Predictive Accuracy of MCI Subtypes for Alzheimer’s Disease and Vascular Dementia in Subjects with Mild Cognitive Impairment: A 2-Year Follow-Up Study
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Aim: The aim of this study was to investigate the prognostic accuracy of different subtypes of mild cognitive impairment (MCI): amnestic MCI, multiple domain MCI, and single non-memory domain MCI, for the development of Alzheimer’s dementia (AD) and vascular dementia (VaD). Patients: Nondemented patients from a memory clinic cohort (n = 118), and a stroke cohort (n = 80, older than 55 years and with a cognitive impairment). Results: ‘Multiple domain MCI’ had the highest sensitivity for both AD (80.8%) and VaD (100%), and ‘amnestic MCI’ had the highest specificity (85.9% for AD, 100% for VaD). The positive predictive value was low for all subtypes (0.0–32.7%), whereas the negative predictive value was high (72.8–100%). Discussion: The subtype ‘multiple domain MCI’ has high sensitivity in identifying people at risk for developing AD or VaD. The predictive accuracy of the MCI subtypes was similar for both AD and VaD.
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MCI reflects a preclinical stage of Alzheimer's disease and other types of dementia in 50 to 60% of MCI subjects.
“MCI reflects a preclinical stage of AD and other types of dementia in 50 to 60% of the MCI subjects”
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- Authors
- Rasquin, S. M. C., Lodder, J., Visser, P. J., Lousberg, R., & Verhey, F. R. J.
- Affiliations
- Maastricht University Medical Centre (NL)
- Neurology, Inc (US)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2005
- Volume
- 19
- Issue
- 2-3
- Pages
- 113-119
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2091159443
- Cited by
- 187
- References
- 2
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 15 · 2017: 6 · 2016: 9 · 2015: 9 · 2014: 7 · 2013: 11 · 2012: 14
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- mild cognitive impairment, MCI subtypes, amnestic MCI, Alzheimer's disease, vascular dementia, dementia prediction, prognostic accuracy, sensitivity and specificity, stroke patients
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Amnesia, Cognition Disorders, Female, Humans, Longitudinal Studies, Male, Memory, Short-Term, Mental Status Schedule, Middle Aged, Neuropsychological Tests, Psychometrics, Retention, Psychology, Risk, Verbal Learning, Dementia, Vascular, Dementia, Multi-Infarct, Reproducibility of Results, Cohort Studies, Disease Progression
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