Age of onset of hypertension and risk of dementia in the oldest‐old: The 90+ Study
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Introduction: We investigated the association between age of onset of hypertension and dementia risk in an oldest‐old cohort. Methods: Participants are from The 90+ Study, a population‐based longitudinal study of people aged 90+ who are survivors from the Leisure World Cohort Study. We estimated hypertension onset age using self‐reported information from The 90+ Study and Leisure World Cohort Study, collected about 20 years earlier. A total of 559 participants without dementia were followed every 6 months for up to 10 years. Results: A total of 224 participants developed dementia during follow‐up (mean = 2.8 years). Compared with those without hypertension, participants whose hypertension onset age was 80 to 89 years had a lower dementia risk (hazard ratio = 0.58, P = .04) and participants with an onset age of 90+ years had the lowest risk (hazard ratio = 0.37, P = .004). Discussion: Developing hypertension at older ages may protect against dementia. Understanding the mechanisms for this lower risk is important for determining ways to prevent dementia in the very elderly.
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Late-life obesity and hypertension onset after age 80 are associated with decreased risk of dementia.
“In contrast, late-life obesity 114 and hypertension onset after age 80 115 are associated with decreased risk of dementia.”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [115]
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- Authors
- Corrada, M. M., Hayden, K. M., Paganini-Hill, A., Bullain, S. S., DeMoss, J., Aguirre, C., Brookmeyer, R., & Kawas, C. H.
- Affiliations
- University of California, Irvine (US)
- Wake Forest University Health Sciences (US)
- Department of Neurology University of California Irvine Irvine CA USA
- University of California, Los Angeles (US)
- Corresponding author
- Corrada, María M.
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2017-01-16
- Volume
- 13
- Issue
- 2
- Pages
- 103-110
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC5318224
- OpenAlex
- W2115381884
- Cited by
- 176
- References
- 44
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 12 · 2023: 17 · 2022: 22 · 2021: 24 · 2020: 20 · 2019: 27 · 2018: 17 · 2017: 7 · 2016: 3 · 2015: 3
- FWCI
- 15.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (R01AG21055, R01AG042444, R01CA32197)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- hypertension, age of onset
- MeSH terms
- Mental Status and Dementia Tests, Aged, 80 and over, Antihypertensive Agents, Dementia, Female, Follow-Up Studies, Humans, Hypertension, Longitudinal Studies, Male, Surveys and Questionnaires, Risk Factors, Severity of Illness Index, Proportional Hazards Models, Age of Onset, Self Report
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