Improved lactic acid productivity by an open repeated batch fermentation system using Enterococcus mundtii QU 25
Abstract
Decreasing the production cost of polymer-grade lactic acid is a challenge that the polylactic acid industry must surmount to be competitive with producers of petrochemical-derived plastics. In this study, we aimed to improve lactic acid productivity by investigating different fermentation systems. Enterococcus mundtii QU 25, previously reported by our group as a thermotolerant lactic acid bacterium, homofermentatively metabolizes glucose with the production of high optically pure L-lactic acid. The strain showed high lactic acid concentration and yield by controlled pH (7.0) and at a high temperature (43 °C). In a batch fermentation system, the optimal initial glucose concentration was 100 g L−1, at which high cell mass was achieved with production of 82.4 g L−1 of lactic acid at yield of 0.858 g g−1 glucose consumed. However, the productivity was approximately 2.0 g L−1 h−1. Subsequently, open repeated batch or fed-batch fermentation with recycled cells of the previous fermentation was conducted for 11 runs to enhance the productivity. As a result, lactic acid productivity was enhanced-up to 5.5-fold higher than that of the conventional batch culture, and fermentation was completed within 6 h with almost the same yield (0.761–0.832 g g−1 glucose consumed) and lactic acid concentration (81.6–84.5 g L−1). Up to 132 g L−1 lactic acid at yield of 0.853 g g−1 glucose consumed and productivity of 6.99 g L−1 h−1 were obtained in open repeated fed-batch fermentation. This indicates that strain QU 25 has the potential for industrial-scale production of lactic acid due to its high productivity, high yield of substrate conversion, and high final concentration of lactic acid produced under non-sterile conditions.
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PLA is considered the most promising biodegradable polymer material on the market.
“Given the problem of global pollution, focusing on improving the environment is a win–win situation; thus, it is considered the most promising biodegradable polymer material on the market [6,7].”
From Synthesis and Biological Application of Polylactic Acid (2020) · cites this paper as [6]
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Irsai, I., Pesek, S., & Silaghi-Dumitrescu, R. L. (2023) · Revue Roumaine de Chimie · doi:10.33224/rrch.2023.68.9.08
- Authors
- Abdel-Rahman, M. A., Tashiro, Y., Zendo, T., & Sonomoto, K.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Sonomoto, Kenji
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 3
- Issue
- 22
- Pages
- 8437
- ISSN
- 2046-2069 (ISSN-L)
- OpenAlex
- W2102455807
- Cited by
- 67
- References
- 38
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 1
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- RSC Advances (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Keywords
- lactic acid production, Enterococcus mundtii, fed-batch fermentation, L-lactic acid, polylactic acid, lactic acid productivity, cell recycling
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