Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: mood-congruent memory in male mice?
Open accessAbstract
BACKGROUND: Although mood-congruent memory (MCM), or the tendency to recall information consistent with one's mood, is a robust phenomenon in human depression, to our knowledge, it has never been demonstrated in animals. METHODS: Mice were subjected to social isolation (SI) or crowding for 12 hours and had their depressive-like behaviour (evaluated by the forced swim, tail suspension, sucrose preference and splash tests) or their serum corticosterone concentrations evaluated. In addition, we determined the temporal forgetting curve of the plus-maze discriminative avoidance task (PM-DAT) and examined the effects of SI or crowding on memory retrieval in the PM-DAT. Finally, we verified the effects of metyrapone pretreatment on reinstatement of memory retrieval or on the increase of corticosterone levels induced by SI. RESULTS: Twelve hours of SI produced depressive-like behaviour, enhanced corticosterone concentration and reinstated retrieval of a forgotten discriminative aversive (i.e., negatively valenced) task. Depressive-like behaviour was critical for this facilitative effect of SI because 12 hours of crowding neither induced depressive-like behaviour nor enhanced retrieval, although it increased corticosterone levels at the same magnitude as SI. However, corticosterone increase was a necessary condition for MCM in mice, in that the corticosterone synthesis inhibitor metyrapone abolished SI-induced retrieval reinstatement. LIMITATIONS: Our study did not investigate the effects of the social manipulations proposed here in a positively valenced task. CONCLUSION: To our knowledge, the present paper provides the first evidence of MCM in animal models.
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Peripheral corticosterone is increased in male mice isolated for 12 hours.
“Peripheral corticosterone levels are also reportedly increased in male mice isolated for 12 h,73”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [73]
Acute social isolation in rodents is sufficient to cause behavioral abnormalities, including increased vulnerability to drug addiction and depressive-like behavior, later in life.
“During adolescence, social and cognitive skills depend on peer-to-peer interactions (Vanderschuren et al., 1997; Baarendse et al., 2013), and acute social isolation in rodents is sufficient to cause behavioral abnormalities, including increased vulnerability to drug addiction and depressive-like behavior, later in life (Lampert et al., 2017; Takatsu-Coleman et al., 2013; Whitaker et al., 2013).”
From Oxytocin neurons mediate the effect of social isolation via the VTA circuits (2022) · cites this paper as Takatsu-Coleman et al., 2013
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Examining the central effects of chronic stressful social isolation on rats
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“Most published studies show that SI has a depressive action, apparent as a reduction in preference for sucrose solution and an increase in total freezing time in the forced swimming test, sometimes apparent as no more than a single sign [Guarnieri et al., 2020; Wang et al., 2017; Mileva and Bielajew, 2015; Takatsu-Col…”
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Effects of maternal social isolation on adult rodent offspring cognition
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Effects of age and social isolation on murine hippocampal biochemistry and behavior
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Food restriction increases long-term memory persistence in adult or aged mice
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“★p b 0.05 compared to the Adult-CTRL group and ♦p b 0.05 compared to the Aged-Pretest-FR group (ANOVA and Duncan's test). a forgotten memory in the PM-DAT (Takatsu-Coleman et al., 2013a,b,c).”
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Trait sensitivity to stress and cognitive bias processes in fish: A brief overview
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Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions
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BackgroundOSO paradigm – A rapid behavioral screening method for acute psychosocial stress reactivity in mice
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“During the overnight (12 h) period, they experienced water and food deprivation and were unable to make visual contact with others (Franco et al. 2021 ; Takatsu-Coleman et al. 2013 ).”
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- Authors
- Takatsu-Coleman, A. L., Patti, C. L., Zanin, K. A., Zager, A., Carvalho, R. C., Borçoi, A. R., Ceccon, L. M. B., Berro, L. F., Tufik, S., Andersen, M. L., & Frussa-Filho, R.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Departamento de Farmacologia, UNIFESP, São Paulo, Brazil
- Corresponding author
- Takatsu-Coleman, André L.
- Venue
- Journal of Psychiatry and Neuroscience
- Publisher
- Canadian Science Publishing
- Published
- 2013-07
- Volume
- 38
- Issue
- 4
- Pages
- 259-268
- ISSN
- 1180-4882 (ISSN-L)
- 1488-2434
- PMC
- PMC3692723
- OpenAlex
- W2120872618
- Cited by
- 66
- References
- 57
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 9 · 2019: 3 · 2018: 5 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 5 · 2013: 2
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Psychiatry and Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- mood-congruent memory, social isolation, depression-like behavior, corticosterone, metyrapone, aversive memory, animal models of depression, crowding
- MeSH terms
- Affect, Animals, Avoidance Learning, Behavior, Animal, Corticosterone, Crowding, Depression, Discrimination, Psychological, Male, Metyrapone, Mental Recall, Social Isolation, Models, Animal, Mice
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