The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Role of antioxidants in the skin: Anti-aging effects
Abstract
Intracellular and extracellular oxidative stress initiated by reactive oxygen species (ROS) advance skin aging, which is characterized by wrinkles and atypical pigmentation. Because UV enhances ROS generation in cells, skin aging is usually discussed in relation to UV exposure. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. In this review, the mechanisms of ROS generation and ROS elimination in the body are summarized. The effects of ROS generated in the skin and the roles of ROS in altering the skin are also discussed. In addition, the effects of representative antioxidants on the skin are summarized with a focus on skin aging.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This article lists some experimental cases of food-derived polyphenol extracts to alleviate skin aging (Table 2), but most of the anti-aging effect of polyphenols has been verified in vitro through topical administration on target skin cells. Nonetheless, the clinical application of polyphenols in dermatology is still in its infancy, and there are relatively few reports on the cytotoxicity of poly”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [114]
Citations
Cites
Diversity of structures and properties among catalases
Chelikani, P., Fita, I., & Loewen, P. C. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3206-5 · Cited by 1,760
Role of nitric oxide synthesis in macrophage antimicrobial activity
Nathan, C. F., & Hibbs, J. B. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90079-g · Cited by 1,523
Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,473
Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway
Zhang, D. D. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600971974 · Cited by 1,105
Mechanism of Human SIRT1 Activation by Resveratrol
Borra, M. T., Smith, B. C., & Denu, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501250200 · Cited by 1,065
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
Denu, J. M., & Tanner, K. G. (1998) · Biochemistry · doi:10.1021/bi973035t · Cited by 945
BABIOR, B. M., Lambeth, J. D., & Nauseef, W. M. (2002) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2642 · Cited by 911
Oxygen free radicals and metallothionein
Sato, M., & Bremner, I. (1993) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(93)90029-t · Cited by 855
Mustacich, D. J., & Powis, G. (2000) · Biochemical Journal · doi:10.1042/bj3460001 · Cited by 838
Cited by
Sorted by citations
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Molecular Mechanisms of Dermal Aging and Antiaging Approaches
Shin, J.-W., Kwon, S.-H., Choi, J.-Y., Na, J.-I., Huh, C.-H., Choi, H.-R., & Park, K.-C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092126 · Cited by 875
Fighting against Skin Aging: The Way from Bench to Bedside
Zhang, S., & Duan, E. (2018) · Cell Transplantation · doi:10.1177/0963689717725755 · Cited by 739
Medicinal prospects of antioxidants: A review
Neha, K., Haider, M. R., Pathak, A., & Yar, M. S. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.06.010 · Cited by 748
Exploring the potential of using algae in cosmetics
Wang, H., Chen, C.-C., Huynh, P., & Chang, J. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.12.001 · Cited by 509
Metadata
- Authors
- Masaki, H.
- Affiliations
- Cosmos Technical Center Co., Ltd. (Japan) (JP)
- Corresponding author
- Masaki, Hitoshi
- ORCID
- Masaki, Hitoshi
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 58
- Issue
- 2
- Pages
- 85-90
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W2078923345
- Cited by
- 788
- References
- 83
- Citations by year
- 2026: 48 · 2025: 71 · 2024: 77 · 2023: 61 · 2022: 87 · 2021: 73 · 2020: 56 · 2019: 58 · 2018: 53 · 2017: 36 · 2016: 37 · 2015: 36 · 2014: 37 · 2013: 17 · 2012: 18
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- antioxidants, skin aging, oxidative stress, reactive oxygen species, photoaging, ultraviolet radiation, wrinkles, hyperpigmentation, reactive oxygen species scavenging
- MeSH terms
- Aging, Antioxidants, Ascorbic Acid, Carotenoids, Flavonoids, Humans, Inflammation, Models, Biological, Phenols, Sebaceous Glands, Skin, Ultraviolet Rays, Vitamin E, Skin Aging, Reactive Oxygen Species, Oxidative Stress, Polyphenols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
