A Dietary Pattern Including Nopal, Chia Seed, Soy Protein, and Oat Reduces Serum Triglycerides and Glucose Intolerance in Patients with Metabolic Syndrome
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Metabolic syndrome (MetS) is a health problem throughout the world and is associated with cardiovascular disease and diabetes. Thus, the purpose of the present work was to evaluate the effects of a dietary pattern (DP; soy protein, nopal, chia seed, and oat) on the biochemical variables of MetS, the AUC for glucose and insulin, glucose intolerance (GI), the relationship of the presence of certain polymorphisms related to MetS, and the response to the DP. In this randomized trial, the participants consumed their habitual diet but reduced by 500 kcal for 2 wk. They were then assigned to the placebo (P; n = 35) or DP (n = 32) group and consumed the reduced energy diet plus the P or DP beverage (235 kcal) minus the energy provided by these for 2 mo. All participants had decreases in body weight (BW), BMI, and waist circumference during the 2-mo treatment (P < 0.0001); however, only the DP group had decreases in serum TG, C-reactive protein (CRP), and AUC for insulin and GI after a glucose tolerance test. Interestingly, participants in the DP group with MetS and the ABCA1 R230C variant had a greater decrease in BW and an increase in serum adiponectin concentration after 2 mo of dietary treatment than those with the ABCA1 R230R variant. The results from this study suggest that lifestyle interventions involving specific DP for the treatment of MetS could be more effective if local foods and genetic variations of the population are considered.
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Chia seeds' high insoluble fiber content lowers blood pressure more effectively than soluble fiber.
“Previous studies have highlighted the beneficial components of chia seeds for cardiovascular health, including their high insoluble fiber content, which more effectively lowers BP than soluble fiber [29, 38–41].”
From Effects of chia seed (Salvia hispanica L.) supplementation on cardiometabolic health in overweight subjects: a systematic review and meta-analysis of RCTs (2024) · cites this paper as [29]
The Introduction mentions fiber among the dietary pattern’s components, and the Discussion discusses oat fiber and chia’s fatty acids, but neither identifies chia as high in insoluble fiber or compares fiber types for blood-pressure reduction. Table 1 reports blood pressure for the combined dietary pattern and placebo groups, not for insoluble versus soluble fiber. Searches for those fiber terms and blood pressure found no passage supporting the attributed comparison. (LLM, conf=0.76)
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“For example, Guevara-Cruz et al. [29] demonstrated a significant decrease in WC in individuals with metabolic syndrome who consumed a regular diet, including chia seeds, soy, nopal, and oats.”
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- Authors
- Guevara-Cruz, M., Tovar, A. R., Aguilar-Salinas, C. A., Medina-Vera, I., Gil-Zenteno, L., Hernández-Viveros, I., López-Romero, P., Ordaz-Nava, G., Canizales-Quinteros, S., Guillen Pineda, L. E., & Torres, N.
- Affiliations
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Corresponding author
- Torres, Nimbe
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 142
- Issue
- 1
- Pages
- 64-69
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2137491276
- Cited by
- 132
- References
- 55
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 21 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 12 · 2017: 8 · 2016: 5 · 2015: 12 · 2014: 6 · 2013: 6 · 2012: 5
- FWCI
- 5.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- metabolic syndrome, dietary habits, nopal, Salvia hispanica, soy protein, oat, serum triglycerides, impaired glucose tolerance, insulin, C-reactive protein, adiponectin, genetic variation, weight loss, hypocaloric diet, lifestyle intervention, local food
- MeSH terms
- Adult, Blood Glucose, Diet, Double-Blind Method, Glucose Tolerance Test, Humans, Insulin, Middle Aged, Placebos, Seeds, Triglycerides, Avena, Area Under Curve, Metabolic Syndrome, Soybean Proteins
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