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Smart self-transforming nano-systems for overcoming biological barrier and enhancing tumor treatment efficacy

Tao, Jun, Ning, Weiqing, Lu, Wei, Wang, Rui, Zhou, Hui, Zhang, Hongru, Xu, Jiayi, Wang, Shouju, Teng, Zhaogang, Wang, Lianhui·2025·Journal of Controlled Release
DOI 10.1016/j.jconrel.2025.01.058
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Abstract

Nanomedicines need to overcome multiple biological barriers in the body to reach the target area. However, traditional nanomedicines with constant physicochemical properties are not sufficient to meet the diverse and sometimes conflicting requirements during in vivo transport, making it difficult to penetrate various biological barriers, resulting in suboptimal drug delivery efficiency. Smart self-transforming nano-systems (SSTNs), capable of altering their own physicochemical properties (including size, charge, hydrophobicity, stiffness, morphology, etc.) under different physiological conditions, hold the potential to break through multiple biological barriers, thereby improving drug delivery efficiency and the efficacy of cancer treatment. In this review, we first summarize the design strategies of five most popular SSTNs (such as size-, charge-, hydrophilicity-, stiffness-, and morphology-self-transforming nano-systems), and then delve into their biomedical applications in enhancing circulation time, tissue penetration, and cellular uptake. Finally, we discuss the opportunities and challenges that SSTNs face in the future for cancer treatment and diagnosis.

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Metadata

Authors
Tao, J., Ning, W., Lu, W., Wang, R., Zhou, H., Zhang, H., Xu, J., Wang, S., Teng, Z., & Wang, L.
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2025-04
Volume
380
Pages
85-107
ISSN
0168-3659
DOI
10.1016/j.jconrel.2025.01.058
Cited by
10
References
1
Language
en
Licence
Funders
  • National Natural Science Foundation of China (22305128)
  • Nanjing University of Posts and Telecommunications (NY222067, NY221131)

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