Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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Tumor cell metabolism: cancer's Achilles' heel

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ATP citrate lyase inhibition can suppress tumor cell growth

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Metabolic networks in motion: 13C‐based flux analysis

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Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

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Network Rigidity and Metabolic Engineering in Metabolite Overproduction

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Elementary metabolite units (EMU): A novel framework for modeling isotopic distributions

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Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements

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Gas Chromatography Coupled to Mass Spectrometry (GC–MS) to Study Metabolism in Cultured Cells

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Deuterium Tracing to Interrogate Compartment-Specific NAD(P)H Metabolism in Cultured Mammalian Cells

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Effects of Acute Subdural Hematoma-Induced Brain Injury On Energy Metabolism in Peripheral Blood Mononuclear Cells

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Metabolic Fluxes in Cancer Metabolism

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Estimation of flux ratios without uptake or release data: Application to serine and methionine metabolism

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Computational data mining method for isotopomer analysis in the quantitative assessment of metabolic reprogramming

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Oncogenic metabolic rewiring independent of proliferative control in human mammary epithelial cellsPreprint

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Parallel isotope differential modeling for instationary 13C fluxomics at the genome scale

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Hot isopropanol quenching procedure for automated microtiter plate scale 13C-labeling experiments

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Mathematical Modeling of Isotope Labeling Experiments for Metabolic Flux Analysis

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EMUlator: An Elementary Metabolite Unit (EMU) Based Isotope Simulator Enabled by Adjacency Matrix

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Metabolic flux analysis in adipose tissue reprogramming

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Simultaneous in vivo multi-organ fluxomics reveals divergent metabolic adaptations in liver, heart, and skeletal muscle during obesity

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Metabolic Flux Analysis: A Powerful Tool in Animal Cell Culture

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13C-metabolic flux analysis reveals metabolic rewiring in HL-60 neutrophil-like cells through differentiation and immune stimulation

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Nuclear magnetic resonance metabolic fingerprint of bevacizumab in mutant IDH1 glioma cells

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13C Flux Analysis in Biotechnology and Medicine

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Direct Infusion Mass Spectrometry to Rapidly Map Metabolic Flux of Substrates Labeled with Stable Isotopes

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Surface-Dependent Isotopic Adsorption of CO on α-Al2O3: Role of Weak Interactions and Zero-Point Energy

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Analyses of mitochondrial metabolism in diseases: a review on 13 C magnetic resonance tracers

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Targeted 13C-Labeled Tracer Fate Associations for Drug Efficacy Testing in Cancer

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Fructose Drives Glucose via Direct Oxidation and Promotes Palmitate/ Oleate Co-Release from Hepg2 Cells: Relevance with the Randle Cycle

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Fingerprinting eukaryotic metabolism across the animal kingdom using position-specific isotope analysis (PSIA) 13 C/ 12 C measurements

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Metabolic fluxes in recombinant Streptomyces lividans analyzed with 13 C-based metabolic flux analysis

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Modeling framework for isotopic labeling of heteronuclear moieties

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Systems-Level Analysis of Cancer Metabolism

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Metabolomics and fluxomics in biotechnology: current trends

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Fluxomics

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Combined Analysis of NMR and MS Spectra (CANMS)

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Automated analysis for multiplet identification from ultra-high resolution 2D-1H,13C-HSQC NMR spectra

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Kinetic isotope effects significantly influence intracellular metabolite [superscript 13]C labeling patterns and flux determination

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Mass Spectrometric Detection for Chromatography

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Customization of 13C-MFA Strategy According to Cell Culture System

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THE EFFECTS OF METFORMIN ON PANCREATIC CANCER METABOLISM

Cantoria, M. J. (2014) · UA Campus Repository (The University of Arizona) · Cited by 2

Applications of Metabolomics to the Clinical Management of Breast Cancer: New Perspectives for Diagnosis, Treatment and Prognosis

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Isotopic Tracing of [13C6] scyllo -Inositol Uncovers Its Incorporation into Phosphatidylinositols in Immortalized Mammalian Cells

Amma, M. K. P., Kollipara, L., Dürr‐Mayer, T., Streeck, J., Schmieder, P., Saiardi, A., Jessen, H. J., Heiles, S., & Fiedler, D. (2026) · ACS Chemical Biology · doi:10.1021/acschembio.6c00409 · Cited by 1

Carbon-13 and Its Clinical Application

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Stoichiometric Modeling of Oxygen Transportation through the Surface of Isolated Perfused Rat Liver

Викторович, Ш. К. (2016) · Mathematical Biology and Bioinformatics · doi:10.17537/2016.11.263 · Cited by 1

Glucose Metabolism Imaging

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Stochastic simulation algorithm for isotope-based dynamic flux analysis

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Development of a Dynamic Model to Describe CHO cells Metabolic Network and Regulation

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Reconstruction and analysis of central metabolism for the thermophilic bacterium Thermus thermophilus

Swarup, A. (2010) · Library, Museums and Press - UDSpace (University of Delaware) · Cited by 1

Host Organisms: Mammalian Cells

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Altered Glutamine Metabolism Exposes EMT Derived Mesenchymal Cells to PI3K/Akt/mTOR Pathway InhibitionPreprint

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Investigation of mammalian cell metabolism by quantification of key metabolic enzyme activities

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Multinuclear NMR Spectroscopy of Myocardial Energetics and Substrate Utilization in Isolated Perfused Mouse Hearts

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Silec: A New Tool to Study Mitochondrial and Metabolic Disease

Basu, S. S. (2012) · ScholarlyCommons (University of Pennsylvania)

NMR-based Metabolic Phenotyping for Disease Diagnosis and Stratification

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Melhoramento da eficiência de produção de polihidroxialcanoatos por Pseudomonas sp. através da análise molecular e modificação genética.

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Bioinformatics analysis of control mechanisms of burn and sepsis induced inflammatory response

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Stable isotope labeled metabolomics improves identification of novel metabolites and pathways "The recent surge in bioanalytical and bioinformatics methods developed for metabolomics studies have significantly improved our ability to expand isotope-labeling studies ... bringing us closer to the promise of a true systems biology understanding of the metabolism for many organisms."

Creek, D. J. (2013)

Residual breast cancer metabolic phenotype after docetaxel treatment

Volpari, T. (2016) · University of Birmingham Institutional Research Archive (University of Birmingham)

DYNAMICS IN THE CENTRAL PLANT CELL METABOLISM

Ampofo‐Asiama, J. (2014)

Using [U-13C6]-Glucose Tracer to Study Metabolic Changes in Oncogene-Induced Senescence Fibroblasts

Leonova, K. I., & Scott, D. A. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6670-7_11

Solution state nuclear magnetic resonance spectroscopy for biological metabolism and pathway intermediate analysis

Nealon, G. L., & Howard, M. J. (2016) · Essays in Biochemistry · doi:10.1042/ebc20160044

Novel strategies for validating metabolic network models using stable isotope tracers

Au, J. (2024) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/n635-c256

Transcriptômica e metabolômica como ferramentas para o entendimento do processo de adaptação metabólica tumoral dos tumores de mama triplo-negativo

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Systems Biology Approach to Study Cancer Metabolism

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Current Awareness in Labelled Compounds and Radiopharmaceuticals

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Faculty Opinions recommendation of Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.

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Application of nuclear magnetic resonance spectroscopy for the detection of metabolic changes in blood cells with defective DNA repair

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Data from LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

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Data from LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma

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Data from EMT-Derived Alterations in Glutamine Metabolism Sensitize Mesenchymal Breast Cells to mTOR Inhibition

Karvelsson, S. T., Sigurdsson, A., Seip, K., Grinde, M. T., Wang, Q., Jóhannsson, F., Mælandsmo, G. M., Moestue, S. A., Rolfsson, Ó., & Halldórsson, S. (2023) · doi:10.1158/1541-7786.c.6544989.v1

Metabolic Fluxes in the Renal Cortex are Dysregulated In Vivo in Response to High-Fat Diet

Hasenour, C. M., Banerjee, D. R., & Young, J. D. (2024) · doi:10.2337/figshare.25418308

Metabolic Fluxes in the Renal Cortex are Dysregulated In Vivo in Response to High-Fat Diet

Hasenour, C. M., Banerjee, D. R., & Young, J. D. (2024) · doi:10.2337/figshare.25418308.v1

Methods for Coenzyme II Assessment

Koju, N., & Sheng, R. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_14

The power of trapped ion mobility for isotope tracer experiments

Preindl, K., Chen, C., Murthy, S., Грубер, Ф., Freystätter, C., Weichhart, T., Stimpfl, T., Reiter, B., Haschemi, A., & Koellensperger, G. (2025) · Analytica Chimica Acta · doi:10.1016/j.aca.2025.344005

Comprehensive Characterization of an Inducible Mammalian Expression System Using 13C-Metabolic Flux Analysis

Sheikholeslami, Z. (2013) · PolyPublie (École Polytechnique de Montréal)

The study of RAS-induced metabolic reprogramming and the role of the pentose phosphate pathway in tumor metabolism

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Additional file 1 of Hot isopropanol quenching procedure for automated microtiter plate scale 13C-labeling experiments

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Investigating overflow metabolism in heterotrophic cultures of the green alga Chromochloris zofingiensis

Meagher, M., Camacho, D. J., Gallaher, S. D., Merchant, S., & Boyle, N. R. (2026) · Metabolic Engineering · doi:10.1016/j.ymben.2026.01.007

A proteomic approach for understanding the metabolic adaptations in non-small cell lung cancer

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Improving Isotope Ratio Accuracy in Metabolic Labeling Using Orbitrap Mass Spectrometry: A Machine Learning Correction Algorithm for Metabolic Flux Analysis

Yu, Z., Ziari, N., & Hellerstein, M. K. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c06638

Mass Spectrometry as a Tool for Metabolomics in Cancer

Patrício, J. S., Guerreiro, A. C. L., Gameiro, P. A., & Morelló, J. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-12166-0_19

Stable Isotope‐Resolved Metabolomics in Elucidating Mitochondrial Metabolic Reprogramming and Therapeutic Targets

Yang, D., Wu, X., Luo, X., Teng, Y., Duan, X., Kang, T., & Wu, W. (2026) · Biomedical Chromatography · doi:10.1002/bmc.70560

OpenMebius2: GUI-based software for 13C-metabolic flux analysis with tracer labeling pattern suggestions for precise flux predictions

Imada, T., Shimizu, H., & Toya, Y. (2026) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbag119

Metabolic flux analysis of neural cell metabolism in primary cultures

Amaral, A. I. (2011) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Optimization of [superscript 13]C isotopic tracers for metabolic flux analysis in mammalian cells

Walther, J. L., Metallo, C. M., Zhang, J., & Stephanopoulos, G. N. (2011) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 1

Optimization of 13C isotopic tracers for metabolic flux analysis in mammalian cells

Walther, J. L., Metallo, C. M., Zhang, J., & Stephanopoulos, G. N. (2011) · Metabolic Engineering · doi:10.1016/j.ymben.2011.12.004 · Cited by 81

Rational design of 13C-labeling experiments for metabolic flux analysis in mammalian cells

Crown, S. B., Ahn, W. S., & Antoniewicz, M. R. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-43 · Cited by 99

Using Multiple Tracers for 13C Metabolic Flux Analysis

Antoniewicz, M. R. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-299-5_17 · Cited by 16

Dissecting Mammalian Cell Metabolism through 13C- and 2H-Isotope Tracing: Interpretations at the Molecular and Systems Levels

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