · 2024: 11 · 2023: 16 · 2022: 9 · 2021: 17 · 2020: 13 · 2019: 8 · 2018: 1
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Canadian Institute of Health Research
  • Japan Society for the Promotion of Science
  • Japan Research Foundation for Clinical Pharmacology
  • Naito Foundation
  • Takeda Science Foundation
  • Daiichi Sankyo
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
repetitive transcranial magnetic stimulation, dorsolateral prefrontal cortex, cognitive function, executive function, attention, depression, schizophrenia, Alzheimer's disease, neuropsychiatric disorders, cognitive side effects
MeSH terms
Alzheimer Disease, Cognition Disorders, Depression, Humans, Schizophrenia, Prefrontal Cortex, Transcranial Magnetic Stimulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review