Gut hormones and gut microbiota: implications for kidney function and hypertension
Open accessAbstract
Increased blood pressure (BP) and chronic kidney disease are two leading risk factors for cardiovascular disease. Increased sodium intake is one of the most important risk factors for development of hypertension. Recent data have shown that gut influences kidney function and BP by variety of mechanisms. Various hormones and peptides secreted from gut such as gastrin, glucocorticoids, Glucagon-like peptide-1 impact on kidney function and BP especially influencing sodium absorption from gut. These findings stimulate scientist to find new therapeutic options such as tenapanor for treatment of hypertension by blocking sodium absorption from gut. The gastrointestinal tract is also occupied by a huge community of microbes (microbiome) that under normal condition has a symbiotic relationship with the host. Alterations in the structure and function of the gut microbiota have been shown to play a key role in the pathogenesis and complications of numerous diseases including hypertension. Based on these data, in this review, we provide a summary of the available data on the role of gut and gut microbiota in regulation of BP and kidney function.
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The GLP1 agonist liraglutide and dipeptidyl peptidase 4 inhibitors lower blood pressure in obese animals and in patients with hypertension and type 2 diabetes mellitus.
“The GLP1 agonist liraglutide and dipeptidyl peptidase 4 (DPP4) inhibitors, which attenuate degradation of GLP1, lower BP in obese animals and in patients with hypertension and T2DM108.”
From Obesity, kidney dysfunction and hypertension: mechanistic links (2019) · cites this paper as [108]
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Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913 · see citing works
Sacks, F. M., Svetkey, L. P., Vollmer, W. M., Appel, L. J., Bray, G. A., Harsha, D., Obarzanek, E., Conlin, P. R., Miller, E. R., Simons-Morton, D. G., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200101043440101 · Cited by 5,638 · see citing works
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works
Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,395 · see citing works
Kimura, I., Ozawa, K., Inoue, D., Imamura, T., Kimura, K., Maeda, T., Terasawa, K., Kashihara, D., Hirano, K., Tani, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2852 · Cited by 1,512 · see citing works
Gut Dysbiosis Is Linked to Hypertension
Yang, T., Santisteban, M. M., Rodriguez, V., Li, E., Ahmari, N., Carvajal, J. M., Zadeh, M., Gong, M., Qi, Y., Zubcevic, J., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05315 · Cited by 1,478 · see citing works
Tang, W. H. W., Wang, Z., Kennedy, D. J., Wu, Y., Buffa, J. A., Agatisa-Boyle, B., Li, X. S., Levison, B. S., & Hazen, S. L. (2015) · Circulation Research · doi:10.1161/circresaha.116.305360 · Cited by 1,223 · see citing works
Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191 · see citing works
Kimura, I., Inoue, D., Maeda, T., Hara, T., Ichimura, A., Miyauchi, S., Kobayashi, M., Hirasawa, A., & Tsujimoto, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016088108 · Cited by 1,106 · see citing works
Gut microbiome, obesity, and metabolic dysfunction
Tilg, H., & Kaser, A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58109 · Cited by 860 · see citing works
Furness, J. B., Rivera, L. R., Cho, H., Bravo, D. M., & Callaghan, B. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.180 · Cited by 549 · see citing works
The pathophysiology of hypertension in patients with obesity
DeMarco, V. G., Aroor, A. R., & Sowers, J. R. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.44 · Cited by 545 · see citing works
Cardiovascular Biology of the Incretin System
Ussher, J. R., & Drucker, D. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1052 · Cited by 527 · see citing works
Glucagon-Like Peptide 1 Induces Natriuresis in Healthy Subjects and in Insulin-Resistant Obese Men
Gutzwiller, J.-P., Tschopp, S., Bock, A., Zehnder, C. E., Huber, A. R., Kreyenbuehl, M., Gutmann, H., Drewe, J., Henzen, C., Goeke, B., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031403 · Cited by 442 · see citing works
Evidence for a link between gut microbiota and hypertension in the Dahl rat
Mell, B., Jala, V. R., Mathew, A. V., Byun, J., Waghulde, H., Zhang, Y., Haribabu, B., Vijay-Kumar, M., Pennathur, S., & Joe, B. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00136.2014 · Cited by 400 · see citing works
A novel SCFA receptor, the microbiota, and blood pressure regulation
Pluznick, J. (2014) · Gut Microbes · doi:10.4161/gmic.27492 · Cited by 374 · see citing works
Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats
Yu, M., Moreno, C., Hoagland, K. M., Dahly, A., Ditter, K., Mistry, M., & Roman, R. (2003) · Journal of Hypertension · doi:10.1097/00004872-200306000-00012 · Cited by 292 · see citing works
Crajoinas, R. O., Oricchio, F. T., Pessoa, T. D., Pacheco, B. P. M., Lessa, L. M. A., Malnic, G., & Girardi, A. C. C. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00729.2010 · Cited by 278 · see citing works
Heerspink, H. J. L., Holtkamp, F. A., Parving, H., Navis, G. J., Lewis, J. B., Ritz, E., de Graeff, P. A., & de Zeeuw, D. (2012) · Kidney International · doi:10.1038/ki.2012.74 · Cited by 256 · see citing works
Salt sensitivity. Definition, conception, methodology, and long-term issues.
Sullivan, J. M. (1991) · Hypertension · doi:10.1161/01.hyp.17.1_suppl.i61 · Cited by 215 · see citing works
Gut microbiota in hypertension
José, P. A., & Raj, D. S. (2015) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000149 · Cited by 187 · see citing works
Kröller‐Schön, S., Knorr, M., Hausding, M., Oelze, M. W., Schuff, A., Schell, R., Sudowe, S., Scholz, A., Daub, S., Karbach, S. H., et al. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs246 · Cited by 174 · see citing works
Carraro‐Lacroix, L. R., Malnic, G., & Girardi, A. C. C. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00082.2009 · Cited by 163 · see citing works
From microbe to man: the role of microbial short chain fatty acid metabolites in host cell biology
Natarajan, N., & Pluznick, J. L. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2014 · Cited by 163 · see citing works
Spencer, A. G., Labonté, E. D., Rosenbaum, D. P., Plato, C. F., Carreras, C. W., Leadbetter, M. R., Kozuka, K., Kohler, J. N., Koo-McCoy, S., He, L., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007790 · Cited by 161 · see citing works
Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model.
Hirata, K., Kume, S., Araki, S., Sakaguchi, M., Chin-Kanasaki, M., Isshiki, K., Sugimoto, T., Nishiyama, A., Koya, D., Haneda, M., et al. (2009) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2009.01.003 · Cited by 160 · see citing works
Intestinal NaCl transport in NHE2 and NHE3 knockout mice
Gawenis, L. R., Stien, X., Shull, G. E., Schultheis, P. J., Woo, A. L., Walker, N. M., & Clarke, L. L. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00297.2001 · Cited by 153 · see citing works
Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells
Schlatter, P., Beglinger, C., Drewe, J., & Gutmann, H. (2007) · Regulatory Peptides · doi:10.1016/j.regpep.2006.12.016 · Cited by 149 · see citing works
Localisation and mechanism of renal retention of radiolabelled somatostatin analogues
Melis, M. L., Krenning, E. P., Bernard, B. F., Barone, R., Visser, T. J., & de Jong, M. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1793-0 · Cited by 136 · see citing works
Chelikani, P. K., Haver, A. C., & Reidelberger, R. D. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00870.2004 · Cited by 128 · see citing works
Labonté, E. D., Carreras, C. W., Leadbetter, M. R., Kozuka, K., Kohler, J. N., Koo-McCoy, S., He, L., Dy, E. E., Black, D., Zhong, Z., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014030317 · Cited by 111 · see citing works
The Role of Microbiota on the Gut Immunology
Min, Y. W., & Rhee, P. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.03.009 · Cited by 111 · see citing works
Aroor, A. R., Sowers, J. R., Bender, S. B., Nistala, R., Garro, M., Mugerfeld, I., Hayden, M. R., Johnson, M. S., Salam, M., Whaley‐Connell, A. T., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1096 · Cited by 103 · see citing works
Michell, A. R., Debnam, E. S., & Unwin, R. J. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.69.040705.141330 · Cited by 95 · see citing works
Mechanisms of the Regulation of the Intestinal Na+/H+ Exchanger NHE3
He, P., & Yun, C. C. (2009) · BioMed Research International · doi:10.1155/2010/238080 · Cited by 92 · see citing works
Linz, D., WIRTH, K. J., Linz, W., Heuer, H., Frick, W., Hofmeister, A., Heinelt, U., Arndt, P., Schwahn, U., Böhm, M., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.201590 · Cited by 87 · see citing works
EFFECTS OF CHRONIC EXCESS SALT INGESTION
Knudsen, K. D., Dahl, L. K., Thompson, K. H., Iwai, J., Heine, M., & Leitl, G. (1970) · The Journal of Experimental Medicine · doi:10.1084/jem.132.5.976 · Cited by 82 · see citing works
Non-Systemic Drugs: A Critical Review
Charmot, D. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799504858 · Cited by 81 · see citing works
Target organ cross talk in cardiorenal syndrome: animal models
Bongartz, L. G., Braam, B. G., Gaillard, S., Cramer, M. J., Goldschmeding, R., Verhaar, M. C., Doevendans, P. A., & Joles, J. A. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00392.2012 · Cited by 80 · see citing works
Cho, J. H., Musch, M. W., Bookstein, C., McSwine, R. L., Rabenau, K. E., & Chang, E. B. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.3.c586 · Cited by 79 · see citing works
Dietary Salt Intake, Salt Sensitivity, and Cardiovascular Health
Sanders, P. W. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.120303 · Cited by 73 · see citing works
Frindt, G., & Palmer, L. G. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00480.2011 · Cited by 51 · see citing works
Gray, C., Al‐Dujaili, E. A. S., Sparrow, A. J., Gardiner, S. M., Craigon, J., Welham, S. J. M., & Gardner, D. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072682 · Cited by 38 · see citing works
Liu, T., & José, P. A. (2012) · Endocrinology · doi:10.1210/en.2012-1813 · Cited by 34 · see citing works
The importance of the gastrorenal axis in the control of body sodium homeostasis
José, P. A., Yang, Z., Zeng, C., & Felder, R. A. (2016) · Experimental Physiology · doi:10.1113/ep085286 · Cited by 28 · see citing works
Urinary Sodium Excretion and Ambulatory Blood Pressure Findings in Patients With Hypertension
Afşar, B., Elsürer, R., Kırkpantur, A., & Kanbay, M. (2015) · Journal of Clinical Hypertension · doi:10.1111/jch.12464 · Cited by 24 · see citing works
Self-citationPharmacologic inhibition of intestinal sodium uptake
Spencer, A. G., & Greasley, P. J. (2015) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000154 · Cited by 24 · see citing works
Effect of excessive salt intake: Role of plasma sodium
Reuter, S., Büssemaker, E., Hausberg, M., Pavenstädt, H., & Hillebrand, U. (2009) · Current Hypertension Reports · doi:10.1007/s11906-009-0018-5 · Cited by 17 · see citing works
Can we improve the treatment of congestion in heart failure?
Metra, M., Bugatti, S., Bettari, L., Carubelli, V., Danesi, R., Lazzarini, V., Lombardi, C., & Cas, L. D. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.557069 · Cited by 15 · see citing works
Effects of pentagastrin on intestinal absorption and blood flow in the anaesthetized dog.
Mailman, D. S. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013444 · Cited by 11 · see citing works
Evidence that peroral calcium does not activate the gastrin-ECL-cell axis in the rat
Surve, V. V., & Håkanson, R. (1998) · Regulatory Peptides · doi:10.1016/s0167-0115(98)00002-0 · Cited by 6 · see citing works
The importance of intake: a gut feeling.
Gerritsen, K. G. F., Boer, W. H., & Joles, J. A. (2015) · PubMed · doi:10.3978/j.issn.2305-5839.2015.03.21 · Cited by 6 · see citing works
Gildea, J. J., Xu, P., Zhang, C., Wang, D. B., Tran, H. T., José, P. A., & Felder, R. A. (2015) · Hypertension · doi:10.1161/hyp.66.suppl_1.087 · Cited by 4 · see citing works
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Jia, G., & Sowers, J. R. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.17981 · Cited by 459 · see citing works
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Chen, Y., Chen, D., Chen, L., Liu, J., Vaziri, N. D., Guo, Y. P., & Zhao, Y. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-018-1756-4 · Cited by 430 · see citing works
Self-citationBeyond gut feelings: how the gut microbiota regulates blood pressure
Marques, F. Z., Mackay, C. R., & Kaye, D. M. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.120 · Cited by 397 · see citing works
Gut microbiota and cardiovascular disease: opportunities and challenges
Kazemian, N., Mahmoudi, M., Halperin, F. A., Wu, J. C., & Pakpour, S. (2020) · Microbiome · doi:10.1186/s40168-020-00821-0 · Cited by 392 · see citing works
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Hall, J. E., Mouton, A. J., da Silva, A. A., Omoto, A. C. M., Wang, Z., Li, X., & do Carmo, J. M. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa336 · Cited by 279 · see citing works
The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation
Rahman, M. M., Islam, F., Harun-Or-Rashid, M., Mamun, A. A., Rahaman, M. S., Islam, M. M., Meem, A. F. K., Sutradhar, P. R., Mitra, S., Mimi, A. A., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.903570 · Cited by 267 · see citing works
Intestinal microbiome and fitness in kidney disease
Meijers, B. K. I., Evenepoel, P., & Anders, H. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0172-1 · Cited by 223 · see citing works
Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis
Li, Z., Wu, Z., Yan, J., Liu, H., Liu, Q., Deng, Y., Ou, C., & Chen, M. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0091-y · Cited by 218 · see citing works
The impact of gut microbiota on kidney function and pathogenesis
Mahmoodpoor, F., Saadat, Y. R., Barzegari, A., Ardalan, M., & Vahed, S. Z. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.066 · Cited by 171 · see citing works
Hypertension as a Metabolic Disorder and the Novel Role of the Gut
Tanaka, M., & Itoh, H. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0964-5 · Cited by 118 · see citing works
Diabetic Vasculopathy: Molecular Mechanisms and Clinical Insights
Jia, G., Bai, H., Mather, B., Hill, M. A., Jia, G., & Sowers, J. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020804 · Cited by 119 · see citing works
Onal, E. M., Afşar, B., Covic, A. C., Vaziri, N. D., & Kanbay, M. (2018) · Hypertension Research · doi:10.1038/s41440-018-0144-z · Cited by 106 · see citing works
Self-citationThe gut microbiota and its relationship with chronic kidney disease
Plata, C., Cruz, C., Cervantes, L. G., & Ramírez, V. (2019) · International Urology and Nephrology · doi:10.1007/s11255-019-02291-2 · Cited by 100 · see citing works
Sodium Homeostasis, a Balance Necessary for Life
Bernal, A., Zafra, M. A., Simón, M. J., & Mahía, J. (2023) · Nutrients · doi:10.3390/nu15020395 · Cited by 101 · see citing works
Amino Acid Metabolism in the Kidneys: Nutritional and Physiological Significance
Li, X., Zheng, S., & Wu, G. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-45328-2_5 · Cited by 93 · see citing works
Gut microbiota, hypertension and chronic kidney disease: Recent advances
Sircana, A., Michieli, F. D., Parente, R., Framarin, L., Leone, N., Berrutti, M., Paschetta, E., Bongiovanni, D., & Musso, G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.013 · Cited by 86 · see citing works
Gut microbiota and hypertension: From pathogenesis to new therapeutic strategies
Kang, Y., & Cai, Y. (2017) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2017.09.006 · Cited by 84 · see citing works
Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease
Jazani, N. H., Savoj, J., Lustgarten, M. S., Lau, W. L., & Vaziri, N. D. (2019) · Diseases · doi:10.3390/diseases7010021 · Cited by 82 · see citing works
Self-citationThe Role of the Gut Microbiota in Coronary Heart Disease
Liu, H., Zhuang, J., Tang, P., Li, J., Xiong, X., & Deng, H. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00892-2 · Cited by 74 · see citing works
Keto microbiota: A powerful contributor to host disease recovery
Cabrera-Mulero, A., Tinahones, A., Bandera-Merchán, B., Moreno‐Indias, I., Macías‐González, M., & Tinahones, F. J. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09518-8 · Cited by 70 · see citing works
Bariatric Surgery and Hypertension
Owen, J., Yazdi, F., & Reisin, E. (2017) · American Journal of Hypertension · doi:10.1093/ajh/hpx112 · Cited by 67 · see citing works
Gut microbiota in kidney disease and hypertension
Antza, C., Stabouli, S., & Kotsis, V. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.02.028 · Cited by 61 · see citing works
Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases
Mutalub, Y. B., Abdulwahab, M., Mohammed, A., Yahkub, A. M., Al-Mhanna, S. B., Yusof, W., Tang, S. P., Rasool, A. H. G., & Mokhtar, S. S. (2022) · Foods · doi:10.3390/foods11172575 · Cited by 60 · see citing works
Climent, E., Goday, A., Pedro‐Botet, J., Solà, I., Oliveras, A., Ramón, J. M., Roux, J. A. F., Checa, M. Á., & Benaiges, D. (2019) · Journal of Hypertension · doi:10.1097/hjh.0000000000002255 · Cited by 55 · see citing works
Lakshmanan, A. P., Murugesan, S., Khodor, S. A., & Terranegra, A. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03631-0 · Cited by 58 · see citing works
Canale, M. P., Noce, A., Lauro, M. D., Marrone, G., Cantelmo, M., Cardillo, C., Federici, M., Daniele, N. D., & Tesauro, M. (2021) · Nutrients · doi:10.3390/nu13041162 · Cited by 51 · see citing works
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Dietary and commercialized fructose: Sweet or sour?
Yerlikaya, A., Dağel, T., King, C., Kuwabara, M., Lanaspa, M. A., Andrés-Hernando, A., Covic, A. C., Manitius, J., Sag, A. A., & Kanbay, M. (2017) · International Urology and Nephrology · doi:10.1007/s11255-017-1544-8 · Cited by 32 · see citing works
Self-citationZhu, J., Fu, Y., Olovo, C. V., Xu, J., Wu, Q., Wei, W., Jiang, K., & Zheng, X. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1535356 · Cited by 31 · see citing works
Lu, J., Jin, X., Yang, S., Li, Y., Wang, X., & Wu, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1034537 · Cited by 32 · see citing works
Hu, Q., Wu, K., Pan, W., Zeng, Y. J., Hu, K., Chen, D., Huang, X., & Zhang, Q. (2020) · Journal of International Medical Research · doi:10.1177/0300060520926033 · Cited by 29 · see citing works
Hu, S., Wang, J., Wang, J., Li, S., Jiang, W., & Liu, Y. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.01.031 · Cited by 26 · see citing works
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Hypertension Opens the Flood Gates to the Gut Microbiota
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Hypertension and cellular senescence
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Circulating GLP-1 Levels as a Potential Indicator of Metabolic Syndrome Risk in Adult Women
Seon, M. J., Hwang, S. Y., Son, Y., Song, J., & Kim, O. Y. (2021) · Nutrients · doi:10.3390/nu13030865 · Cited by 21 · see citing works
Linz, B. M., Saljic, A., Hohl, M., Gawalko, M. M., Jespersen, T., Sanders, P., Böhm, M., & Linz, D. (2020) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2020.100591 · Cited by 20 · see citing works
Bariatric Surgery Improves Renal Function: a Large Inner-City Population Outcome Study
Saeed, K., Ahmed, L., Suman, P., Gray, S. F.-M., Khan, K., DePaz, H. A., Persaud, A., Fox, B. P., Alothman, S., & Saeed, S. (2020) · Obesity Surgery · doi:10.1007/s11695-020-04909-2 · Cited by 16 · see citing works
Xu, Z., Meng, Q., Ge, X., Zhuang, R., Liu, J., Liang, X., Fan, H., Yu, P., Zheng, L., & Zhou, X. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104482 · Cited by 14 · see citing works
Nafady, M. H., Sayed, Z. S., Abdelkawy, D. A., Shebl, M. E., Elsayed, R. A., Ashraf, G. M., Perveen, A., Attia, M. S., & Bahbah, E. I. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220419101205 · Cited by 13 · see citing works
Ertuğlu, L. A., Demiray, A., Afşar, B., Ortíz, A., & Kanbay, M. (2022) · Current Nutrition Reports · doi:10.1007/s13668-022-00415-2 · Cited by 11 · see citing works
Self-citationCurrent epigenetic aspects the clinical kidney researcher should embrace.
Witasp, A., Craenenbroeck, A. V. V., Shiels, P., Ekström, T., Stenvinkel, P., & Nordfors, L. (2017) · Clinical science · doi:10.1042/cs20160596 · Cited by 11 · see citing works
COLONIC MICROBIOTA AND CHRONIC KIDNEY DISEASE. MESSAGE ONE
Lukichev, B. G., Rumyantsev, A. S., & Акименко, В. Б. (2018) · Nephrology (Saint-Petersburg) · doi:10.24884/1561-6274-2018-22-4-57-73 · Cited by 11 · see citing works
Chen, Z., Yang, B., Wang, Z., Rong, X., Zhu, Q., & Guo, J. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.854849 · Cited by 11 · see citing works
Gastrointestinal Tract: a Promising Target for the Management of Hypertension
Xiong, S., Li, Q., Liu, D., & Zhu, Z. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0726-1 · Cited by 10 · see citing works
Xu, X., Chen, J., Lv, H., Xi, Y., Ying, A., & Hu, X. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153929 · Cited by 10 · see citing works
Liu, C., Wen, C., Olatunji, O. J., Suttikhana, I., & Ashaolu, T. J. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106592 · Cited by 8 · see citing works
Yang, Z., Ni, J., Sun, X., Cui, Q., Zhang, X., Zhang, M., Zhu, X., Wu, Z., Tang, C., Zhu, J., et al. (2024) · Microbiology and Immunology · doi:10.1111/1348-0421.13130 · Cited by 7 · see citing works
Probiotic use in the management of hypertension: A new era of therapeutic management
Nivsarkar, M., Borse, S., Singh, D., Upadhyay, D., & Sharma, V. (2018) · Indian Journal of Health Sciences and Biomedical Research (KLEU) · doi:10.4103/kleuhsj.kleuhsj_3_18 · Cited by 7 · see citing works
Morvaridzadeh, M., Alami, M., Berrougui, H., Boumezough, K., Sidibé, H., Salih, I., Sadki, K., & Khalil, A. (2025) · Nutrients · doi:10.3390/nu17233784 · Cited by 6 · see citing works
Chrysant, S. G. (2024) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2024.2364031 · Cited by 5 · see citing works
Abolhassani, A., Moghadasian, M. H., Sedaghatnezhad, N., & Jafarnejad, S. (2025) · Heart and Mind · doi:10.4103/hm.hm-d-24-00161 · Cited by 4 · see citing works
Ibeabuchi, C. G., Patrick-Iwuanyanwu, K. C., Oyeike, E. N., & Akaninwor, J. O. (2023) · IPS Journal of Nutrition and Food Science · doi:10.54117/ijnfs.v2i2.27 · Cited by 4 · see citing works
Biomedical Treatment Nanomotors Based on the Intestinal Axis: Current Challenges
Zhang, L., Du, Y., Wang, W., Gao, R., Dong, Y., Wang, Q., & Tong, F. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00433 · Cited by 2 · see citing works
Xu, C., Li, Z., Zeng, Y., Luo, H., & Xia, X. (2025) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2025.2584566 · Cited by 2 · see citing works
Renal experiences of bariatric surgery in patients with type 2 diabetes mellitus
Larina, I. M., Severina, A. S., Шамхалова, М. Ш., & Shestakova, M. V. (2018) · Terapevticheskii arkhiv · doi:10.26442/terarkh201890104-108 · Cited by 1 · see citing works
张, 阳. (2024) · Traditional Chinese Medicine · doi:10.12677/tcm.2024.139361 · Cited by 1 · see citing works
Zhang, M., Fan, B., & Yu, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.762959
Human microbiome, obesity and cardiovascular diseases
Piansay‐Soriano, M. E., Soriano, S. K., Pague, B. V., Platero, M. S., Candelario-Plata, M. A., & Calunsag, M. K. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15435-5.00008-6
ETIOPATHOGENESIS AND MANAGEMENT OF VATARAKTHA (GOUT) W.S.R. TO GUT MICROBIOME.
Shreya, R., Hirulal, M., & Akki, H. S. (2025) · International Ayurvedic Medical Journal · doi:10.46607/iamj0613102025
- Authors
- Afsar, B., Vaziri, N. D., Aslan, G., Tarim, K., & Kanbay, M.
- Affiliations
- University of California, Irvine (US)
- Koç University (TR)
- Corresponding author
- Kanbay, Mehmet
- Venue
- Journal of the American Society of Hypertension
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 10
- Issue
- 12
- Pages
- 954-961
- ISSN
- 1878-7436 (ISSN-L)
- 1933-1711
- OpenAlex
- W2548100645
- Cited by
- 63
- References
- 53
- Citations by year
- 2025: 6 · 2024: 6 · 2023: 3 · 2022: 10 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 7 · 2017: 10
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Locations
- Journal of the American Society of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- gastrointestinal hormones, gut microbiota, hypertension, renal function, chronic kidney disease, sodium uptake, gastrin, glucocorticoids, glucagon-like peptide-1, tenapanor, blood pressure regulation, sodium intake
- MeSH terms
- Gastrointestinal Microbiome, Blood Pressure, Cardiovascular Diseases, Gastrointestinal Hormones, Humans, Hypertension, Intestinal Absorption, Intestines, Isoquinolines, Sodium, Dietary, Sulfonamides, Renal Insufficiency, Chronic
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