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Anethum graveolens (Dill)—A Medicinal Herb Induces Apoptosis and Cell Cycle Arrest in HepG2 Cell Line

Mohammed, Furkhan Ahmed, Elkady, Ayman I., Syed, Fareeduddin Quadri, Mirza, Muqtadir Baig, Hakeem, Khalid Rehman, Alkarim, Saleh·2018·Journal of Ethnopharmacology
DOI 10.1016/j.jep.2018.03.008
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Abstract

Ethnopharmacological relevance The medicinal herb, Anethum graveolens L. (dill) is one of the potent culinary herbs used as an alternative form of medicine worldwide. The unguent topical Oil from the aerial parts of A. graveolens was found to be effective in the management of uterus cancer in ethnomedicine has been reported. Background The incidence and mortality rates of Hepatocellular carcinoma (HCC) are steadily rising worldwide, especially, in underdeveloped and developing countries. Moreover, HCC develops rapidly in patients with chronic cirrhosis or hepatitis, where the solid tumours/malignancies coexist with the inflammation. Recent studies have shown that the medicinal herb, Anethum graveolens, holds anticancer potential, which could be a promising approach for the treatment of various tumours. Aim In the current study, we have analysed the antiproliferative effect of ethyl acetate fraction of Dill Seeds (EAFD) on HepG2 cell line. Methods Cell viability and proliferation were observed by MTT assay; Morphological changes were studied using fluorescent stains like Hoechst 33342, acridine orange/ethidium bromide and JC-1 dye. Further, the pro-apoptotic activity was demonstrated through Annexin-V-FITC/ PI assay and cell cycle analysis. Different concentrations (0.1, 0.2, 0.4, 0.6, 0.8 mg/ml) of EAFD were studied. Results EAFD markedly suppressed the proliferation of HepG2 cells in a dose and time-dependent manner. The phase contrast and fluorescence microscopy revealed th…

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Metadata

Authors
Mohammed, F. A., Elkady, A. I., Syed, F. Q., Mirza, M. B., Hakeem, K. R., & Alkarim, S.
Venue
Journal of Ethnopharmacology
Publisher
Elsevier BV
Published
2018-06
Volume
219
Pages
15-22
ISSN
0378-8741
DOI
10.1016/j.jep.2018.03.008
Cited by
39
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
King Abdulaziz City for Science and Technology (AT-32–66)

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