Early-life home environment and risk of asthma among inner-city children
Open accessAbstract
Background Environmental exposures in early life appear to play an important role in the pathogenesis of childhood asthma, but the potentially modifiable exposures that lead to asthma remain uncertain.Objective We sought to identify early-life environmental risk factors for childhood asthma in a birth cohort of high-risk inner-city children.Methods We examined the relationship of prenatal and early-life environmental factors to the occurrence of asthma at 7 years of age among 442 children.Results Higher house dust concentrations of cockroach, mouse, and cat allergens in the first 3 years of life were associated with lower risk of asthma (for cockroach allergen: odds ratio per interquartile range increase in concentration, 0.55; 95% CI, 0.36-0.86; P < .01). House dust microbiome analysis using 16S ribosomal RNA sequencing identified 202 and 171 bacterial taxa that were significantly (false discovery rate < 0.05) more or less abundant, respectively, in the homes of children with asthma. A majority of these bacteria were significantly correlated with 1 of more allergen concentrations. Other factors associated significantly positively with asthma included umbilical cord plasma cotinine concentration (odds ratio per geometric SD increase in concentration, 1.76; 95% CI, 1.00-3.09; P = .048) and maternal stress and depression scores.Conclusion Among high-risk inner-city children, higher indoor levels of pet or pest allergens in infancy were associated with lower risk of asthma. The abundance of a number of bacterial taxa in house dust was associated with increased or decreased asthma risk. Prenatal tobacco smoke exposure and higher maternal stress and depression scores in early life were associated with increased asthma risk.
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The role of early-life allergen exposure in the development of asthma has been widely studied, with mixed results.
“The role of early-life allergen exposure in the development of asthma has been widely studied, with mixed results (63).”
From Indoor Allergen Interventions in Homes and Schools for Managing Asthma (2025) · cites this paper as [63]
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- Authors
- O'Connor, G. T., Lynch, S. V., Bloomberg, G. R., Kattan, M., Wood, R. A., Gergen, P. J., Jaffee, K. F., Calatroni, A., Bacharier, L. B., Beigelman, A., Sandel, M. T., Johnson, C. C., Faruqi, A., Santee, C., Fujimura, K. E., Fadrosh, D., Boushey, H., Visness, C. M., & Gern, J. E.
- Affiliations
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Columbia University (US)
- Johns Hopkins University (US)
- National Institute of Allergy and Infectious Diseases (US)
- Rho (United States) (US)
- Boston University (US)
- Henry Ford Health (US)
- University of Wisconsin–Madison (US)
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 141
- Issue
- 4
- Pages
- 1468-1475
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC6521865
- OpenAlex
- W2755813430
- Cited by
- 216
- References
- 39
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 26 · 2023: 17 · 2022: 21 · 2021: 30 · 2020: 33 · 2019: 33 · 2018: 29 · 2017: 1
- FWCI
- 19.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Alfred P. Sloan Foundation
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Gilead Sciences
- Teva Pharmaceutical Industries
- Johns Hopkins University (UL1TR001079)
- Regeneron Pharmaceuticals
- Aimmune Therapeutics
- Astellas Pharma
- National Institutes of Health (n01ai25482-15-0-1, HHSN272200900052C, n01ai25496-9-0-0, HHSN272201000052I, UL1TR001079, NO1-AI-25482, UL1TR000040, AI089473, NO1-AI-25496, RR-00052)
- Genentech
- Novartis Pharma
- National Heart, Lung, and Blood Institute (NO1-AI-25482)
- National Institute of Allergy and Infectious Diseases (HHSN272201000052I, NO1-AI-25482, N01 AI025482, N01 AI025496, RR00052, UM1AI114271, AI089473, M01RR00533, UM2AI117870, HHSN272200900052C, NO1-AI-25496, M01RR00071)
- National Center for Research Resources (NO1-AI-25482, M01-RR-00533, NO1-AI-25496, UL1RR024156, RR 000 52, M01RR000052, M01RR000071, M01RR000533, M01-RR-00071, UL1RR025771, UL1RR024992)
- National Center for Advancing Translational Sciences
- Janssen Pharmaceuticals
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- childhood asthma, early life exposure, house dust allergens, cockroach allergens, pet allergens, indoor bacteria, prenatal tobacco exposure, cotinine, maternal stress, maternal depression, inner-city children, asthma risk factors
- MeSH terms
- Adolescent, Allergens, Animals, Asthma, Cats, Child, Cockroaches, Dust, Environmental Exposure, Female, Humans, Male, Mites, Pregnancy, Risk Factors, Social Environment, Urban Population, Cohort Studies, Air Pollution, Indoor, Mice
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