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Role of antioxidants in the skin: Anti-aging effects
Abstract
Intracellular and extracellular oxidative stress initiated by reactive oxygen species (ROS) advance skin aging, which is characterized by wrinkles and atypical pigmentation. Because UV enhances ROS generation in cells, skin aging is usually discussed in relation to UV exposure. The use of antioxidants is an effective approach to prevent symptoms related to photo-induced aging of the skin. In this review, the mechanisms of ROS generation and ROS elimination in the body are summarized. The effects of ROS generated in the skin and the roles of ROS in altering the skin are also discussed. In addition, the effects of representative antioxidants on the skin are summarized with a focus on skin aging.
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“This article lists some experimental cases of food-derived polyphenol extracts to alleviate skin aging (Table 2), but most of the anti-aging effect of polyphenols has been verified in vitro through topical administration on target skin cells. Nonetheless, the clinical application of polyphenols in dermatology is still in its infancy, and there are relatively few reports on the cytotoxicity of poly”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [114]
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Hallmarks of Skin Aging: Update
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Metadata
- Authors
- Masaki, H.
- Affiliations
- Cosmos Technical Center Co., Ltd. (Japan) (JP)
- Corresponding author
- Masaki, Hitoshi
- ORCID
- Masaki, Hitoshi
- Venue
- Journal of Dermatological Science
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 58
- Issue
- 2
- Pages
- 85-90
- ISSN
- 0923-1811 (ISSN-L)
- OpenAlex
- W2078923345
- Cited by
- 788
- References
- 83
- Citations by year
- 2026: 48 · 2025: 71 · 2024: 77 · 2023: 61 · 2022: 87 · 2021: 73 · 2020: 56 · 2019: 58 · 2018: 53 · 2017: 36 · 2016: 37 · 2015: 36 · 2014: 37 · 2013: 17 · 2012: 18
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Dermatological Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- antioxidants, skin aging, oxidative stress, reactive oxygen species, photoaging, ultraviolet radiation, wrinkles, hyperpigmentation, reactive oxygen species scavenging
- MeSH terms
- Aging, Antioxidants, Ascorbic Acid, Carotenoids, Flavonoids, Humans, Inflammation, Models, Biological, Phenols, Sebaceous Glands, Skin, Ultraviolet Rays, Vitamin E, Skin Aging, Reactive Oxygen Species, Oxidative Stress, Polyphenols
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