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Interleukin-6 in Patients With Heart Failure and Preserved Ejection Fraction
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As compared with nonobese HFpEF, patients with obesity-related HFpEF display distinct pathophysiologic features, including greater volume expansion, more severe inflammation, increases in visceral and paracardiac adipose tissue and more severe myocardial injury.
“As compared with nonobese HFpEF, patients with obesity-related HFpEF display distinct pathophysiologic features, including greater volume expansion5,17, more severe inflammation6,7, increases in visceral and paracardiac adipose tissue5,15,18,19 and more severe myocardial injury15.”
Individuals with obesity-related HFpEF have a high burden of hypertension and chronic kidney disease, which develops in response to marked blood volume expansion and chronic systemic inflammation.
“Individuals with obesity-related HFpEF have a high burden of hypertension and chronic kidney disease (CKD), which develops in response to marked blood volume (BV) expansion and chronic systemic inflammation5–8.”
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Citations
Cites
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
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Self-citationObesity, venous capacitance, and venous compliance in heart failure with preserved ejection fraction
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Self-citationAlehagen, U., Benson, L., Edner, M., Dahlström, U., & Lund, L. H. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002143 · Cited by 109
Flagged first, then by citations
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Cited by
Sorted by citations
Borlaug, B. A., Zile, M. R., Kramer, C. M., Baum, S. J., Hurt, K., Litwin, S. E., Murakami, M., Ou, Y., Upadhyay, N., & Packer, M. (2025) · Nature Medicine · doi:10.1038/s41591-024-03374-z · Cited by 166
Self-citationSemaglutide and NT-proBNP in Obesity-Related HFpEF
Petrie, M. C., Borlaug, B. A., Butler, J., Davies, M. J., Kitzman, D. W., Shah, S. J., Verma, S., Jensen, T. J., Einfeldt, M. N., Liisberg, K., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.04.022 · Cited by 95
Self-citationVerma, R., Dhingra, N. K., & Connelly, K. A. (2024) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000001113 · Cited by 24
Metadata
- Authors
- Alogna, A., Koepp, K. E., Sabbah, M., Espindola Netto, J. M., Jensen, M. D., Kirkland, J. L., Lam, C. S. P., Obokata, M., Petrie, M. C., Ridker, P. M., Sorimachi, H., Tchkonia, T., Voors, A., Redfield, M. M., & Borlaug, B. A.
- Venue
- JACC: Heart Failure
- Publisher
- Elsevier BV
- Published
- 2023-11
- Volume
- 11
- Issue
- 11
- Pages
- 1549-1561
- ISSN
- 2213-1779
- PMC
- PMC10895473
- Cited by
- 142
- References
- 7
- Language
- en
- Licence
- Funders
- NHLBI
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