Chia (Salvia hispanica L.) oil supplementation ameliorates liver oxidative stress in high-fat diet-fed mice through PPAR-γ and Nrf2 upregulation
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This study aimed to evaluate the hepatic antioxidant activity of a high-fat diet supplemented with chia oil in mice. Forty animals were divided into Control (C, n = 10), Control + 1.5 % chia oil (CC, n = 10), High fat (HF, n = 10), and High fat + 1.5 % chia oil (HFC, n = 10) groups. Chia oil reduced serum triacylglycerol in the HF group (p < 0.05). Chia oil promotes lower hepatic concentrations of F2-isoprostane (8-epi PGF2α) and thiobarbituric acid (TBARs) than HF. Chia oil increased liver protein expression and activity of superoxide dismutase 1 and 2 (SOD1 and SOD2), catalase (CAT), and glutathione peroxidase (GPx). It also upregulated the expression of PPAR-γ and NRF2, a master transcription factor involved in the antioxidant response in the liver, compared to their counterparts. The results reveal that chia oil improves the metabolic and antioxidant systems in the liver of high-fat diet-fed mice.
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Supplementation of chia oil improves oxidative stress of the liver via transcription factors PPAR-γ and Nrf2 upregulation involving antioxidant responses.
“The supplementation of chia oil improves oxidative stress of the liver via transcription factors PPAR-γ and Nrf2 upregulation involving antioxidant responses [137].”
From Nutritional and Functional New Perspectives and Potential Health Benefits of Quinoa and Chia Seeds (2023) · cites this paper as [137]
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- Authors
- Batista, A., Quitete, F. T., Peixoto, T. C., Almo, A., Monteiro, E. B., Trindade, P., Zago, L., Citelli, M., & Daleprane, J. B.
- Affiliations
- Universidade do Estado do Rio de Janeiro (BR)
- Venue
- Journal of Functional Foods
- Publisher
- Elsevier BV
- Published
- 2023-03
- Volume
- 102
- Pages
- 105462
- ISSN
- 1756-4646 (ISSN-L)
- OpenAlex
- W4321336655
- Cited by
- 20
- References
- 49
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 2
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Functional Foods (publishedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/210.064/2021, E-26/202.677/2018)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- chia oil, Salvia hispanica, high-fat diet, hepatic oxidative stress, PPARγ, Nrf2, antioxidant enzymes, superoxide dismutase, catalase, glutathione peroxidase, lipid peroxidation, F2-isoprostanes, triglycerides, dietary supplementation
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