Characterization of the antinociceptive and anti-inflammatory activities from Cocos nucifera L. (Palmae)
Open accessAbstract
Aim of the study Cocos nucifera cultivated in Brazil is known as "coco-da-Bahia" or "coqueiro-da-India". The tea from the husk fiber is widely used to several inflammatory disorders. Crude extract and fractions obtained from Cocos nucifera "common variety" were evaluated to test the anti-inflammatory and antinociceptive activities.Materials and methods Crude extract (CE, 50, 100, and 150 mg/kg), fraction 1 (F1, molecular weight lesser than 1 kDa, 1, 10, and 50mg/kg), fraction 2 (F2, molecular weight higher than 1 kDa, 1, 10, and 50mg/kg), and the references drugs morphine (5mg/kg), acetilsalicilic acid (200mg/kg), prometazine (30 mg/kg), and metisergide (5mg/kg) were evaluated on models of analgesia and inflammation.Results CE, F1, and F2 significantly develop peripheral and central antinociceptive activity but with less effect on supra-spinal regions of the brain. Administration of the opioid antagonist, naloxone (5mg/kg) inhibited the antinociceptive effect indicating that Cocos nucifera crude extract and fractions may be acting in opioid receptors. CE and F1 also inhibited rat paw edema induced by histamine, and serotonin.Conclusions results demonstrated that Cocos nucifera and its fractions have antinociceptive and anti-inflammatory activities which confirm the popular use of this plant in several inflammatory disorders.
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The crude husk fiber extract significantly reduced histamine (at 150 mg/kg) and serotonin-induced rat paw edema (at 100 and 150 mg/kg).
“The crude extract significantly (P<0.05) reduced histamine (at 150 mg/kg) and serotonin-induced rat paw edema (at 100 and 150 mg/kg).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [44]
Various extracts, fractions, and isolated compounds from different parts of the coconut fruit show activities including antihypertensive; analgesia; vasodilation; protection of kidney, heart, and liver functions; protection against ulcers; and anti-inflammatory, anti-oxidant, anti-osteoporosis, antidiabetes, antineoplastic, bactericidal, antihelminthic, antimalarial, leishmanicidal, antifungal, и
“Various extracts, fractions, and isolated compounds from different parts of the coconut fruit were tested, showing different activities, including antihypertensive; analgesia; vasodilation; protection of kidney, heart, and liver functions; protection against ulcers; and anti-inflammatory, anti-oxidant, anti-osteoporosis, antidiabetes, antineoplastic, bactericidal, antihelminthic, antimalarial, le”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [44]
Crude husk-fiber extract and two aqueous extract fractions (F1 and F2) induced peripheral and central antinociceptive activity in mice.
“All three extracts induced peripheral and central antinociceptive activity.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [44]
Naloxone inhibited the antinociceptive effect of the crude extract, F1, and F2, indicating a probable action on opioid receptors.
“The mechanism of action of the extracts were also evaluated using the opioid antagonist naloxone (5 mg/kg), which inhibited the antinociceptive effect of the crude extract, F1, and F2, indicating a probable action on opioid receptors.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [44]
F2 did not inhibit edema induced by any pro-inflammatory agent.
“However, F2 did not inhibit the edema induced by any pro-inflammatory agent.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [44]
Oral treatment of mice over 5 days with a single dose (500 mg/kg) of crude extract, F1, and F2 of C. nucifera mesocarp caused no behavioral changes and no injury or bleeding stomachs.
“The oral treatment of mice over 5 days with a single dose (500 mg/kg) caused no behavioral changes. No injury or bleeding stomachs were observed.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [44]
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Cites
A new approach to practical acute toxicity testing
Lorke, D. E. (1983) · Archives of Toxicology · doi:10.1007/bf01234480 · Cited by 3,038 · see citing works
Release of prostaglandins E and F in an algogenic reaction and its inhibition
Deraedt, R., Jouquey, S., Delevallée, F., et al. (1980) · European Journal of Pharmacology · doi:10.1016/0014-2999(80)90377-5 · Cited by 744 · see citing works
Biological properties of carrageenan
Rosa, M. D. (1972) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1972.tb08940.x · Cited by 461 · see citing works
The formalin test in mice: effect of formalin concentration
Rosland, J. H., Tjølsen, A., Maehle, B. O., & Hole, K. (1990) · Pain · doi:10.1016/0304-3959(90)91167-h · Cited by 399 · see citing works
Verpoorte, R. (1998) · Drug Discovery Today · doi:10.1016/s1359-6446(97)01167-7 · Cited by 396 · see citing works
Esquenazi, D., Wigg, M. D., Miranda, M. M. F. S., Rodrigues, H. M., Tostes, J. B. F., Rozental, S., da Silva, A. J. R., & Alviano, C. S. (2002) · Research in Microbiology · doi:10.1016/s0923-2508(02)01377-3 · Cited by 291 · see citing works
Self-citationAntinociceptive activity of Amazonian Copaiba oils
Gomes, N. M., Rezende, C. M., Fontes, S. P., et al. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.08.018 · Cited by 191 · see citing works
Alviano, W. S., Alviano, D. S., Diniz, C. G., Antoniolli, Â. R., Alviano, C. S., Farias, L. M., de Carvalho, M. A. R., de Souza, M. M. G., & Bolognese, A. M. (2008) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2007.12.001 · Cited by 153 · see citing works
Self-citationMendonça-Filho, R. R., Rodrigues, I. A., Alviano, D. S., Santos, A. L. S., Soares, R. M. A., Alviano, C. S., Lopes, A. H. C. S., & do Socorro S. Rosa, M. (2004) · Research in Microbiology · doi:10.1016/j.resmic.2003.12.001 · Cited by 115 · see citing works
Self-citationA new method for measuring variations of rat paw volume
Ferreira, S. H. (1979) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1979.tb13616.x · Cited by 109 · see citing works
Esquenazi, D., Alviano, C. S., de Souza, W., et al. (2004) · Research in Microbiology · doi:10.1016/j.resmic.2003.12.002 · Cited by 71 · see citing works
Self-citationAlviano, D. S., Rodrigues, K. F., Leitão, S. G., Rodrigues, M. L., Matheus, M. E., Fernandes, P. D., Antoniolli, Â. R., & Alviano, C. S. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.03.013 · Cited by 60 · see citing works
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Matheus, M. E., Berrondo, L. F., Vieitas, E. C., et al. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.06.033 · Cited by 56 · see citing works
Self-citationThe effect of a catechin‐rich extract of Cocos nucifera on lymphocytes proliferation
Kirszberg, C., Esquenazi, D., Alviano, C. S., & Rumjanek, V. M. (2003) · Phytotherapy Research · doi:10.1002/ptr.1297 · Cited by 45 · see citing works
Self-citationThe husk fiber of Cocos nucifera L. (Palmae) is a source of anti-neoplastic activity
Koschek, P. R., Alviano, D. S., Alviano, C. S., & Gattass, C. R. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2006005000153 · Cited by 36 · see citing works
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Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review
Lima, E. B. C., Sousa, C. N. S., Meneses, L. N., Ximenes, N. C., Santos Júnior, M. A., Vasconcelos, G. S., Lima, N. B. C., Patrocínio, M. C. A., Macedo, D., & Vasconcelos, S. M. M. (2015) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20154773 · Cited by 295 · see citing works
Anti-inflammatory, antioxidant, and antimicrobial activities of Cocos nucifera var. typica
Silva, R. R., e Silva, D. O., Fontes, H. R., Alviano, C. S., Fernandes, P. D., & Alviano, D. S. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-107 · Cited by 66 · see citing works
Self-citationAkinpelu, D. A., Alayande, K. A., Aiyegoro, O. A., Akinpelu, O. F., & Okoh, A. I. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0634-3 · Cited by 35 · see citing works
- Authors
- Rinaldi, S., Silva, D. O., Bello, F., Alviano, C. S., Alviano, D. S., Matheus, M. E., & Fernandes, P. D.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 122
- Issue
- 3
- Pages
- 541-546
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W2073059197
- Cited by
- 56
- References
- 15
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Cocos nucifera, coconut husk fiber, antinociceptive activity, anti-inflammatory activity, opioid receptors, naloxone, paw edema, histamine-induced edema, serotonin, crude extract, molecular weight fractions, analgesia
- MeSH terms
- Analgesics, Animals, Anti-Inflammatory Agents, Cocos, Edema, Fruit, Male, Phytotherapy, Naloxone, Narcotic Antagonists, Pain, Plant Extracts, Acetic Acid, Mice
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