A 20-hydroxyecdysone-enriched fraction from Pfaffia glomerata (Spreng.) pedersen roots alleviates stress, anxiety, and depression in mice
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE Pfaffia glomerata roots are widely used in Brazil to treat various pathological conditions, particularly psychological disorders. 20-hydroxyecdysone, a phytosteroid present in the plant, can promote greater body resistance against exogenous and endogenous stressors. The objective of this study was to evaluate the possible neuroprotective effect of a 20-hydroxyecdysone-enriched fraction (20E-EF), obtained from P. glomerata roots, in an acute murine stress model. MATERIAL AND METHODS The 20E-EF was obtained by partitioning the methanol extract from P. glomerata roots with dichloromethane. Mice were treated by gavage with three doses of 20E-EF (3, 10, and 30 mg/kg) and parameters of stress, anxiety, and depression were evaluated. Biomarkers of oxidative stress (enzymes, antioxidant profile, and oxidized molecules) were evaluated in the cortex, striatum (basal ganglia), and hippocampus of animals treated with 30 mg/kg of 20E-EF. RESULTS Mass spectrometry revealed that 20E was the main compound in the dichloromethane fraction. At a dose of 30 mg/kg, 20E-EF reduced stress, anxiety, and depression, while stimulating antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase), promoting antioxidant activity (antioxidant capacity, sulfhydryl groups, and reduced glutathione), and reducing oxidative markers (lipid peroxidation). In addition, 20E increased the concentration of NO in the striatum, possibly improving memory function and antioxidant activity. CONCLUSION A 30 mg/kg dose of 20E-EF was able to reduce stress, anxiety, and depression, in addition to maintaining antioxidant defenses of the cortex and striatum. These findings open new perspectives for understanding the therapeutic properties of P. glomerata and the underlying mechanism(s).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Stress, anxiety, and depression were reduced in mice by a 20E-enriched fraction of Pfafia glomerulata roots.
“Stress, anxiety, and depression were reduced in mice by a 20E-enriched fraction of Pfafia glomerulata roots [53].”
From Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? (2025) · cites this paper as [53]
Anti-oxidant enzymes were activated, and oxidative markers were reduced.
“The anti-oxidant enzymes were activated, and the oxidative markers were reduced.”
From Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? (2025) · cites this paper as [53]
The concentration of NO increased in the striatum.
“The concentration of NO increased in the striatum, which may improve memory function and anti-oxidant activity.”
From Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? (2025) · cites this paper as [53]
Ecdysterone does not appear to possess any severe side effects.
“Furthermore, ecdysterone does not appear to possess any severe side effects [19,47,49,50,51,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101].”
From Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition (2024) · cites this paper as [50]
Ecdysteroids have purported adaptogenic and non-androgenic anabolic properties in mammals.
“One of the most interesting properties of ecdysteroids in mammals is their purported adaptogenic and non-androgenic anabolic properties [24].”
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762 · see citing works
Dose translation from animal to human studies revisited.
Reagan‐Shaw, S., Nihal, M., & Ahmad, N. (2008) · The FASEB Journal · doi:10.1096/fj.07-9574lsf · Cited by 6,524 · see citing works
A Rapid, Simple Spectrophotometric Method for Simultaneous Detection of Nitrate and Nitrite
Miranda, K. M., Espey, M. G., & Wink, D. A. (2001) · Nitric Oxide · doi:10.1006/niox.2000.0319 · Cited by 3,858 · see citing works
Biochemistry of oxidative stress
Halliwell, B. B. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351147 · Cited by 1,546 · see citing works
Frontal cortex and reward-guided learning and decision-making
Rushworth, M. F. S., Noonan, M. P., Boorman, E. D., Walton, M. E., & Behrens, T. E. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.014 · Cited by 1,111 · see citing works
Oxidative stress in brain agingImplications for therapeutics of neurodegenerative diseases
Floyd, R. A., & Hensley, K. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00019-2 · Cited by 830 · see citing works
Aksenov, M. Y., & Markesbery, W. R. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01636-6 · Cited by 661 · see citing works
GABA and GABA Receptors in the Central Nervous System and Other Organs
Watanabe, M., Maemura, K., Kanbara, K., Tamayama, T., & Hayasaki, H. (2002) · International review of cytology · doi:10.1016/s0074-7696(02)13011-7 · Cited by 631 · see citing works
Neurobiology and consequences of social isolation stress in animal model—A comprehensive review
Mumtaz, F., Khan, M. I., Zubair, M., & Dehpour, A. R. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.086 · Cited by 369 · see citing works
Zanelati, T., Biojone, C., Moreira, F., Guimarães, F., & Joca, S. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00521.x · Cited by 366 · see citing works
Flavonoids from Hypericum perforatum Show Antidepressant Activity in the Forced Swimming Test
Butterweck, V., Jürgenliemk, G., Nahrstedt, A., & Winterhoff, H. (2000) · Planta Medica · doi:10.1055/s-2000-11119 · Cited by 363 · see citing works
Plants and the central nervous system
Carlini, E. A. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00112-6 · Cited by 357 · see citing works
Campos, A. C., Ortega, Z., Palazuelos, J., Fogaça, M. V., Aguiar, D. C., Díaz-Alonso, J., Ortega-Gutiérrez, S., Vázquez-Villa, H., Moreira, F. A., Guzmán, M., et al. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001502 · Cited by 313 · see citing works
Maes, M. H. J., Kubera, M., Obuchowiczwa, E., Goehler, L. E., & Brzeszcz, J. (2011) · PubMed · Cited by 303 · see citing works
Panossian, A. G., & Wikman, G. (2010) · Pharmaceuticals · doi:10.3390/ph3010188 · Cited by 303 · see citing works
Where in the Brain Is Depression?
Pandya, M. A., Altinay, M. I., Malone, D. A., & Anand, A. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0322-7 · Cited by 302 · see citing works
New Experiences Enhance Coordinated Neural Activity in the Hippocampus
Cheng, S., & Frank, L. M. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.035 · Cited by 286 · see citing works
Glutamate- and GABA-based CNS therapeutics
Foster, A. C., & Kemp, J. A. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.11.005 · Cited by 214 · see citing works
Bardeen, J. R., & Fergus, T. A. (2016) · Journal of Contextual Behavioral Science · doi:10.1016/j.jcbs.2016.02.002 · Cited by 213 · see citing works
Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders
Macpherson, T., & Hikida, T. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12830 · Cited by 131 · see citing works
Why is nitric oxide important for our brain?
Dzoljic, E. D. (2015) · Functional Neurology · doi:10.11138/fneur/2015.30.3.159 · Cited by 112 · see citing works
Uddin, M. S., Mamun, A. A., Kabir, M. T., Jakaria, M., Mathew, B., Barreto, G. E., & Ashraf, G. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1420-2 · Cited by 110 · see citing works
Brazilian plants as possible adaptogens: An ethnopharmacological survey of books edited in Brazil
Mendes, F. R., & Carlini, E. A. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.08.024 · Cited by 107 · see citing works
Franco, R. R., Alves, V. H. M., Zabisky, L. F. R., Justino, A. B., Martins, M. M., Saraiva, A. L., Goulart, L. R., & Espíndola, F. S. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109798 · Cited by 69 · see citing works
Self-citationHu, J., Luo, C. X., Chu, W. H., Shan, Y. A., Qian, Z.-M., Zhu, G., Yu, Y. B., & Feng, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050764 · Cited by 67 · see citing works
Takatsu-Coleman, A. L., Patti, C. L., Zanin, K. A., Zager, A., Carvalho, R. C., Borçoi, A. R., Ceccon, L. M. B., Berro, L. F., Tufik, S., Andersen, M. L., et al. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120050 · Cited by 66 · see citing works
Justino, A. B., Pereira, M. N., Peixoto, L. G., Vilela, D. D., Caixeta, D. C., de Souza, A. V., Teixeira, R. R., Silva, H. C. G., de Moura, F. B. R., Moraes, I. B., et al. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b01355 · Cited by 65 · see citing works
Self-citationFranco, R. R., Zabisky, L. F. R., Júnior, J. P. D. L., Alves, V. H. M., Justino, A. B., Saraiva, A. L., Goulart, L. R., & Espíndola, F. S. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113132 · Cited by 64 · see citing works
Self-citationHunyadi, A., Herke, I., Lengyel, K., Báthori, M., Kele, Z., Simon, A., Tóth, G., & Szendrei, K. (2016) · Scientific Reports · doi:10.1038/srep37322 · Cited by 59 · see citing works
Teixeira, R. R., de Souza, A. V., Peixoto, L. G., Machado, H. L., Caixeta, D. C., Vilela, D. D., Baptista, N. B., Franci, C. R., & Espíndola, F. S. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.010 · Cited by 58 · see citing works
Kaur, P., Robin, R., Makanjuola, V. O., Arora, R., Singh, B., & Arora, S. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.09.081 · Cited by 54 · see citing works
Psychopharmacological screening of Pfaffia glomerata Spreng. (Amarathanceae) in rodents
de-Paris, F., Neves, G. A., Salgueiro, J. B., Quevedo, J., Izquierdo, I., & Rates, S. M. K. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00329-9 · Cited by 46 · see citing works
Xia, X., Zhang, Q., Liu, R., Wang, Z., Tang, N., Liu, F., Huang, G., Jiang, X., Gui, G., Wang, L., et al. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.026 · Cited by 41 · see citing works
Morrone, M. D. S., Schnorr, C. E., Behr, G. A., Gasparotto, J., Bortolin, R. C., Moresco, K. S., Bittencourt, L. D. S., Zanotto‐Filho, A., Gelain, D. P., & Moreira, J. C. F. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.03.010 · Cited by 36 · see citing works
Pierucci, M., Galati, S., Valentino, M., Matteo, V. D., Benigno, A., Pitruzzella, A., Muscat, R., & Giovanni, G. D. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711798072329 · Cited by 33 · see citing works
Moreno, L. C. G. E. A. I., Oliveira, G. Z. D. S., Cavalcanti, I. M. F., Santos-Magalhães, N. S., Rolim, H. M. L., & de Freitas, R. M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.10.023 · Cited by 27 · see citing works
Psychopharmacological assessment of Pfaffia glomerata roots (extract BNT‐08) in rodents
Marques, L. C., Galvão, S. M. P., Espínola, E., Dias, R. F., Mattei, R., Oliveira, M. G. M., & Carlini, E. A. (2004) · Phytotherapy Research · doi:10.1002/ptr.1500 · Cited by 27 · see citing works
Wang, W., Wang, T., Feng, W., Wang, Z., Cheng, M., & Wang, Y. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.01.005 · Cited by 26 · see citing works
Justino, A. B., Barbosa, M. F., Vieira, T. N., Silva, H. C. G., Brum, E. D. S., Fialho, M. F. P., Couto, A. C. G., Saraiva, A. L., Rodrigues, V. D. M., Oliveira, S. M., et al. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103562 · Cited by 26 · see citing works
Self-citationAmbrosio, G., Wirth, D., Joseph, J. F., Mazzarino, M., de la Torre, X., Botrè, F., & Parr, M. K. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.112877 · Cited by 25 · see citing works
Direct effects of hypoxia and nitric oxide on ecdysone secretion by insect prothoracic glands
DeLalio, L. J., Dion, S. M., Bootes, A. M., & Smith, W. A. (2015) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2015.02.009 · Cited by 24 · see citing works
Tsujiyama, S., Ujihara, H., Ishihara, K., & Sasa, M. (1995) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.68.133 · Cited by 21 · see citing works
de Almeida, I. V., Düsman, E., Mattge, G. I., Toledo, F., Reusing, A. F., & Vicentini, V. E. P. (2017) · Genetics and Molecular Research · doi:10.4238/gmr16039785 · Cited by 13 · see citing works
Hypnotic effect of ecdysterone isolated from Pfaffia glomerata (Spreng.) Pedersen
Fenner, R., Zimmer, A. R., Neves, G. A., Kliemann, M. P., Gosmann, G., & Rates, S. M. K. (2008) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2008000200005 · Cited by 11 · see citing works
Avaliacao da acao adaptogena das raizes de Pfaffia glomerata (Sprengel) pedersen- amaranthaceae
Marques, L. C. (1998) · UNIFESP Institutional Repository (Universidade Federal de São Paulo) · Cited by 8 · see citing works
Vigo, C. L. S., Narita, E., Nakamura, C. V., & Marques, L. C. (2003) · Revista Brasileira de Farmacognosia · doi:10.1590/s0102-695x2003000400006 · Cited by 6 · see citing works
Pandya, A. (2009) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.7.2.foc155 · Cited by 5 · see citing works
Dobrek, Ł. (2019) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dinan, L., Dioh, W., Veillet, S., & Lafont, R. (2021) · Biomedicines · doi:10.3390/biomedicines9050492 · Cited by 99 · see citing works
Gholipour, P., Komaki, A., Parsa, H., & Ramezani, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03603-2 · Cited by 43 · see citing works
Esmaealzadeh, N., Iranpanah, A., Sarris, J. J., & Rahimi, R. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154354 · Cited by 45 · see citing works
Ecdysterone and Turkesterone—Compounds with Prominent Potential in Sport and Healthy Nutrition
Todorova, V., Ivanova, S., Chakarov, D., Kraev, K., & Ivanov, K. (2024) · Nutrients · doi:10.3390/nu16091382 · Cited by 31 · see citing works
“Within these studies, no serious [50] The effects of 20HE in ovariectomized rats on morphological changes in the joint, epiphyseal cartilage, and trabecular tissue.”
BackgroundPérez-Piñero, S., Ávila-Gandía, V., Rubio Arias, J. A., Muñoz-Carrillo, J. C., Losada-Zafrilla, P., & López-Román, F. J. (2021) · Nutrients · doi:10.3390/nu13124373 · Cited by 21 · see citing works
Fortini, E. A., Batista, D. S., Felipe, S. H. S., Silva, T. D., Correia, L. N. F., Farias, L. M., Faria, D. V., Pinto, V. B., Santa‐Catarina, C., Silveira, V., et al. (2022) · PROTOPLASMA · doi:10.1007/s00709-022-01789-4 · Cited by 15 · see citing works
Self-citationRibeiro, S. T. C., Gancedo, N. C., de Oliveira, A. J. B., & Gonçalves, R. A. C. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118003 · Cited by 12 · see citing works
Sidorova, Y. S., Shipelin, V. A., Petrov, N. A., Zorin, S. N., & Mazo, V. K. (2022) · Molecules · doi:10.3390/molecules27249003 · Cited by 11 · see citing works
Teixeira, T. M., Boeff, D. D., Carvalho, L. D. O., Ritter, M. R., & Konrath, E. L. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116876 · Cited by 12 · see citing works
Zádor, E. (2025) · Cells · doi:10.3390/cells14060431 · Cited by 9 · see citing works
“Stress, anxiety, and depression were reduced in mice by a 20E-enriched fraction of Pfafia glomerulata roots [53].”
Gholipour, P., Komaki, A., Parsa, H., & Ramezani, M. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05168-x · Cited by 10 · see citing works
Shuvalov, O., Kirdeeva, Y., Fefilova, E., Daks, A., Fedorova, O., Parfenyev, S., Nazarov, A., Vlasova, Y., Krasnov, G. S., & Barlev, N. A. (2024) · Antioxidants · doi:10.3390/antiox13111349 · Cited by 9 · see citing works
Unlocking nature's potential: The power of adaptogens in enhancing modern health and wellness
Jahan, F. M., Razavi, S. H., Nouri, M., Shafiepour, M., & Afraei, M. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.102501 · Cited by 9 · see citing works
Sripinyowanich, S., Petchsri, S., Tongyoo, P., Lee, T., Lee, S., & Cho, W. K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032397 · Cited by 7 · see citing works
Todorova, V., Todorova, M. N., Savova, M. S., Ivanov, K., Georgiev, M. I., & Ivanova, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083739 · Cited by 7 · see citing works
Franco, R. R., Franco, R. M., Justino, A. B., Borges, A. L. S., Bittar, V. P., Saito, N., Saraiva, A. L., Nicolau-Júnior, N., Otoni, W. C., & Espíndola, F. S. (2024) · PROTOPLASMA · doi:10.1007/s00709-023-01916-9 · Cited by 5 · see citing works
Self-citationChemical characterization and bioactivities of fructans from Pfaffia glomerata roots
Ribeiro, S. T. C., da Silva, T. F. O., Castro, J. C., Cabral, M. R. P., Filho, B. A. D. A., de Oliveira, A. J. B., & Gonçalves, R. A. C. (2021) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2021.100303 · Cited by 5 · see citing works
Chemical Constituents, Neuroprotective and Antioxidant Potential of Klasea centauroides Leaves
Разуваева, Я. Г., Markova, K. V., Алексеевна, Т. А., Kashchenko, N. I., & Olennikov, D. N. (2023) · Applied Sciences · doi:10.3390/app13020860 · Cited by 5 · see citing works
da Silva, J. V. S., Silva, T. D., Felipe, S. H. S., Batista, D. S., Henschel, J. M., Fortini, E. A., Farias, L. M., Leite, J. P. V., de Almeida, M. M. V., Machado, K. L. D. G., et al. (2025) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-025-03071-w · Cited by 3 · see citing works
Self-citationGelves, D. I. A., de Souza, G. C. A., Tasco, A. J. H., & Salvador, M. J. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202500530 · Cited by 4 · see citing works
Effects of an L-Leucine-Rich Diet on Liver and Kidneys in a Doxorubicin Toxicity Model
Duarte, P. R. A., Franco, R. R., Vilela, D. D., Caixeta, D. C., de Souza, A. V., Deconte, S. R., Mendes‐Rodrigues, C., Fidale, T. M., Espíndola, F. S., Teixeira, R. R., et al. (2023) · Life · doi:10.3390/life13091823 · Cited by 3 · see citing works
Self-citationda Silva, J. V. S., Silva, T. D., Felipe, S. H. S., Henschel, J. M., Batista, D. S., Fortini, E. A., Farias, L. M., de Almeida, M. M. V., Leite, J. P. V., Machado, K. L. D. G., et al. (2026) · PROTOPLASMA · doi:10.1007/s00709-026-02193-y · Cited by 1 · see citing works
Self-citationAntioxidant potential of Pfaffia glomerata and Arrabidaea chica extracts combination
Souza, L. D. Z. D. S., Ferrari, A., & Felipe, D. F. (2021) · Research Society and Development · doi:10.33448/rsd-v10i4.14150 · Cited by 1 · see citing works
Júnior, F. D. B., Marquezi, L. C., Sakai, O. A., & Terhaag, M. M. (2021) · Research Society and Development · doi:10.33448/rsd-v10i4.14147 · Cited by 2 · see citing works
Markova, K. V., Алексеевна, Т. А., Разуваева, Я. Г., & Olennikov, D. N. (2022) · Бюллетень Восточно-Сибирского научного центра Сибирского отделения Российской академии медицинских наук · doi:10.29413/abs.2022-7.1.4 · Cited by 1 · see citing works
Bonilla, A. M., Garrido, G., Consolini, A. E., & Ragone, M. I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.26.696583 · Cited by 1 · see citing works
Como os adaptógenos influenciam a performance cognitivo-mental: uma revisão integrativa
Zago, Â., & Negro‐Dellacqua, M. (2022) · Research Society and Development · doi:10.33448/rsd-v11i10.32635
Prudente, C. M., Ramos, C. S., Rodrigues, D. S., & de Oliveira, C. J. F. (2024) · DELOS Desarrollo Local Sostenible · doi:10.55905/rdelosv17.n53-022
Zhenguang, S., Bin, Y., Wang, F., Dongmei, Y., Xiaoqing, Z., Huang, L., Xuemei, G., Ли, Б., & Luqi, H. (2024) · PubMed Central · doi:10.19852/j.cnki.jtcm.20240521.001
Melatonin Alleviates Aluminum Toxicity in Pfaffia glomerata by Modulating Tolerance Mechanisms
de Almeida, M. M. V., Henschel, J. M., Silva, T. D., Monteiro, L. E. G., Rodrigues, M. S., de Oliveira, T. D. R., Martins, A. O., Felipe, S. H. S., Fortini, E. A., de Matos, E. M., et al. (2026) · Journal of Plant Growth Regulation · doi:10.1007/s00344-025-12031-9
Self-citationPhysiological and Proteomic Shifts in Pfaffia glomerata Under Drought and Elevated CO₂
Silva, T. D., Fortini, E. A., Batista, D. S., Robledo, K. J. M., Machado, M. R., Felipe, S. H. S., de Oliveira, T. D. R., Andrade, M. T., Farias, L. M., Santa‐Catarina, C., et al. (2026) · Journal of Plant Growth Regulation · doi:10.1007/s00344-026-12117-y
Self-citationRazuvaeva, Y., Хобракова, В. Б., Shobolov, B. P., Olennikov, D. N., & Baldanova, I. (2026) · Problems of Biological Medical and Pharmaceutical Chemistry · doi:10.29296/25877313-2026-08-10
de Azevedo, M. M., Silva, M. L. F., da Silva, G. P., Miranda, J., Moraes, A. V., Pael, L. A. B., de Carvalho, T. L. G. S., Calaça, G. N., Silva, T. A. R., Silva, B. V., et al. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18091074
Lafetá, S. A., Vieira, T. N., Franco, R. R., Couto, A. C. G., Bittar, V. P., Carrillo, M. S. P., Teixeira, R. R., Saraiva, A. L., Justino, A. B., da Silva, T., et al. (2026) · Brain and Behavior · doi:10.1002/brb3.71819
Self-citation
- Authors
- Franco, R. R., de Almeida Takata, L., Chagas, K., Justino, A. B., Saraiva, A. L., Goulart, L. R., de Melo Rodrigues Ávila, V., Otoni, W. C., Espindola, F. S., & da Silva, C. R.
- Affiliations
- Universidade Federal de Uberlândia (BR)
- Universidade Federal de Viçosa (BR)
- ORCID
- Venue
- Journal of Ethnopharmacology
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 267
- Pages
- 113599
- ISSN
- 0378-8741 (ISSN-L)
- OpenAlex
- W3098904688
- Semantic Scholar
- ac3855c456205910872184f8de9958741dc15b96
- Cited by
- 34
- References
- 49
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 5
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Ethnopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- FAPEMIG (APQ-01856-14, CNPq-465669/2014-0, FAPEMIG-CBB-APQ-03613-17)
- CNPq (308965/2015-9)
- CAPES
- National Council for Scientific and Technological Development
- Coordination for the Improvement of Higher Education Personnel
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Keywords
- Pfaffia glomerata, 20-hydroxyecdysone, phytosteroids, roots, neuroprotection, stress, anxiety, depression, oxidative stress, antioxidant enzymes, lipid peroxidation, nitric oxide, striatum, hippocampus, cortex, memory, ethnomedicine
- MeSH terms
- Animals, Antidepressive Agents, Antioxidants, Anxiety, Behavior, Animal, Brain, Depression, Disease Models, Animal, Ecdysterone, Exploratory Behavior, Male, Memory, Mice, Inbred C57BL, Motor Activity, Plant Extracts, Stress, Psychological, Anti-Anxiety Agents, Lipid Peroxidation, Biomarkers, Oxidative Stress, Plant Roots, Amaranthaceae, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
