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Hybrid nanoparticles for combination therapy of cancer
Open accessAbstract
Nanoparticle anticancer drug delivery enhances therapeutic efficacies and reduces side effects by improving pharmacokinetics and biodistributions of the drug payloads in animal models. Despite promising preclinical efficacy results, monotherapy nanomedicines have failed to produce enhanced response rates over conventional chemotherapy in human clinical trials. The discrepancy between preclinical data and clinical outcomes is believed to result from the less pronounced enhanced permeability and retention (EPR) effect in and the heterogeneity of human tumors as well as the intrinsic/acquired drug resistance to monotherapy over the treatment course. To address these issues, recent efforts have been devoted to developing nanocarriers that can efficiently deliver multiple therapeutics with controlled release properties and increased tumor deposition. In ideal scenarios, the drug or therapeutic modality combinations have different mechanisms of action to afford synergistic effects. In this review, we summarize recent progress in designing hybrid nanoparticles for the co-delivery of combination therapies, including multiple chemotherapeutics, chemotherapeutics and biologics, chemotherapeutics and photodynamic therapy, and chemotherapeutics and radiotherapy. The in vitro and in vivo anticancer effects are also discussed.
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“For instance, synthetic tunability enables the creation of smart nanoparticles that can simultaneously serve several therapeutic or imaging goals by co-encapsulating various therapeutic compounds with various release curves.22,23”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [23]
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Metadata
- Authors
- He, C., Lu, J., & Lin, W.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Lin, Wenbin
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 219
- Pages
- 224-236
- ISSN
- 0168-3659 (ISSN-L)
- PMC
- PMC4656047
- OpenAlex
- W1770290865
- Cited by
- 174
- References
- 108
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 19 · 2023: 13 · 2022: 13 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 9 · 2017: 20 · 2016: 12
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (U01-CA151455)
- University of Chicago Medicine Comprehensive Cancer Center (P30 CA014599)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Keywords
- hybrid nanostructures, combination cancer therapy, co-delivery, nanocarriers, drug resistance, enhanced permeability and retention effect, tumor heterogeneity, photodynamic therapy, radiotherapy, chemotherapeutics, biologics, controlled release, synergistic drug delivery
- MeSH terms
- Animals, Antineoplastic Agents, Drug Combinations, Ferric Compounds, Gold, Humans, Neoplasms, Organometallic Compounds, Polymers, Drug Delivery Systems, Organosilicon Compounds, Nanoparticles
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