Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale
Abstract
Introduction: Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir. Methods: Florbetapir and Pittsburgh compound B scans were acquired for 46 mixed clinical presentation subjects within 18 ± 20 days. Florbetapir and Pittsburgh compound B cortical standardized uptake value ratio (SUVr) values were well correlated for both standard Centiloid (R 2 = 0.894) and Avid (R 2 = 0.901) volume of interests (VOIs). The methods of Klunk et al. were applied to establish a conversion first from florbetapir SUVr values obtained using standard Centiloid VOIs to Centiloids and then from Avid VOIs (Joshi et al.) to Centiloids. Results: The equation for conversion of florbetapir SUVr from Avid VOIs to the Centiloid scale was as follows: Florbetapir Centiloids = 183 × SUVr Avid − 177. The threshold that discriminated neuropathologically verified none or sparse versus moderate to frequent plaques in autopsy‐confirmed data is 24.1 Centiloids. Discussion: These findings may allow improved tracer‐independent amyloid quantitation.
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Amyloid PET ligands display 85%-98% sensitivity and 87%-100% specificity for Aβ plaques against postmortem CERAD or NIA-AA standards.
“18 F-flutemetamol, 18 F-florbetaben and 18 F-florbetapir tracers display 85%-98% sensitivity and 87%-100% specificity for Aβ plaques when using the postmortem truth standards of the Consortium to Establish a Registry for AD (CERAD) or the National Institute on Aging-Alzheimer's Association 85,[136][137][138] .”
From The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics (2022) · cites this paper as [137]
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Self-citation
- Authors
- Navitsky, M., Joshi, A. D., Kennedy, I., Klunk, W. E., Rowe, C. C., Wong, D. F., Pontecorvo, M. J., Mintun, M. A., & Devous, M. D.
- Affiliations
- Avid Radiopharmaceuticals (United States) (US)
- University of Pittsburgh (US)
- The University of Melbourne (AU)
- Johns Hopkins University (US)
- Corresponding author
- Devous, Michael D.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2018-07-10
- Volume
- 14
- Issue
- 12
- Pages
- 1565-1571
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2849227165
- Cited by
- 229
- References
- 20
- Citations by year
- 2026: 46 · 2025: 52 · 2024: 27 · 2023: 15 · 2022: 30 · 2021: 33 · 2020: 16 · 2019: 8 · 2018: 2
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (AG025204, AG025516, AG005133)
- Johnson and Johnson
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- florbetapir
- MeSH terms
- Adult, Aged, Amyloid, Aniline Compounds, Brain, Ethylene Glycols, Female, Humans, Male, Thiazoles, Cohort Studies, Radiopharmaceuticals, Positron-Emission Tomography
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