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The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

Qi, Hongzhao, Liu, Chaoyong, Long, Lixia, Ren, Yu, Zhang, Shanshan, Chang, Xiaodan, Qian, Xiaomin, Jia, Huanhuan, Zhao, Jin, Sun, Jinjin, Hou, Xin, Yuan, Xubo, Kang, Chunsheng·2016·ACS Nano
DOI 10.1021/acsnano.5b06939
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Abstract

Exosomes are a class of naturally occurring nanoparticles that are secreted endogenously by mammalian cells. Clinical applications for exosomes remain a challenge because of their unsuitable donors, low scalability, and insufficient targeting ability. In this study, we developed a dual-functional exosome-based superparamagnetic nanoparticle cluster as a targeted drug delivery vehicle for cancer therapy. The resulting exosome-based drug delivery vehicle exhibits superparamagnetic behavior at room temperature, with a stronger response to an external magnetic field than individual superparamagnetic nanoparticles. These properties enable exosomes to be separated from the blood and to target diseased cells. In vivo studies using murine hepatoma 22 subcutaneous cancer cells showed that drug-loaded exosome-based vehicle delivery enhanced cancer targeting under an external magnetic field and suppressed tumor growth. Our developments overcome major barriers to the utility of exosomes for cancer application.

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Metadata

Authors
Qi, H., Liu, C., Long, L., Ren, Y., Zhang, S., Chang, X., Qian, X., Jia, H., Zhao, J., Sun, J., Hou, X., Yuan, X., & Kang, C.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2016-03-07
Volume
10
Issue
3
Pages
3323-3333
ISSN
  • 1936-0851
  • 1936-086X
DOI
10.1021/acsnano.5b06939
Cited by
459
References
2
Language
en
Funders
  • Ministry of Science and Technology of the People's Republic of China (2012AA02A508, 2014AA021102)
  • National Natural Science Foundation of China (51303125, 51473119)

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CoChat. (2026). Citation check: Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy. https://app.cochat.ai/papers/10.1021/acsnano.5b06939
The paper
Qi, H., Liu, C., Long, L., Ren, Y., Zhang, S., Chang, X., Qian, X., Jia, H., Zhao, J., Sun, J., Hou, X., Yuan, X., & Kang, C. (2016). Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy. ACS Nano. https://doi.org/10.1021/acsnano.5b06939