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Dendritic cell derived exosomes loaded neoantigens for personalized cancer immunotherapies

Li, Ji, Li, Jiajia, Peng, Yiwei, Du, Yitian, Yang, Zhenzhen, Qi, Xianrong·2023·Journal of Controlled Release
DOI 10.1016/j.jconrel.2022.11.053
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Abstract

Despite the promising potential of cancer vaccine, their efficacy has been limited in clinical trials and improved methods are urgently needed. Here we designed a nanovaccine platform that contains dendritic cell derived exosomes carriers and patient-specific neoantigens for individualized immunotherapies. The nanovaccine exhibited convenient cargo loading and prolonged cargo transportation to the lymph nodes, followed by eliciting potent antigen specific broad-spectrum T-cell and B-cell-mediated immune responses with great biosafety and biocompatibility. Strikingly, delivery of neoantigen-exosome nanovaccine significantly prohibited tumor growth, prolonged survival, delayed tumor occurrences with long-term memory, eliminated the lung metastasis in the therapeutic, prophylactic and metastatic B16F10 melanoma as well as therapeutic MC-38 models, respectively. Additionally, exosome-based nanovaccine demonstrated synergistic antitumor response superior to liposomal formulation due to presence of exosomal proteins. Collectively, our research indicated improved strategies for cell free vaccines and suggested exosome-based nanoplatform for cancer immunotherapy and personalized nanotechnology. These findings represent a powerful pathway to generate individualized nanovaccine rapidly for clinical application.

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Metadata

Authors
Li, J., Li, J., Peng, Y., Du, Y., Yang, Z., & Qi, X.
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2023-01
Volume
353
Pages
423-433
ISSN
0168-3659
DOI
10.1016/j.jconrel.2022.11.053
Cited by
201
References
10
Language
en
Licence
Funders
  • National Natural Science Foundation of China (81973258)
  • Natural Science Foundation of Beijing Municipality (7202092, L202044)

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