The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Thermosensitive liposomes for localized delivery and triggered release of chemotherapy
Open accessAbstract
Liposomes are a promising class of nanomedicine with the potential to provide site-specific chemotherapy, thus improving the quality of cancer patient care. First-generation liposomes have emerged as one of the first nanomedicines used clinically for localized delivery of chemotherapy. Second-generation liposomes, i.e. stimuli-responsive liposomes, have the potential to not only provide site-specific chemotherapy, but also triggered drug release and thus greater spatial and temporal control of therapy. Temperature-sensitive liposomes are an especially attractive option, as tumors can be heated in a controlled and predictable manner with external energy sources. Traditional thermosensitive liposomes are composed of lipids that undergo a gel-to-liquid phase transition at several degrees above physiological temperature. More recently, temperature-sensitization of liposomes has been demonstrated with the use of lysolipids and synthetic temperature-sensitive polymers. The design, drug release behavior, and clinical potential of various temperature-sensitive liposomes, as well as the various heating modalities used to trigger release, are discussed in this review.
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Metadata
- Authors
- Ta, T., & Porter, T. M.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 169
- Issue
- 1-2
- Pages
- 112-125
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2000568918
- Cited by
- 403
- References
- 122
- FWCI
- 11.14
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
