Balance of Unsaturated Fatty Acids Is Important to a Cholesterol-Lowering Diet: Comparison of Mid-Oleic Sunflower Oil and Olive Oil on Cardiovascular Disease Risk Factors

Binkoski, Amy E.; Kris-Etherton, Penny M.; Wilson, Thomas A.; Mountain, Margaret L.; Nicolosi, Robert J.

doi:10.1016/j.jada.2005.04.009

Cited by 93Fatty Acid Research and HealthEdible Oils Quality and AnalysisNuts composition and effects

Balance of Unsaturated Fatty Acids Is Important to a Cholesterol-Lowering Diet: Comparison of Mid-Oleic Sunflower Oil and Olive Oil on Cardiovascular Disease Risk Factors

Binkoski, Amy E., Kris-Etherton, Penny M., Wilson, Thomas A., Mountain, Margaret L., Nicolosi, Robert J.·2005·Journal of the American Dietetic Association

DOI 10.1016/j.jada.2005.04.009

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Abstract

Objective To evaluate the effects of a trans fat-free monounsaturated fatty acid-rich vegetable oil (NuSun sunflower oil, National Sunflower Association, Bismark, ND) that is a good source of polyunsaturated fatty acids (PUFA) and low in saturated fatty acids on lipid and lipoprotein levels and oxidative stress. Design A double-blinded, randomized, three period crossover, controlled feeding study. Subjects/setting Thirty-one men (n=12) and women (n=19) with moderate hypercholesterolemia who were 25 to 64 years of age. Intervention Experimental diets provided 30% fat (olive oil or NuSun sunflower oil contributed one half of the total fat), 8.3% vs 7.9% saturated fatty acid, 17.2% vs 14.2% monounsaturated fatty acid, and 4.3% vs. 7.7% PUFA (olive oil and NuSun sunflower oil, respectively), and 294 mg cholesterol. The control diet was an average American diet (34% fat, 11.2% saturated fatty acid, 14.9% monounsaturated fatty acid, 7.8% PUFA). Subjects consumed each diet for 4 weeks with a 2-week compliance break before crossing over to another diet. Main outcome measures Lipid and lipoprotein levels were measured, and measures of oxidative stress, including lag time, rate of oxidation, total dienes, and lipid hydroperoxides, were assessed. Statistical analysis The mixed model procedure was used to test for main effects of diet, feeding period, and order of diets. Tukey-Kramer adjusted P values were used to determine diet effects. Results The NuSun sunflower oil diet decreased bot…

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Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol; the remaining 18 trials included participants with normal and elevated LDL cholesterol.
“Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol [25,30,33,37,39,47]; the remaining 18 trials included participants with normal and elevated LDL cholesterol.”
From Dietary Polyunsaturated to Saturated Fatty Acid Ratio as an Indicator for LDL Cholesterol Response: A Systematic Review and Meta-Analysis of Randomized Clinical Trials (2025) · cites this paper as [25]

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Authors: Binkoski, A. E., Kris-Etherton, P. M., Wilson, T. A., Mountain, M. L., & Nicolosi, R. J.
Affiliations: Messiah University (US)
University of Massachusetts Lowell (US)
University of Pittsburgh (US)
ORCID: Wilson, Thomas A.
Venue: Journal of the American Dietetic Association
Publisher: Elsevier BV
Published: 2005-07
Volume: 105
Issue: 7
Pages: 1080-1086
ISSN: 0002-8223 (ISSN-L)
DOI: 10.1016/j.jada.2005.04.009
OpenAlex: W1972830635
Cited by: 91
References: 31
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 1 · 2014: 9 · 2013: 3 · 2012: 3
FWCI: 4.57
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of the American Dietetic Association (publishedVersion)
PubMed (publishedVersion)
Funders: National Center for Research Resources (M01 RR10732, M01RR010732)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
Keywords: unsaturated fatty acids, olive oil, hypercholesterolemia, LDL cholesterol, total cholesterol, monounsaturated fatty acids, polyunsaturated fatty acids, saturated fatty acids, dietary fat composition, oxidative stress, lipid oxidation, lipid hydroperoxides, alpha-tocopherol, cardiovascular risk factors, cholesterol-lowering diet
MeSH terms: Olive Oil, Sunflower Oil, Adult, Cardiovascular Diseases, Cholesterol, Dietary Fats, Unsaturated, Double-Blind Method, Female, Humans, Hypercholesterolemia, Cholesterol, LDL, Male, Middle Aged, Oxidation-Reduction, Plant Oils, Risk Factors, Lipid Peroxidation, Oxidative Stress, Cross-Over Studies, Oleic Acid

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Balance of Unsaturated Fatty Acids Is Important to a Cholesterol-Lowering Diet: Comparison of Mid-Oleic Sunflower Oil and Olive Oil on Cardiovascular Disease Risk Factors

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