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Cited by 135Redox biology and oxidative stressAntioxidant Activity and Oxidative StressCancer and biochemical research

Dual effect of oxidative stress on leukemia cancer induction and treatment

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Udensi, Udensi K, Tchounwou, Paul B·2014·Journal of Experimental & Clinical Cancer Research
DOI 10.1186/s13046-014-0106-5PMC PMC4320640
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Abstract

Oxidative stress (OS) has been characterized by an imbalance between the production of reactive oxygen species (ROS) and a biological system's ability to repair oxidative damage or to neutralize the reactive intermediates including peroxides and free radicals. High ROS production has been associated with significant decrease in antioxidant defense mechanisms leading to protein, lipid and DNA damage and subsequent disruption of cellular functions. In humans, OS has been reported to play a role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Lou Gehrig's disease, multiple sclerosis and Parkinson's disease, as well as atherosclerosis, autism, cancer, heart failure, and myocardial infarction. Although OS has been linked to the etiology and development of chronic diseases, many chemotherapeutic drugs have been shown to exert their biologic activity through induction of OS in affected cells. This review highlights the controversial role of OS in the development and progression of leukemia cancer and the therapeutic application of increased OS and antioxidant approaches to the treatment of leukemia patients.

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  • Stress and emotional imbalance are among the most important factors leading to the worsening and recurrence of leukemia symptoms.

    “Recent studies have shown that stress and emotional imbalance are among the most important factors leading to the worsening and recurrence of leukemia symptoms (7, 8).”

    From The Effectiveness of Dialectical Behavior Therapy on Psychological Resilience and Existential Anxiety in Adolescents with Leukemia (2021) · cites this paper as [8]

    The Introduction discusses oxidative stress as an imbalance involving reactive oxygen species, and the 'Leukemia and reactive oxygen species' section discusses cellular stress signaling. Neither addresses emotional imbalance or says psychological stress worsens or causes recurrence of leukemia symptoms. Searches for emotional imbalance, psychological stress, recurrence, and relapse found no passage supporting the attributed claim. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Udensi, U. K., & Tchounwou, P. B.
Affiliations
Jackson State University (US)
Corresponding author
Tchounwou, Paul B
ORCID
Tchounwou, Paul B
Venue
Journal of Experimental & Clinical Cancer Research
Publisher
Springer Science and Business Media LLC
Published
2014-12
Volume
33
Issue
1
Pages
106-106
ISSN
  • 0392-9078 (ISSN-L)
  • 1756-9966
DOI
10.1186/s13046-014-0106-5
PMC
PMC4320640
OpenAlex
W2132847537
Cited by
135
References
3
Citations by year
2026: 2 · 2025: 7 · 2024: 14 · 2023: 17 · 2022: 6 · 2021: 20 · 2020: 16 · 2019: 18 · 2018: 11 · 2017: 9 · 2016: 7 · 2015: 8
FWCI
0.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Experimental & Clinical Cancer Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute on Minority Health and Health Disparities (G12MD007581)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords
oxidative stress, leukemia, reactive oxygen species, antioxidant defense, cancer induction, chemotherapeutic drugs, DNA damage, free radicals
MeSH terms
Animals, Antineoplastic Agents, Antioxidants, Cell Transformation, Neoplastic, Humans, Leukemia, Signal Transduction, Reactive Oxygen Species, Oxidative Stress

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