Cited by 229Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedical Imaging Techniques and Applications

Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale

Navitsky, Michael, Joshi, Abhinay D., Kennedy, Ian, Klunk, William E., Rowe, Christopher C., Wong, Dean F., Pontecorvo, Michael J., Mintun, Mark A. +1 more·2018·Alzheimer's & Dementia

Abstract

Introduction: Klunk et al. recently proposed a means of standardizing quantitation of amyloid burden from positron emission tomography scans to a common Centiloid scale, and we have applied that method to florbetapir. Methods: Florbetapir and Pittsburgh compound B scans were acquired for 46 mixed clinical presentation subjects within 18 ± 20 days. Florbetapir and Pittsburgh compound B cortical standardized uptake value ratio (SUVr) values were well correlated for both standard Centiloid (R 2 = 0.894) and Avid (R 2 = 0.901) volume of interests (VOIs). The methods of Klunk et al. were applied to establish a conversion first from florbetapir SUVr values obtained using standard Centiloid VOIs to Centiloids and then from Avid VOIs (Joshi et al.) to Centiloids. Results: The equation for conversion of florbetapir SUVr from Avid VOIs to the Centiloid scale was as follows: Florbetapir Centiloids = 183 × SUVr Avid − 177. The threshold that discriminated neuropathologically verified none or sparse versus moderate to frequent plaques in autopsy‐confirmed data is 24.1 Centiloids. Discussion: These findings may allow improved tracer‐independent amyloid quantitation.

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Crossref · 10.1016/j.jalz.2018.06.1353

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  • Amyloid PET ligands display 85%-98% sensitivity and 87%-100% specificity for Aβ plaques against postmortem CERAD or NIA-AA standards.

    “18 F-flutemetamol, 18 F-florbetaben and 18 F-florbetapir tracers display 85%-98% sensitivity and 87%-100% specificity for Aβ plaques when using the postmortem truth standards of the Consortium to Establish a Registry for AD (CERAD) or the National Institute on Aging-Alzheimer's Association 85,[136][137][138] .”

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Authors
Navitsky, M., Joshi, A. D., Kennedy, I., Klunk, W. E., Rowe, C. C., Wong, D. F., Pontecorvo, M. J., Mintun, M. A., & Devous, M. D.
Affiliations
  • Avid Radiopharmaceuticals (United States) (US)
  • University of Pittsburgh (US)
  • The University of Melbourne (AU)
  • Johns Hopkins University (US)
Corresponding author
Devous, Michael D.
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2018-07-10
Volume
14
Issue
12
Pages
1565-1571
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W2849227165
Cited by
229
References
20
Citations by year
2026: 46 · 2025: 52 · 2024: 27 · 2023: 15 · 2022: 30 · 2021: 33 · 2020: 16 · 2019: 8 · 2018: 2
FWCI
11.61
Type
journal article
Language
en
Open access
closed
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (AG025204, AG025516, AG005133)
  • Johnson and Johnson
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords
florbetapir
MeSH terms
Adult, Aged, Amyloid, Aniline Compounds, Brain, Ethylene Glycols, Female, Humans, Male, Thiazoles, Cohort Studies, Radiopharmaceuticals, Positron-Emission Tomography

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