Cited by 36Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsCerebrovascular and genetic disorders

Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI‐Tuscany Study

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Salvadori, Emilia, Poggesi, Anna, Valenti, Raffaella, Pracucci, Giovanni, Pescini, Francesca, Pasi, Marco, Nannucci, Serena, Marini, Sandro +15 more·2016·Alzheimer's & Dementia

Abstract

Introduction: Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile. Methods: In a sample of cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according to different operationalization of Winblad criteria and compared the neuroimaging features of single versus multidomain MCI. We applied three MCI diagnostic scenarios in which the cutoffs for objective impairment and the number of considered neuropsychological tests varied. Results: Passing from a liberal to more conservative diagnostic scenarios, of 153 patients, 5% were no longer classified as MCI, amnestic multidomain frequency decreased, and nonamnestic single domain increased. Considering neuroimaging features, severe medial temporal lobe atrophy was more frequent in multidomain compared with single domain. Discussion: Operationalizing MCI criteria changes the relative frequency of MCI subtypes. Nonamnestic single domain MCI may be a previously nonrecognized type of MCI associated with SVD.

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Authors
Salvadori, E., Poggesi, A., Valenti, R., Pracucci, G., Pescini, F., Pasi, M., Nannucci, S., Marini, S., Del Bene, A., Ciolli, L., Ginestroni, A., Diciotti, S., Orlandi, G., Di Donato, I., De Stefano, N., Cosottini, M., Chiti, A., Federico, A., Dotti, M. T., Bonuccelli, U., Inzitari, D., Pantoni, L., & VMCI‐Tuscany Study Group
Affiliations
  • University of Florence (IT)
  • Azienda Ospedaliero-Universitaria Careggi (IT)
  • NEUROFARBA Department, Neuroscience Section University of Florence Florence Italy
  • University of Bologna (IT)
  • University of Pisa (IT)
  • Department of Medicine, Surgery and Neurosciences University of Siena Siena Italy
  • University of Siena (IT)
Corresponding author
Pantoni, Leonardo
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2015-06-13
Volume
12
Issue
4
Pages
407-418
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W1032188749
Cited by
36
References
39
Citations by year
2024: 1 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 3 · 2019: 4 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 2
FWCI
4.33
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, other-oa)
  • Florence Research (University of Florence) (submittedVersion)
  • Use Siena air (University of Siena) (submittedVersion, other-oa)
Funders
Tuscany region
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
Keywords
mild cognitive impairment, cerebral small vessel disease
MeSH terms
Aged, Atrophy, Cerebrovascular Disorders, Female, Humans, Italy, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Prospective Studies, Temporal Lobe, Disease Progression, Cognitive Dysfunction, Prodromal Symptoms, White Matter

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