Cited by 132Nutritional Studies and DietNutrition, Genetics, and DiseaseDiet, Metabolism, and Disease

A Dietary Pattern Including Nopal, Chia Seed, Soy Protein, and Oat Reduces Serum Triglycerides and Glucose Intolerance in Patients with Metabolic Syndrome

Open access
Guevara-Cruz, Martha, Tovar, Armando R., Aguilar-Salinas, Carlos A., Medina-Vera, Isabel, Gil-Zenteno, Lidia, Hernández-Viveros, Isaac, López-Romero, Patricia, Ordaz-Nava, Guillermo +3 more·2012·The Journal of Nutrition

Abstract

Metabolic syndrome (MetS) is a health problem throughout the world and is associated with cardiovascular disease and diabetes. Thus, the purpose of the present work was to evaluate the effects of a dietary pattern (DP; soy protein, nopal, chia seed, and oat) on the biochemical variables of MetS, the AUC for glucose and insulin, glucose intolerance (GI), the relationship of the presence of certain polymorphisms related to MetS, and the response to the DP. In this randomized trial, the participants consumed their habitual diet but reduced by 500 kcal for 2 wk. They were then assigned to the placebo (P; n = 35) or DP (n = 32) group and consumed the reduced energy diet plus the P or DP beverage (235 kcal) minus the energy provided by these for 2 mo. All participants had decreases in body weight (BW), BMI, and waist circumference during the 2-mo treatment (P < 0.0001); however, only the DP group had decreases in serum TG, C-reactive protein (CRP), and AUC for insulin and GI after a glucose tolerance test. Interestingly, participants in the DP group with MetS and the ABCA1 R230C variant had a greater decrease in BW and an increase in serum adiponectin concentration after 2 mo of dietary treatment than those with the ABCA1 R230R variant. The results from this study suggest that lifestyle interventions involving specific DP for the treatment of MetS could be more effective if local foods and genetic variations of the population are considered.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3945/jn.111.147447

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Chia seeds' high insoluble fiber content lowers blood pressure more effectively than soluble fiber.

    “Previous studies have highlighted the beneficial components of chia seeds for cardiovascular health, including their high insoluble fiber content, which more effectively lowers BP than soluble fiber [29, 38–41].”

    From Effects of chia seed (Salvia hispanica L.) supplementation on cardiometabolic health in overweight subjects: a systematic review and meta-analysis of RCTs (2024) · cites this paper as [29]

    The Introduction mentions fiber among the dietary pattern’s components, and the Discussion discusses oat fiber and chia’s fatty acids, but neither identifies chia as high in insoluble fiber or compares fiber types for blood-pressure reduction. Table 1 reports blood pressure for the combined dietary pattern and placebo groups, not for insoluble versus soluble fiber. Searches for those fiber terms and blood pressure found no passage supporting the attributed comparison. (LLM, conf=0.76)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

2 of the 55 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Guevara-Cruz, M., Tovar, A. R., Aguilar-Salinas, C. A., Medina-Vera, I., Gil-Zenteno, L., Hernández-Viveros, I., López-Romero, P., Ordaz-Nava, G., Canizales-Quinteros, S., Guillen Pineda, L. E., & Torres, N.
Affiliations
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
Corresponding author
Torres, Nimbe
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2012-01
Volume
142
Issue
1
Pages
64-69
ISSN
0022-3166 (ISSN-L)
OpenAlex
W2137491276
Cited by
132
References
55
Citations by year
2026: 3 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 21 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 12 · 2017: 8 · 2016: 5 · 2015: 12 · 2014: 6 · 2013: 6 · 2012: 5
FWCI
5.34
Type
journal article
Language
en
Open access
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords
metabolic syndrome, dietary habits, nopal, Salvia hispanica, soy protein, oat, serum triglycerides, impaired glucose tolerance, insulin, C-reactive protein, adiponectin, genetic variation, weight loss, hypocaloric diet, lifestyle intervention, local food
MeSH terms
Adult, Blood Glucose, Diet, Double-Blind Method, Glucose Tolerance Test, Humans, Insulin, Middle Aged, Placebos, Seeds, Triglycerides, Avena, Area Under Curve, Metabolic Syndrome, Soybean Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review