Cited by 189Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

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Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample

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Brenowitz, Willa D., Hubbard, Rebecca A., Keene, C. Dirk, Hawes, Stephen E., Longstreth, W.T., Woltjer, Randy L., Kukull, Walter A.·2017·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2016.09.015PMC PMC5438283

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Abstract

Introduction: Whether co‐occurring neuropathologies interact or independently affect clinical disease progression is uncertain. We estimated rates of clinical progression and tested whether associations between clinical progression and Alzheimer's disease neuropathology (ADNP) were modified by co‐occurring Lewy body disease (LBD) or vascular brain injury (VBI). Methods: Linear mixed effects models evaluated longitudinal trends in the Clinical Dementia Rating Scale Sum of Boxes on 2046 autopsied participants seen at a U.S. Alzheimer's Disease Center. Results: Annual clinical progression was slightly faster for ADNP + LBD compared with ADNP only (P = .06) and slightly slower for ADNP + VBI (P = .003). Differences in progression were less than expected if each neuropathology independently contributed to progression; ADNP interacted with LBD (P = .002) and VBI (P = .003). In secondary models, the effect of additional pathologies on clinical progression was greater in those with intermediate compared with high levels of ADNP. Discussion: The impact of co‐occurring pathologies on progression may depend on severity of ADNP.

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Authors: Brenowitz, W. D., Hubbard, R. A., Keene, C. D., Hawes, S. E., Longstreth, W. T., Woltjer, R. L., & Kukull, W. A.
Affiliations: University of Washington (US)
University of Pennsylvania (US)
Oregon Health & Science University (US)
Corresponding author: Brenowitz, Willa D.
ORCID: Brenowitz, Willa D.
Hubbard, Rebecca A.
Keene, C. Dirk
Hawes, Stephen E.
Woltjer, Randy L.
Kukull, Walter A.
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2016-11-18
Volume: 13
Issue: 6
Pages: 654-662
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2016.09.015
PMC: PMC5438283
OpenAlex: W2556839390
Cited by: 188
References: 58
Citations by year: 2026: 20 · 2025: 21 · 2024: 22 · 2023: 51 · 2022: 19 · 2021: 15 · 2020: 14 · 2019: 11 · 2018: 8 · 2017: 5 · 2016: 1
FWCI: 7.41
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P30 AG019610, P30 AG013846, P50 AG008702, P50 AG025688, P50 AG047266, P30 AG010133, P50 AG005146, P50 AG005134, P50 AG016574, P50 AG005138, P30 AG008051, P30 AG013854, P30 AG008017, P30 AG010161, P50 AG047366, P30 AG010129, P50 AG016573, P50 AG016570, P50 AG005131, P50 AG023501, P30 AG035982, P30 AG028383, P30 AG010124, P50 AG005133, P50 AG005142, P30 AG012300, P50 AG005136, P50 AG033514, P50 AG005681, P50 AG047270)
National Institutes of Health
National Association for Colitis and Crohn's Disease
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: Alzheimer's disease pathology, Lewy body disease
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Autopsy, Brain, Cerebrovascular Disorders, Female, Humans, Longitudinal Studies, Male, Prospective Studies, Multivariate Analysis, Linear Models, Disease Progression, Lewy Body Disease

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