Gut microbiome, obesity, and metabolic dysfunction
Open accessAbstract
The prevalence of obesity and related disorders such as metabolic syndrome has vastly increased throughout the world. Recent insights have generated an entirely new perspective suggesting that our microbiota might be involved in the development of these disorders. Studies have demonstrated that obesity and metabolic syndrome may be associated with profound microbiotal changes, and the induction of a metabolic syndrome phenotype through fecal transplants corroborates the important role of the microbiota in this disease. Dietary composition and caloric intake appear to swiftly regulate intestinal microbial composition and function. As most findings in this field of research are based on mouse studies, the relevance to human biology requires further investigation.
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Abnormal diversity (dysbiosis) in the gut has been proven to be associated with human diseases such as obesity, inflammatory bowel disease, and cancer.
“Abnormal diversity (dysbiosis) in the gut has been proven to be associated with human diseases, such as obesity, inflammatory bowel disease, cancer, etc. 20,21,33,34”
From The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti–Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC (2019) · cites this paper as [33]
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- Authors
- Tilg, H., & Kaser, A.
- Affiliations
- Innsbruck Medical University (AT)
- University of Cambridge (GB)
- Corresponding author
- Tilg, Herbert
- Venue
- Journal of Clinical Investigation
- Published
- 2011-06-01
- Volume
- 121
- Issue
- 6
- Pages
- 2126-2132
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3104783
- OpenAlex
- W2031821244
- Cited by
- 860
- References
- 18
- Citations by year
- 2026: 15 · 2025: 32 · 2024: 39 · 2023: 49 · 2022: 65 · 2021: 90 · 2020: 68 · 2019: 63 · 2018: 65 · 2017: 59 · 2016: 66 · 2015: 59 · 2014: 56 · 2013: 80 · 2012: 38
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan
- National Institute for Health and Care Research
- NIHR Cambridge Biomedical Research Centre
- FP7 Ideas: European Research Council (260961)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut microbiota, obesity, metabolic syndrome, metabolic dysfunction, fecal microbiota transplantation, diet composition, energy intake, host-microbe interactions
- MeSH terms
- Animals, Bacteria, Dietary Carbohydrates, Dietary Fats, Digestion, Disease Models, Animal, Energy Metabolism, Germ-Free Life, Humans, Inflammation, Metabolic Diseases, Mice, Mutant Strains, Obesity, Species Specificity, Bacterial Translocation, Genetic Predisposition to Disease, Gastrointestinal Tract, Mice, Metabolic Networks and Pathways, Metagenome
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