Cited by 181Nanoparticle-Based Drug DeliveryLipid Membrane Structure and BehaviorExtracellular vesicles in disease

Cell membrane-derived vesicles for delivery of therapeutic agents

Open access
Le, Quoc-Viet, Lee, Jaiwoo, Lee, Hobin, Shim, Gayong, Oh, Yu-Kyoung·2021·Acta Pharmaceutica Sinica B

Abstract

Cell membranes have recently emerged as a new source of materials for molecular delivery systems. Cell membranes have been extruded or sonicated to make nanoscale vesicles. Unlike synthetic lipid or polymeric nanoparticles, cell membrane-derived vesicles have a unique multicomponent feature, comprising lipids, proteins, and carbohydrates. Because cell membrane-derived vesicles contain the intrinsic functionalities and signaling networks of their parent cells, they can overcome various obstacles encountered in vivo. Moreover, the different natural combinations of membranes from various cell sources expand the range of cell membrane-derived vesicles, creating an entirely new category of drug-delivery systems. Cell membrane-derived vesicles can carry therapeutic agents within their interior or can coat the surfaces of drug-loaded core nanoparticles. Cell membranes typically come from single cell sources, including red blood cells, platelets, immune cells, stem cells, and cancer cells. However, recent studies have reported hybrid sources from two different types of cells. This review will summarize approaches for manufacturing cell membrane-derived vesicles and treatment applications of various types of cell membrane-derived drug-delivery systems, and discuss challenges and future directions.

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Crossref · 10.1016/j.apsb.2021.01.020

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  • Cell membranes as materials have unique characteristics from parent cells, including natural functionalities and information networks, that can overcome in vivo obstacles.

    “They have unique characteristics coming from their parent cells, including the natural functionalities and transmitting information networks that could conquer many obstacles confronted in vivo.”

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  1. [10]Sayed M.M.E. Takata H. Shimizu T. Kwaguchi Y. Lila A.S.A. Elsadek N.E. Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production J Control Release 323 2020 179 190 32278827

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Authors
Le, Q.-V., Lee, J., Lee, H., Shim, G., & Oh, Y.-K.
Affiliations
  • Seoul National University (KR)
  • Soongsil University (KR)
Corresponding author
  • Shim, Gayong
  • Oh, Yu-Kyoung
Venue
Acta Pharmaceutica Sinica B
Publisher
Elsevier BV
Published
2021-08
Volume
11
Issue
8
Pages
2096-2113
ISSN
2211-3835 (ISSN-L)
OpenAlex
W3129015041
Cited by
181
References
130
Citations by year
2026: 23 · 2025: 54 · 2024: 27 · 2023: 38 · 2022: 34 · 2021: 5
FWCI
1.80
Type
journal article
Language
en
Open access
Locations
  • Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Research Foundation of Korea
  • Ministry of Trade, Industry and Energy
  • Ministry of Food and Drug Safety (9991007273)
  • Ministry of Science, ICT and Future Planning
  • Ministry of Health and Welfare
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
drug delivery, extracellular vesicles, hybrid vesicles, erythrocyte membrane, platelet membrane, tumor cell membrane, nanoparticle coating, therapeutic agents

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