Exploring Polymeric Micelles for Improved Delivery of Anticancer Agents: Recent Developments in Preclinical Studies

Integrins in cancer: biological implications and therapeutic opportunities

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The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

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Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery

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Multifunctional nanocarriers☆

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Folate-mediated delivery of macromolecular anticancer therapeutic agents

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Block copolymer micelles as long-circulating drug vehicles

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The transferrin receptor and the targeted delivery of therapeutic agents against cancer

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Current prospects for RNA interference-based therapies

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Polymeric micelles drug delivery system in oncology

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A tumor-homing peptide with a targeting specificity related to lymphatic vessels

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Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances

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Simultaneous Delivery of siRNA and Paclitaxel via a “Two-in-One” Micelleplex Promotes Synergistic Tumor Suppression

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Cyclic RGD conjugated poly(ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect

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Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors

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Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer

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Multifunctional nanocarriers

Torchilin, V. P. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.031 · Cited by 342 · see citing works

Multifunctional Micellar Nanomedicine for Cancer Therapy

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Well-defined, reversible disulfide cross-linked micelles for on-demand paclitaxel delivery

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Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(β-amino ester) block copolymer micelles for cancer therapy

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Tumoral acidic pH-responsive MPEG-poly(β-amino ester) polymeric micelles for cancer targeting therapy

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Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells.

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Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin

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Folate-mediated delivery of macromolecular anticancer therapeutic agents

Lu, Y. J., & Low, P. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.020 · Cited by 266 · see citing works

Potential efficacy of cell-penetrating peptides for nucleic acid and drug delivery in cancer

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Covalently cross-linked amphiphilic block copolymer micelles

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Improving Penetration in Tumors With Nanoassemblies of Phospholipids and Doxorubicin

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Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy

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A self-assembling nanoparticle for paclitaxel delivery in ovarian cancer

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Polymeric micelles from poly (ethylene glycol)–poly (amino acid) block copolymer for drug and gene delivery

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Tumor accumulation and antitumor efficacy of docetaxel-loaded core-shell-corona micelles with shell-specific redox-responsive cross-links

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Targeted Polymeric Micelles for siRNA Treatment of Experimental Cancer by Intravenous Injection

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In Vivo Evaluation of Doxorubicin-Loaded Polymeric Micelles Targeting Folate Receptors and Early Endosomal pH in Drug-Resistant Ovarian Cancer

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The effects of mixed MPEG–PLA/Pluronic® copolymer micelles on the bioavailability and multidrug resistance of docetaxel

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Block copolymer micelles as long-circulating drug vehicles

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Peptide-Mediated Targeting to Tumor Blood Vessels of Lung Cancer for Drug Delivery

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Two in one

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Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: Synthesis, preparation and in vivo evaluation

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Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles

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Dual chemotherapy and photodynamic therapy in an HT-29 human colon cancer xenograft model using SN-38-loaded chlorin-core star block copolymer micelles

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β-Lapachone Micellar Nanotherapeutics for Non–Small Cell Lung Cancer Therapy

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Somatostatin receptor-targeted anti-cancer therapy.

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A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy

Mao, C., Du, J., Sun, T., Yao, Y., Zhang, P., Song, E., & Wang, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.006 · Cited by 115 · see citing works

The potential of Pluronic polymeric micelles encapsulated with paclitaxel for the treatment of melanoma using subcutaneous and pulmonary metastatic mice models

Zhang, W., Shi, Y., Chen, Y., Hao, J., Sha, X., & Fang, X. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.075 · Cited by 111 · see citing works

PEG-oligocholic acid telodendrimer micelles for the targeted delivery of doxorubicin to B-cell lymphoma

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Blood-stable, tumor-adaptable disulfide bonded mPEG-(Cys)4-PDLLA micelles for chemotherapy

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Enhanced antitumor effect of camptothecin loaded in long-circulating polymeric micelles

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Graft and diblock copolymer multifunctional micelles for cancer chemotherapy and imaging

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Paclitaxel-loaded polymeric micelles based on poly(ɛ-caprolactone)-poly(ethylene glycol)-poly(ɛ-caprolactone) triblock copolymers: in vitro and in vivo evaluation

Zhang, L., He, Y., Ma, G., Song, C. X., & Sun, H. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2011.11.005 · Cited by 93 · see citing works

“OA02” Peptide Facilitates the Precise Targeting of Paclitaxel-Loaded Micellar Nanoparticles to Ovarian Cancer In Vivo

Xiao, K., Li, Y., Lee, J. S., Gonik, A. M., Dong, T., Fung, G., Sanchez, E., Li, X., Cheng, H. R., Luo, J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3883 · Cited by 90 · see citing works

Antiangiogenic gene therapy of experimental pancreatic tumor by sFlt-1 plasmid DNA carried by RGD-modified crosslinked polyplex micelles

Vachutinsky, Y., Oba, M., Miyata, K., Hiki, S., Kano, M. R., Nishiyama, N., Koyama, H., Miyazono, K., & Kataoka, K. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.002 · Cited by 88 · see citing works

Enhanced cytotoxicity of TATp-bearing paclitaxel-loaded micelles in vitro and in vivo

Sawant, R. R., & Torchilin, V. P. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.02.022 · Cited by 78 · see citing works

Antiangiogenic Gene Therapy of Solid Tumor by Systemic Injection of Polyplex Micelles Loading Plasmid DNA Encoding Soluble Flt-1

Oba, M., Vachutinsky, Y., Miyata, K., Kano, M. R., Ikeda, S., Nishiyama, N., Itaka, K., Miyazono, K., Koyama, H., & Kataoka, K. (2010) · Molecular Pharmaceutics · doi:10.1021/mp9002317 · Cited by 70 · see citing works

LyP-1 Modification To Enhance Delivery of Artemisinin or Fluorescent Probe Loaded Polymeric Micelles to Highly Metastatic Tumor and Its Lymphatics

Wang, Z., Yu, Y., Ma, J., Zhang, H., Zhang, H., Wang, X., Wang, J., Zhang, X., & Zhang, Q. (2012) · Molecular Pharmaceutics · doi:10.1021/mp3002107 · Cited by 66 · see citing works

Improved Photodynamic Cancer Treatment by Folate‐Conjugated Polymeric Micelles in a KB Xenografted Animal Model

Syu, W., Yu, H., Hsu, C., Rajan, Y. C., Hsu, Y., Chang, Y., Hsieh, W., Wang, C., & Lai, P. (2012) · Small · doi:10.1002/smll.201102695 · Cited by 66 · see citing works

Small-Interfering RNA (siRNA)-Based Functional Micro- and Nanostructures for Efficient and Selective Gene Silencing

Hyeon, L. S., Chung, B. H., Park, T. G., Nam, Y. S., & Mok, H. (2012) · Accounts of Chemical Research · doi:10.1021/ar2002254 · Cited by 63 · see citing works

Enhanced antitumor efficacy and decreased toxicity by self-associated docetaxel in phospholipid-based micelles

Tong, S.-W., Xiang, B., Dong, D., & Qi, X. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.06.014 · Cited by 61 · see citing works

Poly(caprolactone)-modified Pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors

Wang, Y., Hao, J., Li, Y., Zhang, Z., Sha, X., Han, L., & Fang, X. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.03.013 · Cited by 59 · see citing works

Engineered Nanoscaled Polyplex Gene Delivery Systems

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Potent Retro-Inverso d -Peptide for Simultaneous Targeting of Angiogenic Blood Vasculature and Tumor Cells

Li, Y., Yang, L., Wagner, E., Xie, C., Lu, W., Zhu, J., Shen, J., Wang, J., & Liu, M. (2012) · Bioconjugate Chemistry · doi:10.1021/bc300537z · Cited by 57 · see citing works

Human Breast Carcinoma Cells Express Type II IL-4 Receptors and Are Sensitive to Antitumor Activity of a Chimeric IL-4-Pseudomonas Exotoxin Fusion Protein in vitro and in vivo

Leland, P., Taguchi, J., Husain, S. R., Kreitman, R. J., Pastan, I. H., & Puri, R. K. (2000) · Molecular Medicine · doi:10.1007/bf03402112 · Cited by 55 · see citing works

The antiangiogenic efficacy of NGR-modified PEG–DSPE micelles containing paclitaxel (NGR-M-PTX) for the treatment of glioma in rats

Zhao, B., Ke, X., Huang, Y. M., Chen, X., Zhao, X., Zhao, B., Lü, W.-L., Lou, J., Zhang, X., & Zhang, Q. (2010) · Journal of drug targeting · doi:10.3109/1061186x.2010.504267 · Cited by 48 · see citing works

Combined Delivery of Paclitaxel and Tanespimycin via Micellar Nanocarriers: Pharmacokinetics, Efficacy and Metabolomic Analysis

Katragadda, U., Fan, W. Q., Wang, Y., Teng, Q., & Tan, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058619 · Cited by 48 · see citing works

A Novel Lanreotide-Encoded Micelle System Targets Paclitaxel to the Tumors with Overexpression of Somatostatin Receptors

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Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles

Okuda, T., Kawakami, S., Higuchi, Y., Satoh, T., Oka, Y., Yokoyama, M., Yamashita, F., & Hashida, M. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.01.019 · Cited by 36 · see citing works

A novel micelle-encapsulated platinum(II) anticancer agent

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Stable and efficient delivery of docetaxel by micelle-encapsulation using a tripodal cyclotriphosphazene amphiphile

Jun, Y. J., Jadhav, V. B., Min, J. H., Cui, J. X., Chae, S. W., Choi, J. M., Kim, I., Choi, S., Lee, H. J., & Sohn, Y. S. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.10.052 · Cited by 34 · see citing works

Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination

Kumagai, M., Shimoda, S., Wakabayashi, R., Kunisawa, Y., Ishii, T., Osada, K., Itaka, K., Nishiyama, N., Kataoka, K., & Nakano, K. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.03.021 · Cited by 27 · see citing works

Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine

Lombardo, D., Kiselev, M. A., & Caccamo, M. T. (2019) · Journal of Nanomaterials · doi:10.1155/2019/3702518 · Cited by 864 · see citing works

Amphiphiles Self-Assembly: Basic Concepts and Future Perspectives of Supramolecular Approaches

Lombardo, D., Kiselev, M. A., Magazù, S., & Calandra, P. (2015) · Advances in Condensed Matter Physics · doi:10.1155/2015/151683 · Cited by 531 · see citing works

Indocyanine green delivery systems for tumour detection and treatments

Porcu, E. P., Salis, A., Gavini, E., Rassu, G., Maestri, M., & Giunchedi, P. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.04.001 · Cited by 213 · see citing works

Nanomedicines Based Drug Delivery Systems for Anti-Cancer Targeting and Treatment

Jain, V., Jain, S., & Mahajan, S. (2015) · Current Drug Delivery · doi:10.2174/1567201811666140822112516 · Cited by 162 · see citing works

Recent Advances in Nanomicelles Delivery Systems.

Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works

The Warburg effect and glucose-derived cancer theranostics

Tekade, R. K., & Sun, X. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.08.003 · Cited by 151 · see citing works

Drug and cell encapsulation: Alternative delivery options for the treatment of malignant brain tumors

Bhujbal, S. V., de Vos, P., & Niclou, S. P. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.01.010 · Cited by 116 · see citing works

Polymeric micelles as mighty nanocarriers for cancer gene therapy: a review

Yousefpour Marzbali, M., & Yari Khosroushahi, A. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-017-3273-1 · Cited by 115 · see citing works

Drug Loading and Release from Electrospun Biodegradable Nanofibers

Goonoo, N., Bhaw‐Luximon, A., & Jhurry, D. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2014.1885 · Cited by 107 · see citing works

Recent advances in drug delivery nanocarriers incorporated in temperature-sensitive Pluronic F-127–A critical review

J, R. J. P., Oluwafemi, O. S., Thomas, S., & Oyedeji, A. O. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103390 · Cited by 101 · see citing works

Poly(styrene-alt-maleic anhydride)-Based Diblock Copolymer Micelles Exhibit Versatile Hydrophobic Drug Loading, Drug-Dependent Release, and Internalization by Multidrug Resistant Ovarian Cancer Cells

Baranello, M. P., Bauer, L., & Benoit, D. S. W. (2014) · Biomacromolecules · doi:10.1021/bm500468d · Cited by 80 · see citing works

Rheumatiod Arthritis: An Updated Overview of Latest Therapy and Drug Delivery

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Novel pH-sensitive charge-reversal cell penetrating peptide conjugated PEG-PLA micelles for docetaxel delivery: In vitro study

Ouahab, A., Cheraga, N., Onoja, V., Shen, Y., & Tu, J. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.03.009 · Cited by 69 · see citing works

Polymeric nano-micelles: Versatile Platform for Targeted Delivery in Cancer

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Bisdemethoxycurcumin loaded polymeric mixed micelles as potential anti-cancer remedy: Preparation, optimization and cytotoxic evaluation in a HepG-2 cell model

Mehanny, M., Hathout, R. M., Geneidi, A. S., & Mansour, S. (2015) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2015.12.007 · Cited by 56 · see citing works

Dopamine Delivery via pH‐Sensitive Nanoparticles for Tumor Blood Vessel Normalization and an Improved Effect of Cancer Chemotherapeutic Drugs

Taleb, M., Ding, Y., Wang, B., Yang, N., Han, X., Du, C., Qi, Y., Zhang, Y., Sabet, Z. F., Alanagh, H. R., et al. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900283 · Cited by 53 · see citing works

Recent Progress of Crosslinking Strategies for Polymeric Micelles with Enhanced Drug Delivery in Cancer Therapy

Fan, W. Q., Zhang, L., Li, Y., & Wu, H. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666171121102255 · Cited by 52 · see citing works

Micelles as potential drug delivery systems for colorectal cancer treatment

Fatfat, Z., Fatfat, M., & Gali‐Muhtasib, H. U. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i25.2867 · Cited by 52 · see citing works

Self-assembling polymer systems for advanced treatment of cancer and inflammation

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Polymer Micelle Formulations of Proteasome Inhibitor Carfilzomib for Improved Metabolic Stability and Anticancer Efficacy in Human Multiple Myeloma and Lung Cancer Cell Lines

Ao, L., Reichel, D., Hu, D., Jeong, H., Kim, K. B., Bae, Y., & Lee, W. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.226993 · Cited by 46 · see citing works

Near-Infrared Light-Triggered Polymeric Nanomicelles for Cancer Therapy and Imaging

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Targeted doxorubicin nanotherapy strongly suppressing growth of multidrug resistant tumor in mice

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