Dealcoholized Red Wine Decreases Systolic and Diastolic Blood Pressure and Increases Plasma Nitric Oxide: Short Communication
Abstract
Rationale: Experimental studies have shown a potential blood pressure (BP) lowering effect of red wine polyphenols, whereas the effects of ethanol and polyphenols on BP in humans are not yet clear. Objective: The aim of the present work was to evaluate the effects of red wine fractions (alcoholic and nonalcoholic) on BP and plasma nitric oxide (NO) in subjects at high cardiovascular risk. Methods and Results: Sixty-seven men at high cardiovascular risk were studied. After a 2-week run-in period, subjects were randomized into 3 treatment periods in a crossover clinical trial, with a common background diet plus red wine (30g alcohol/day), the equivalent amount of dealcoholized red wine, or gin (30g alcohol/day), lasting 4 weeks each intervention. At baseline and after each intervention, anthropometrical parameters, BP and plasma NO were measured. Systolic and diastolic BP decreased significantly after the dealcoholized red wine intervention and these changes correlated with increases in plasma NO. Conclusions: Dealcoholized red wine decreases systolic and diastolic BP. Our results point out through an NO-mediated mechanism. The daily consumption of dealcoholized red wine could be useful for the prevention of low to moderate hypertension. Trial registered at controlled-trials.com : ISRCTN88720134.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dietary polyphenols from sources including cocoa and dealcoholized red wine are linked to improved vascular function.
“Dietary interventions have indicated improved vascular function linked to the consumption of polyphenols from different sources, including cocoa and dealcoholized red wine (60, 168, 225, 417, 834).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [168]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Colorimetry of Total Phenolics with Phosphomolybdic-Phosphotungstic Acid Reagents
Singleton, V. L., & Rossi, J. A. (1965) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1965.16.3.144 · Cited by 24,852 · see citing works
Ronksley, P. E., Brien, S. E., Turner, B. J., Mukamal, K. J., & Ghali, W. A. (2011) · BMJ · doi:10.1136/bmj.d671 · Cited by 1,610 · see citing works
Effects of Alcohol Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
Xin, X., He, J., Frontini, M. G., Ogden, L. G., Motsamai, O. I., & Whelton, P. K. (2001) · Hypertension · doi:10.1161/hy1101.093424 · Cited by 738 · see citing works
Validation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish Men
Elosua, R., Marrugat, J., Molina, L., Pons, S., & Pujol, E. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116966 · Cited by 499 · see citing works
Piceid, the Major Resveratrol Derivative in Grape Juices
Romero‐Pérez, A. I., Ibern-Gómez, M., Lamuela-Raventós, R. M., & de la Torre-Boronat, M. C. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981024g · Cited by 287 · see citing works
Wine Polyphenols Decrease Blood Pressure, Improve NO Vasodilatation, and Induce Gene Expression
Diebolt, M., Bucher, B., & Andriantsitohaina, R. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.159 · Cited by 239 · see citing works
Schröder, H., Covas, M.-I., Marrugat, J., Vila, J., PENA, A., Alcantara, M., & Masià, R. (2001) · Clinical Nutrition · doi:10.1054/clnu.2001.0460 · Cited by 232 · see citing works
Relationship of Alcohol Drinking Pattern to Risk of Hypertension
Stranges, S., Wu, T., Dorn, J. M., Freudenheim, J. L., Muti, P. C., Farinaro, E., Russell, M., Nochajski, T. H., & Trevisan, M. (2004) · Hypertension · doi:10.1161/01.hyp.0000146537.03103.f2 · Cited by 192 · see citing works
Chiva‐Blanch, G., Urpí-Sardà, M., Llorach, R., Rotchés-Ribalta, M., Guillén, M., Casas, R. M., Arranz, S., Valderas-Martínez, P., Portolés, O., Corella, D., et al. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.022889 · Cited by 184 · see citing works
Self-citationHuang, P., Chen, Y., Tsai, H., Chen, J.-S., Wu, T.-C., Lin, F., Sata, M., Chen, J., & Lin, S. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.200618 · Cited by 145 · see citing works
Beyond salt: lifestyle modifications and blood pressure
Frisoli, T., Schmieder, R. E., Grodzicki, T. K., & Messerli, F. H. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr379 · Cited by 136 · see citing works
Zamora‐Ros, R., Urpí-Sardà, M., Lamuela-Raventós, R. M., Estruch, R., Martínez‐González, M. Á., Bulló, M., Arós, F., Cherubini, A., & Andrés‐Lacueva, C. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.023 · Cited by 108 · see citing works
Self-citationHPLC–Tandem Mass Spectrometric Method to Characterize Resveratrol Metabolism in Humans
Urpí-Sardà, M., Zamora‐Ros, R., Lamuela-Raventós, R. M., Cherubini, A., Jáuregui, O., de la Torre, R., Covas, M. I., Estruch, R., Jaeger, W., & Andrés‐Lacueva, C. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.071936 · Cited by 105 · see citing works
Self-citationRapid HPLC Analysis of Phenolic Compounds in Red Wines
Ibern-Gómez, M., Andrés‐Lacueva, C., Lamuela-Raventós, R. M., et al. (2002) · American Journal of Enology and Viticulture · doi:10.5344/ajev.2002.53.3.218 · Cited by 79 · see citing works
Botden, I. P. G., Draijer, R., Westerhof, B. E., Rutten, J. H. W., Langendonk, J. G., Sijbrands, E. J. G., Danser, A. H. J., Zock, P. L., & van den Meiracker, A. H. (2012) · American Journal of Hypertension · doi:10.1038/ajh.2012.25 · Cited by 37 · see citing works
Okubo, Y., Suwazono, Y., Kobayashi, E., & Nogawa, K. (2001) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001191 · Cited by 37 · see citing works
Botden, I. P. G., Langendonk, J. G., Meima, M. E., et al. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.227 · Cited by 29 · see citing works
Andersen, U. O., & Jensen, G. B. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.01.008 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Strategies to increase nitric oxide signalling in cardiovascular disease
Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4623 · Cited by 576 · see citing works
Roerecke, M., Kaczorowski, J., Tobe, S. W., Gmel, G., Hasan, O. S. M., & Rehm, J. (2017) · The Lancet Public Health · doi:10.1016/s2468-2667(17)30003-8 · Cited by 552 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
Alcohol and Cardiovascular Health: The Dose Makes the Poison…or the Remedy
O’Keefe, J. H., Bhatti, S. K., Bajwa, A., DiNicolantonio, J. J., & Lavie, C. J. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.11.005 · Cited by 406 · see citing works
Salehi, B., Sharifi-Rad, J., Cappellini, F., Reiner, Ž., Zorzan, D., Imran, M., Sener, B., Kilic, M., El-Shazly, M., Fahmy, N. M., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01300 · Cited by 293 · see citing works
Adherence to Mediterranean Diet and All-Cause Mortality After an Episode of Acute Heart Failure
Miró, Ò., Estruch, R., Martín-Sánchez, F. J., Gil, V., Jacob, J., Herrero-Puente, P., Herrera Mateo, S., Aguirre, A., Andueza, J. A., Llorens, P., et al. (2018) · JACC: Heart Failure · doi:10.1016/j.jchf.2017.09.020 · Cited by 60 · see citing works
Self-citation
- Authors
- Chiva-Blanch, G., Urpi-Sarda, M., Ros, E., Arranz, S., Valderas-Martínez, P., Casas, R., Sacanella, E., Llorach, R., Lamuela-Raventos, R. M., Andres-Lacueva, C., & Estruch, R.
- Affiliations
- From the Department of Internal Medicine (G.C.-B., M.U.-S., S.A., P.V.-M., R.C., E.S., R.E.), Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain; CIBER de Fisiopatologia de la Obesidad y la Nutrición (G.C.-B., M.U.-S., E.R., S.A., P.V.-M., R.C., R.M.L.-R., R.E.), Instituto de Salud Carlos III (ISCIII), Spain; Lipid Clinic (E.R.), Endocrinology and Nutrition Service, IDIBAPS, Hospital Clinic, Barcelona, Spain; Nutrition and...
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Venue
- Circulation Research
- Published
- 2012-09-28
- Volume
- 111
- Issue
- 8
- Pages
- 1065-1068
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2116957504
- Cited by
- 146
- References
- 19
- Citations by year
- 2026: 2 · 2025: 12 · 2024: 11 · 2023: 9 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 16 · 2017: 8 · 2016: 13 · 2015: 17 · 2014: 13 · 2013: 13 · 2012: 4
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Funders
- Instituto de Salud Carlos III
- European Social Fund
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- red wine polyphenols, blood pressure, plasma nitric oxide, hypertension prevention, ethanol, gin, cardiovascular risk, systolic blood pressure, diastolic blood pressure
- MeSH terms
- Aged, Ethanol, Blood Pressure, Central Nervous System Depressants, Humans, Hypertension, Male, Middle Aged, Nitric Oxide, Risk Factors, Wine, Treatment Outcome, Cross-Over Studies, Risk Reduction Behavior, Polyphenols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
