Solar UV irradiation and dermal photoaging
Abstract
The skin is increasingly exposed to ambient UV-irradiation thus increasing risks for photooxidative damage with long-term detrimental effects like photoaging, characterized by wrinkles, loss of skin tone and resilience. Photoaged skin displays alterations in the cellular component and extracellular matrix with accumulation of disorganized elastin and its microfibrillar component fibrillin in the deep dermis and a severe loss of interstitial collagens, the major structural proteins of the dermal connective tissue. The unifying pathogenic agents for these changes are UV-generated reactive oxygen species (ROS) which deplete and damage non-enzymatic and enzymatic antioxidant defense systems of the skin. As well as causing permanent genetic changes, ROS activate cytoplasmic signal transduction pathways in resident fibroblasts that are related to growth, differentiation, senescence and connective tissue degradation. This review focuses on the role of UV-induced ROS in the photodamage of the skin resulting in clinical and biochemical characteristics of photoaging. In addition, the relationship of photoaging to intrinsic aging of the skin will be briefly discussed. A decrease in the overall ROS load by efficient sunscreens or other protective agents may represent promising strategies to prevent or at least minimize ROS-induced photoaging.
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If used properly, regular sunscreen use can prevent or delay photoaging of the skin.
“and prevent or delay photoaging of the skin.8–10”
From Patterns of sunscreen use on the face and other exposed skin among US adults (2015) · cites this paper as [9]
UVB penetrates into epidermal cells, can damage DNA and activate a cascade leading to generation of ROS and increased photo-aging.
“UVB (280-320 nm), while representing only 2-5% of the sun's emissions, penetrates into epidermal cells, can damage DNA and activate a cascade of events leading to the generation of ROS and increased photo-aging [2,13,23,24].”
The severity of extrinsic ageing depends on skin type, with features more prominent in type I or II skin and less noticeable in type III or higher skin.
“The severity of extrinsic ageing depends on skin type, with the features being more prominent in type I or II skin and less noticeable in type III or higher skin [5].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [5]
The rate of UVR-induced skin ageing depends on the balance between the frequency, intensity and duration of exposure and the natural protection by skin pigmentation.
“The rate of UVR-induced skin ageing depends on the balance between the frequency, intensity and duration of exposure and the natural protection by skin pigmentation [5].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [5]
Both UVA and UVB contribute to UVR-induced ageing; UVA causes disproportionately more damage due to its ability to penetrate deeper into the dermis.
“Both UVA and UVB have been shown to contribute to UVR-induced ageing; however, due to its ability to penetrate deeper into the dermis, UVA has been shown to cause disproportionately more damage [5].”
From Oxidative Stress and Ageing: The Influence of Environmental Pollution, Sunlight and Diet on Skin (2017) · cites this paper as [5]
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- Authors
- Wlaschek, M., Tantcheva-Poór, I., Naderi, L., Ma, W., Schneider, L. A., Razi-Wolf, Z., Schüller, J., & Scharffetter-Kochanek, K.
- Affiliations
- University of Cologne (DE)
- Venue
- Journal of Photochemistry and Photobiology B Biology
- Publisher
- Elsevier BV
- Published
- 2001-10
- Volume
- 63
- Issue
- 1-3
- Pages
- 41-51
- ISSN
- 1011-1344 (ISSN-L)
- OpenAlex
- W2072035390
- Cited by
- 509
- References
- 53
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 18 · 2023: 22 · 2022: 22 · 2021: 42 · 2020: 35 · 2019: 30 · 2018: 23 · 2017: 32 · 2016: 29 · 2015: 28 · 2014: 20 · 2013: 26 · 2012: 13
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Photochemistry and Photobiology B Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- reactive oxygen species, photooxidative damage, dermal fibroblasts, extracellular matrix, collagen loss, elastin, fibrillin, antioxidant defense, intrinsic skin aging, signal transduction
- MeSH terms
- Aging, Animals, Humans, Models, Biological, Ultraviolet Rays, Skin Aging, Reactive Oxygen Species, Solar Activity
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