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Smart self-transforming nano-systems for overcoming biological barrier and enhancing tumor treatment efficacy

Tao, Jun, Ning, Weiqing, Lu, Wei, Wang, Rui, Zhou, Hui, Zhang, Hongru, Xu, Jiayi, Wang, Shouju, Teng, Zhaogang, Wang, Lianhui·2025·Journal of Controlled Release
DOI 10.1016/j.jconrel.2025.01.058
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Abstract

Nanomedicines need to overcome multiple biological barriers in the body to reach the target area. However, traditional nanomedicines with constant physicochemical properties are not sufficient to meet the diverse and sometimes conflicting requirements during in vivo transport, making it difficult to penetrate various biological barriers, resulting in suboptimal drug delivery efficiency. Smart self-transforming nano-systems (SSTNs), capable of altering their own physicochemical properties (including size, charge, hydrophobicity, stiffness, morphology, etc.) under different physiological conditions, hold the potential to break through multiple biological barriers, thereby improving drug delivery efficiency and the efficacy of cancer treatment. In this review, we first summarize the design strategies of five most popular SSTNs (such as size-, charge-, hydrophilicity-, stiffness-, and morphology-self-transforming nano-systems), and then delve into their biomedical applications in enhancing circulation time, tissue penetration, and cellular uptake. Finally, we discuss the opportunities and challenges that SSTNs face in the future for cancer treatment and diagnosis.

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Research works printed but not linked: 123

  1. Jaffray, 2023, Nat. Can., 4, 1228
  2. Huang, 2022, Angew. Chem. Int. Ed., 61
  3. Wang, 2024, Acta Pharm. Sin. B, 14, 905, 10.1016/j.apsb.2023.12.010 · DOI
  4. Murphy, 2023, Brit. J. Anaesth., 131, 989, 10.1016/j.bja.2023.07.027 · DOI
  5. Zhang, 2021, Small, 17, 2005113, 10.1002/smll.202005113 · DOI
  6. Wang, 2015, Adv. Mater., 27, 2627, 10.1002/adma.201405926 · DOI
  7. Yamaguchi, 2022, Nat. Rev. Clin. Oncol., 19, 287, 10.1038/s41571-022-00601-9 · DOI
  8. Zhong, 2023, Adv. Healthc. Mater., 12, 2202307, 10.1002/adhm.202202307 · DOI
  9. Qi, 2019, Front. Pharmacol., 10, 1451, 10.3389/fphar.2019.01451 · DOI
  10. Sanità, 2020, Front. Mol. Biosci., 7, 10.3389/fmolb.2020.587012 · DOI
  11. Yezhelyev, 2006, Lancet Oncol., 7, 970, 10.1016/S1470-2045(06)70793-8 · DOI
  12. Zhang, 2024, Theranostics, 14, 220, 10.7150/thno.87425 · DOI
  13. Dutt, 2023, J. Nanobiotechnol., 21, 148, 10.1186/s12951-023-01909-z · DOI
  14. Gyöngyösi, 2020, Cardiovasc. Res., 116, 970
  15. Huang, 2024, Sci. Adv., 10
  16. Wang, 2024, Signal Transduct. Target. Ther., 9, 200, 10.1038/s41392-024-01889-y · DOI
  17. Yang, 2024, Adv. Funct. Mater., 34, 2402194, 10.1002/adfm.202402194 · DOI
  18. Blanco, 2015, Nat. Biotechnol., 33, 941, 10.1038/nbt.3330 · DOI · Paper page
  19. Zhou, 2020, J. Mater. Chem. B, 8, 6765, 10.1039/D0TB00649A · DOI · Paper page
  20. Liao, 2021, Nanoscale, 13, 18912, 10.1039/D1NR05872J · DOI
  21. Mitchell, 2021, Nat. Rev. Drug Discov., 20, 101, 10.1038/s41573-020-0090-8 · DOI · Paper page
  22. Tenchov, 2021, ACS Nano, 15, 16982, 10.1021/acsnano.1c04996 · DOI · Paper page
  23. Liu, 2022, J. Nanobiotechnol., 20, 127, 10.1186/s12951-022-01343-7 · DOI · Paper page
  24. Herdiana, 2022, Heliyon, 8, 10.1016/j.heliyon.2021.e08674 · DOI · Paper page
  25. Senapati, 2018, Signal Transduct. Target. Ther., 3, 7, 10.1038/s41392-017-0004-3 · DOI · Paper page
  26. Sun, 2017, Adv. Mater., 29, 1606628, 10.1002/adma.201606628 · DOI
  27. Meel, 2019, Nat. Nanotechnol., 14, 1007, 10.1038/s41565-019-0567-y · DOI
  28. Björnmalm, 2017, ACS Nano, 11, 9594, 10.1021/acsnano.7b04855 · DOI
  29. Zhang, 2020, Nat. Nanotechnol., 15, 145, 10.1038/s41565-019-0626-4 · DOI
  30. Ruan, 2019, Nano Lett., 19, 8318, 10.1021/acs.nanolett.9b03968 · DOI
  31. Zhang, 2009, Nat. Genet., 41, 205, 10.1038/ng.310 · DOI
  32. Ding, 2019, Nano Today, 29, 10.1016/j.nantod.2019.100800 · DOI
  33. Hu, 2018, Biomaterials, 178, 546, 10.1016/j.biomaterials.2018.03.056 · DOI
  34. Xie, 2020, EBioMedicine, 56, 10.1016/j.ebiom.2020.102821 · DOI
  35. Wilhelm, 2016, Nat. Rev. Mater., 1, 16014, 10.1038/natrevmats.2016.14 · DOI · Paper page
  36. Chen, 2021, Appl. Phys. Rev., 8, 10.1007/978-981-16-3492-5 · DOI
  37. Sayah, 2024, Int. J. Pharm., 662
  38. Doshi, 2010, J. R. Soc. Interface, 7, S403, 10.1098/rsif.2010.0134.focus · DOI
  39. Doshi, 2010, J. Control. Release, 146, 196, 10.1016/j.jconrel.2010.04.007 · DOI
  40. Cong, 1958, ACS Nano, 2020, 14
  41. Ji, 2018, Angew. Chem. Int. Ed., 57, 11384, 10.1002/anie.201807602 · DOI
  42. Lei, 2017, ACS Nano, 11, 7201, 10.1021/acsnano.7b03088 · DOI
  43. Li, 2018, ACS Appl. Mater. Interfaces, 10, 29314, 10.1021/acsami.8b09330 · DOI
  44. Tan, 2023, Adv. Mater., 35, 2210766, 10.1002/adma.202210766 · DOI
  45. Wang, 2022, J. Control. Release, 348, 1004, 10.1016/j.jconrel.2022.06.046 · DOI
  46. Griset, 2009, J. Am. Chem. Soc., 131, 2469, 10.1021/ja807416t · DOI
  47. Zhong, 2019, ACS Appl. Mater. Interfaces, 11, 33697, 10.1021/acsami.9b12620 · DOI
  48. Cai, 2020, Angew. Chem. Int. Ed., 132, 14118, 10.1002/ange.202001107 · DOI
  49. Guo, 2018, ACS Appl. Mater. Interfaces, 10, 41167, 10.1021/acsami.8b16395 · DOI
  50. Liang, 2021, Angew. Chem. Int. Ed., 60, 11464, 10.1002/anie.202102180 · DOI
  51. Li, 2021, Chem. Eng. J., 421
  52. Tang, 2024, ACS Nano, 18, 13950, 10.1021/acsnano.4c04147 · DOI
  53. Sun, 2014, Adv. Mater., 26, 7615, 10.1002/adma.201401554 · DOI
  54. Liu, 2023, ACS Appl. Mater. Interfaces, 15, 26252, 10.1021/acsami.3c00870 · DOI
  55. He, 2022, ACS Nano, 16, 13919, 10.1021/acsnano.2c02965 · DOI
  56. Li, 2021, Adv. Sci., 8, 2002589, 10.1002/advs.202002589 · DOI
  57. Yu, 2014, Biomaterials, 35, 3467, 10.1016/j.biomaterials.2013.12.096 · DOI
  58. Liu, 2018, Nanoscale, 10, 13737, 10.1039/C8NR02971G · DOI
  59. Zhang, 2022, J. Nanobiotechnol., 20, 31, 10.1186/s12951-021-01221-8 · DOI
  60. Li, 2015, Adv. Funct. Mater., 25, 4101, 10.1002/adfm.201501248 · DOI
  61. Zhou, 2009, Adv. Funct. Mater., 19, 3580, 10.1002/adfm.200900825 · DOI
  62. Niu, 2021, Chem. Eng. J., 414
  63. Han, 2021, Adv. Healthc. Mater., 10, 2002143, 10.1002/adhm.202002143 · DOI
  64. Liu, 2020, Small, 16, 2002115, 10.1002/smll.202002115 · DOI
  65. Wang, 2015, Small, 11, 1801, 10.1002/smll.201403248 · DOI
  66. Zhou, 2019, Nature Nanotech., 14, 799, 10.1038/s41565-019-0485-z · DOI
  67. Li, 2019, Biomaterials, 217
  68. Mi, 2020, Theranostics, 10, 4557, 10.7150/thno.38069 · DOI
  69. Nguyen, 2024, Nature Nanotech.
  70. Peng, 2022, Theranostics, 12, 1756, 10.7150/thno.68756 · DOI
  71. Nel, 2009, Nat. Mater., 8, 543, 10.1038/nmat2442 · DOI · Paper page
  72. Liu, 2023, Adv. Mater., 35, 2211980, 10.1002/adma.202211980 · DOI
  73. Nie, 2018, Angew. Chem. Int. Ed., 2020, 59
  74. Sun, 2015, Angew. Chem. Int. Ed., 55, 1010, 10.1002/anie.201509507 · DOI
  75. Gong, 2019, J. Mater. Chem. B, 7, 651, 10.1039/C8TB02882F · DOI
  76. Yang, 2019, Adv. Funct. Mater., 29, 1900143, 10.1002/adfm.201900143 · DOI
  77. Yang, 2018, Nano Lett., 18, 7909, 10.1021/acs.nanolett.8b03828 · DOI
  78. Anselmo, 2017, Adv. Drug Deliv. Rev., 108, 51, 10.1016/j.addr.2016.01.007 · DOI
  79. Miao, 2023, Macromolecules, 56, 7663, 10.1021/acs.macromol.3c01283 · DOI
  80. Gurnani, 2022, Small, 18, 2203070, 10.1002/smll.202203070 · DOI
  81. Yu, 2018, Nat. Commun., 9, 2607, 10.1038/s41467-018-05061-3 · DOI
  82. Zhou, 2024, J. Mater. Chem. B, 12, 1748, 10.1039/D3TB02610H · DOI
  83. Sun, 2022, ACS Nano, 16, 9183, 10.1021/acsnano.2c01407 · DOI
  84. Teng, 2018, J. Am. Chem. Soc., 140, 1385, 10.1021/jacs.7b10694 · DOI
  85. Tao, 2023, Angew. Chem. Int. Ed., 62
  86. Toy, 2014, Nanomedicine, 9, 121, 10.2217/nnm.13.191 · DOI
  87. Lin, 2024, Adv. Funct. Mater., 2405051, 10.1002/adfm.202405051 · DOI
  88. Tong, 2024, Nat. Commun., 15, 10382, 10.1038/s41467-024-54854-2 · DOI
  89. Mathaes, 2014, Int. J. Pharm., 465, 159, 10.1016/j.ijpharm.2014.02.037 · DOI
  90. Li, 2015, Nanoscale, 7, 16631, 10.1039/C5NR02970H · DOI
  91. Cheng, 2022, Small, 18, 2200915, 10.1002/smll.202200915 · DOI
  92. Yu, 2023, Angew. Chem. Int. Ed., 62
  93. Li, 2019, Nano Lett., 19, 7965, 10.1021/acs.nanolett.9b03136 · DOI
  94. Li, 2023, Mater. Horiz., 10, 5298, 10.1039/D3MH00867C · DOI
  95. Lin, 2020, Acta Pharm. Sin. B, 10, 2348, 10.1016/j.apsb.2020.10.009 · DOI
  96. Chen, 2018, Sci. China Chem., 61, 1503, 10.1007/s11426-018-9397-5 · DOI
  97. Liu, 2022, ACS Nano, 16, 9240, 10.1021/acsnano.2c01669 · DOI
  98. Petrini, 2021, Int. J. Nanomedicine, 16, 4045, 10.2147/IJN.S305106 · DOI
  99. Jia, 2021, Adv. Funct. Mater., 31, 2009765, 10.1002/adfm.202009765 · DOI
  100. Guo, 2019, Chem. Sci., 10, 7878, 10.1039/C9SC01841G · DOI
  101. Qiao, 2020, J. Mater. Chem. B, 8, 3138, 10.1039/D0TB00298D · DOI
  102. Cheng, 2021, ACS Appl. Mater. Interfaces, 13, 29257, 10.1021/acsami.1c03196 · DOI
  103. Qu, 2023, Nano Res., 16, 13267, 10.1007/s12274-023-5912-7 · DOI
  104. Zeng, 2024, Adv. Funct. Mater., 2406122
  105. Geng, 2007, Nat. Nanotechnol., 2, 249, 10.1038/nnano.2007.70 · DOI · Paper page
  106. Chen, 2020, ACS Nano, 14, 3640, 10.1021/acsnano.0c00118 · DOI
  107. Alexandrakis, 2004, Nat. Med., 10, 203, 10.1038/nm981 · DOI
  108. Yu, 2020, ACS Cent. Sci., 6, 100, 10.1021/acscentsci.9b01139 · DOI
  109. Lin, 2021, Adv. Funct. Mater., 31, 2101278, 10.1002/adfm.202101278 · DOI
  110. Chen, 2024, J. Control. Release, 372, 386, 10.1016/j.jconrel.2024.06.053 · DOI
  111. Ni, 2022, Int. J. Nanomedicine, 17, 5883, 10.2147/IJN.S383517 · DOI
  112. Agarwal, 2013, PNAS, 110, 17247, 10.1073/pnas.1305000110 · DOI
  113. Dai, 2017, Chem. Soc. Rev., 46, 3830, 10.1039/C6CS00592F · DOI
  114. Wei, 2019, Nat. Commun., 10, 3646, 10.1038/s41467-019-11631-w · DOI
  115. Li, 2016, PNAS, 113, 4164, 10.1073/pnas.1522080113 · DOI
  116. Chen, 2020, Chem. Sci., 11, 2819, 10.1039/C9SC06260B · DOI
  117. Shen, 2023, ACS Appl. Mater. Interfaces, 15, 20697, 10.1021/acsami.3c01155 · DOI
  118. Liu, 2024, J. Colloid Interface Sci., 675, 1080, 10.1016/j.jcis.2024.07.113 · DOI
  119. Huang, 2024, Viewpoints, 5, 20240010
  120. Liu, 2024, Viewpoints, 5, 20240023
  121. Jia, 2019, ACS Nano, 13, 11781, 10.1021/acsnano.9b05749 · DOI
  122. Yang, 2024, Adv. Funct. Mater., 34, 2402194, 10.1002/adfm.202402194 · DOI
  123. Zhao, 2018, Adv. Mater., 30, 1804982, 10.1002/adma.201804982 · DOI

Cited by

Sorted by citations

Metadata

Authors
Tao, J., Ning, W., Lu, W., Wang, R., Zhou, H., Zhang, H., Xu, J., Wang, S., Teng, Z., & Wang, L.
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2025-04
Volume
380
Pages
85-107
ISSN
0168-3659
DOI
10.1016/j.jconrel.2025.01.058
Cited by
10
References
1
Language
en
Licence
Funders
  • National Natural Science Foundation of China (22305128)
  • Nanjing University of Posts and Telecommunications (NY222067, NY221131)

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