Recent progress in biomedical applications of pluronic (PF127): Pharmaceutical perspectives

Akash, Muhammad Sajid Hamid; Rehman, Kanwal

doi:10.1016/j.jconrel.2015.04.032

Cited by 394Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsDrug Solubulity and Delivery Systems

Recent progress in biomedical applications of pluronic (PF127): Pharmaceutical perspectives

Akash, Muhammad Sajid Hamid, Rehman, Kanwal·2015·Journal of Controlled Release

DOI 10.1016/j.jconrel.2015.04.032

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Abstract

Most of the administered anti-cancer drugs are hydrophobic in nature and are known to have poor water solubility, short residence time, rapid clearance from the body and systemic side effects. Polymeric-based targeted particulate carrier system has shown to directly deliver the encapsulated anti-cancer drug to the desired site of action and prevent the interaction of encapsulated drug with the normal cells. Pluronic F127 (PF127) has been widely investigated for its broad-range of therodiagnostic applications in biomedical and pharmaceutical sciences, but rapid dissolution in the physiological fluids, short residence time, rapid clearance, and weak mechanical strength are the main shortcomings that are associated with PF127 and have recently been overcome by making various modifications in the structure of PF127 notably through preparation of PF127-based mixed polymeric micelles, PF127-conjugated nanoparticles and PF127-based hydrophobically modified thermogels. In this article, we have briefly discussed the recent studies that have been conducted on various anti-cancer drugs using PF127 as nano-carrier modified with other copolymers and/or conjugated with magnetic nanoparticles. The key findings of these studies demonstrated that the modified form of PF127 can significantly increase the stability of incorporated hydrophobic drugs with enhanced in vitro cytotoxicity and cellular uptake of anti-cancer drugs. Moreover, the modified form of PF127 has also shown its therapeutic potentials as therodiagnostics in various types of tumors and cancers. Hence, it can be concluded that the modified form of PF127 exhibits significant therodiagnostic effects with increased tumor-specific delivery of anti-cancer drugs having minimal toxic effects as compared to PF127 alone and/or other copolymers.

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PF127 is approved by the U.S. Food and Drug Administration for use in biomedical areas, especially drug delivery, tissue engineering, and administration of PF127-based drug delivery systems by oral, ocular, intranasal, subcutaneous, vaginal, and rectal routes.
“PF127 is approved by the ‘U.S. Food and Drug Administration’ (FDA) to be used in biomedical areas especially for drug delivery, tissue engineering, and the administration of the PF127-based drug delivery system, which can be oral, ocular, intranasal, subcutaneous, vaginal, and rectal [95].”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [95]
PF127 is a non-ionic triblock copolymer of PEO-PPO-PEO and, being a thermo-responsive synthetic polymer, can form hydrogel near body temperature.
“Pluronic F127 (PF127) is a non-ionic triblock copolymer of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO) and, being a thremo-responsive synthetic polymer, PF127 can form the hydrogel near the body temperature [35,95].”
From Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application (2019) · cites this paper as [95]

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Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application
CHATTERJEE, S., & Chi-leung HUI, P. (2019) · Molecules · doi:10.3390/molecules24142547 · Cited by 201 · see citing works
“Pluronic F127 (PF127) is a non-ionic triblock copolymer of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO) and, being a thremo-responsive synthetic polymer, PF127 can form the hydrogel near the body temperature [35,95].”
Background
Thermoresponsive Hydrogels and Their Biomedical Applications: Special Insight into Their Applications in Textile Based Transdermal Therapy
Chatterjee, S., Hui, P. C.-L., & Kan, C.-W. (2018) · Polymers · doi:10.3390/polym10050480 · Cited by 196 · see citing works

Authors: Akash, M. S. H., & Rehman, K.
Affiliations: Government College University, Faisalabad (PK)
University of Agriculture Faisalabad (PK)
Corresponding author: Akash, Muhammad Sajid Hamid
Rehman, Kanwal
ORCID: Akash, Muhammad Sajid Hamid
Rehman, Kanwal
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2015-07
Volume: 209
Pages: 120-138
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2015.04.032
OpenAlex: W2026010448
Cited by: 394
References: 235
Citations by year: 2026: 31 · 2025: 51 · 2024: 43 · 2023: 45 · 2022: 30 · 2021: 44 · 2020: 45 · 2019: 26 · 2018: 34 · 2017: 25 · 2016: 17 · 2015: 3
FWCI: 1.59
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords: Pluronic F127, polymeric micelles, anticancer drug delivery, hydrophobic drug solubilization, theranostics, tumor-specific drug delivery, cellular uptake, drug stability, thermosensitive hydrogel, copolymers
MeSH terms: Animals, Antineoplastic Agents, Drug Carriers, Gels, Humans, Micelles, Poloxamer, Nanoparticles

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Recent progress in biomedical applications of pluronic (PF127): Pharmaceutical perspectives

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