Polymeric micelles drug delivery system in oncology

Gong, Jian; Chen, Meiwan; Zheng, Ying; Wang, Shengpeng; Wang, Yitao

doi:10.1016/j.jconrel.2011.12.012

Cited by 570Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsDrug Transport and Resistance Mechanisms

Polymeric micelles drug delivery system in oncology

Gong, Jian, Chen, Meiwan, Zheng, Ying, Wang, Shengpeng, Wang, Yitao·2012·Journal of Controlled Release

DOI 10.1016/j.jconrel.2011.12.012

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Abstract

Polymeric micelles (PM) system, as an efficient drug carrier, has received growing scientific attention in recent years owing to its solubilization, selective targeting, P-glycoprotein inhibition and altered drug internalization route and subcellular localization properties. Seven PM formulations of anti-tumor drugs being evaluated in clinical trials are reviewed in this paper, in terms of formulation study, in vitro cytotoxicity, in vivo pharmacokinetics, anti-tumor efficacy and safety as well as clinical trials, to shed new light on the discovery of novel PM formulations. In these seven PM formulations, PM system was employed to overcome the issues of low water solubility, high toxicity and (or) multidrug resistance accompanied with the conventional formulation, which greatly hampered their clinical application. Those promising preclinical and clinical results combined with rapid advancement and intense multidisciplinary collaboration enable the extension of the PM system to traditional Chinese medicine, imaging agents, gene and combination agent deliveries as well as some other administration routes, which facilitate the clinical translation of the PM drug delivery system.

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Nanomicelles have received tremendous interest in nanomedicine due to their low-cost, great biocompatibility, simple preparation methods, and effectiveness.
“Among these DDSs, nanomicelles have received tremendous interest in nanomedicine due to their low-cost, great biocompatibility, simple preparation methods, and effectiveness [8].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [8]

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Authors: Gong, J., Chen, M., Zheng, Y., Wang, S., & Wang, Y.
Affiliations: University of Macau (MO)
Corresponding author: Wang, Yitao
ORCID: Gong, Jian
Chen, Meiwan
Zheng, Ying
Wang, Shengpeng
Wang, Yitao
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2012-05
Volume: 159
Issue: 3
Pages: 312-323
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2011.12.012
OpenAlex: W2142897044
Cited by: 570
References: 114
Citations by year: 2026: 15 · 2025: 30 · 2024: 33 · 2023: 36 · 2022: 38 · 2021: 41 · 2020: 42 · 2019: 34 · 2018: 34 · 2017: 46 · 2016: 66 · 2015: 40 · 2014: 54 · 2013: 47 · 2012: 13
FWCI: 2.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Funders: Macau Special Administrative Region (029/2007/A2)
University of Macau (UL016A/09-Y2/CMS/WYT01/ICMS)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: polymeric micelles, drug delivery systems, anticancer agents, multidrug resistance, P-glycoprotein inhibition, drug solubilization, pharmacokinetics, cytotoxicity, clinical translation, gene delivery, combination drug delivery
MeSH terms: Animals, Antineoplastic Agents, Cell Survival, Clinical Trials as Topic, Drug Carriers, Drug Stability, Humans, Micelles, Neoplasms, Polymers, Drug Delivery Systems, Cell Line, Tumor

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Polymeric micelles drug delivery system in oncology

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