Cited by 20Genomics, phytochemicals, and oxidative stressEdible Oils Quality and AnalysisAntioxidant Activity and Oxidative Stress

Chia (Salvia hispanica L.) oil supplementation ameliorates liver oxidative stress in high-fat diet-fed mice through PPAR-γ and Nrf2 upregulation

Open access
Batista, Aline, Quitete, Fernanda Torres, Peixoto, Thamara Cherem, Almo, André, Monteiro, Elisa Bernardes, Trindade, Patrícia, Zago, Lilia, Citelli, Marta +1 more·2023·Journal of Functional Foods

Abstract

This study aimed to evaluate the hepatic antioxidant activity of a high-fat diet supplemented with chia oil in mice. Forty animals were divided into Control (C, n = 10), Control + 1.5 % chia oil (CC, n = 10), High fat (HF, n = 10), and High fat + 1.5 % chia oil (HFC, n = 10) groups. Chia oil reduced serum triacylglycerol in the HF group (p < 0.05). Chia oil promotes lower hepatic concentrations of F2-isoprostane (8-epi PGF2α) and thiobarbituric acid (TBARs) than HF. Chia oil increased liver protein expression and activity of superoxide dismutase 1 and 2 (SOD1 and SOD2), catalase (CAT), and glutathione peroxidase (GPx). It also upregulated the expression of PPAR-γ and NRF2, a master transcription factor involved in the antioxidant response in the liver, compared to their counterparts. The results reveal that chia oil improves the metabolic and antioxidant systems in the liver of high-fat diet-fed mice.

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Crossref · 10.1016/j.jff.2023.105462

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Authors
Batista, A., Quitete, F. T., Peixoto, T. C., Almo, A., Monteiro, E. B., Trindade, P., Zago, L., Citelli, M., & Daleprane, J. B.
Affiliations
Universidade do Estado do Rio de Janeiro (BR)
Venue
Journal of Functional Foods
Publisher
Elsevier BV
Published
2023-03
Volume
102
Pages
105462
ISSN
1756-4646 (ISSN-L)
OpenAlex
W4321336655
Cited by
20
References
49
Citations by year
2026: 3 · 2025: 7 · 2024: 8 · 2023: 2
FWCI
1.78
Type
journal article
Language
en
Open access
Locations
  • Journal of Functional Foods (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/210.064/2021, E-26/202.677/2018)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
chia oil, Salvia hispanica, high-fat diet, hepatic oxidative stress, PPARγ, Nrf2, antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, lipid peroxidation, F2-isoprostanes, triglycerides, dietary supplementation

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