New Experiences Enhance Coordinated Neural Activity in the Hippocampus
Open accessAbstract
The acquisition of new memories for places and events requires synaptic plasticity in the hippocampus, and plasticity depends on temporal coordination among neurons. Spatial activity in the hippocampus is relatively disorganized during the initial exploration of a novel environment, however, and it is unclear how neural activity during the initial stages of learning drives synaptic plasticity. Here we show that pairs of CA1 cells that represent overlapping novel locations are initially more coactive and more precisely coordinated than are cells representing overlapping familiar locations. This increased coordination occurs specifically during brief, high-frequency events (HFEs) in the local field potential that are similar to ripples and is not associated with better coordination of place-specific neural activity outside of HFEs. As novel locations become more familiar, correlations between cell pairs decrease. Thus, hippocampal neural activity during learning has a unique structure that is well suited to induce synaptic plasticity and to allow for rapid storage of new memories.
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Wake reactivations occur conjointly with SW-Rs that are observed at somewhat lower rates during wakefulness than during SWS.
“They also occur conjointly with SW-Rs that are observed at somewhat lower rates during wakefulness than during SWS (159,191,870).”
From About Sleep's Role in Memory (2013) · cites this paper as [191]
The Introduction (page unavailable) says reactivation occurs during waking activity and is most prevalent during ripples. It also says ripples are dominant during quiescence or slow-wave sleep but can occur during running; it does not establish that their rate is somewhat lower during wakefulness than during slow-wave sleep. (LLM, conf=0.86)
Experimental — accuracy not yet measuredReactivations of hippocampal cell firing patterns occur also during waking when the animal rests after task performance or during brief pauses of active behavior.
“Reactivations of hippocampal cell firing patterns occur also during waking when the animal rests after task performance or during brief pauses of active behavior like explo-ration or running in a maze (191, 268, 556, 673, 870; see Ref. 175 for a review).”
From About Sleep's Role in Memory (2013) · cites this paper as [191]
The Introduction (page unavailable) describes hippocampal firing-pattern reactivation during waking activity and says the associated ripples occur during quiescence and running. It does not specifically place waking reactivation in rest after task performance or in brief pauses during exploration or maze running. (LLM, conf=0.82)
Experimental — accuracy not yet measuredWake reactivations were found to be particularly precise when the animal explores a novel environment, and the precision decreases when the animal becomes more and more familiar with the spatial task.
“Wake reactivations were found to be particularly precise when the animal explores a novel environment, and the precision decreases when the animal becomes more and more familiar with the spatial task (191).”
From About Sleep's Role in Memory (2013) · cites this paper as [191]
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- Authors
- Cheng, S., & Frank, L. M.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Frank, Loren M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 57
- Issue
- 2
- Pages
- 303-313
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2244590
- OpenAlex
- W2143853187
- Cited by
- 286
- References
- 53
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 14 · 2023: 18 · 2022: 14 · 2021: 19 · 2020: 18 · 2019: 24 · 2018: 23 · 2017: 13 · 2016: 14 · 2015: 11 · 2014: 22 · 2013: 10 · 2012: 11
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2055 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- McKnight Foundation
- National Institutes of Health (MH080283)
- National Institute of Mental Health (R01MH080283, MH080283, P50MH077970, MH059733, MH 077970, R01MH059733)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, CA1, synaptic plasticity, neural coordination, place learning, novel environment, ripples, local field potentials, spatial activity, memory encoding
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Dose-Response Relationship, Radiation, Electric Stimulation, Hippocampus, Male, Models, Neurological, Nerve Net, Neuronal Plasticity, Neurons, Space Perception, Spatial Behavior, Statistics as Topic, Time Factors, Nonlinear Dynamics, Maze Learning, Rats, Long-Evans, Rats
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