SIRT3 regulation of mitochondrial oxidative stress
Abstract
Mitochondria play a central role in the production of reactive oxygen species as byproducts of metabolism and energy production. In order to protect cellular structures from oxidative stress-induced damage, cells have evolved elegant mechanisms for mitochondrial ROS detoxification. The mitochondrial sirtuin, SIRT3, is emerging as a pivotal regulator of oxidative stress by deacetylation of substrates involved in both ROS production and detoxification. This review will summarize recent findings on the regulation of mitochondrial ROS homeostasis by SIRT3.
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SIRT3 is the primary mitochondrial acetyllysine deacetylase that modulates various proteins to control mitochondrial function and mitochondrial reactive oxygen species homeostasis.
“Sirtuin 3 (SIRT3), an important member of the Sir2 family, has been identified as the primary mitochondrial acetylysine deacetylase that modulates various proteins to control mitochondrial function and mtROS homeostasis.16”
From Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway (2017) · cites this paper as [16]
SIRT3 serves as a primary regulator of mitochondrial protein acetylation, involved in regulation of energy production and mtROS homeostasis.
“SIRT3, a mitochondrial sirtuin, serves as a primary regulator of mitochondrial protein acetylation, which is involved in the regulation of energy production and mtROS homeostasis.16”
From Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway (2017) · cites this paper as [16]
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- Authors
- Bause, A. S., & Haigis, M. C.
- Affiliations
- Harvard University (US)
- Corresponding author
- Haigis, Marcia C.
- ORCID
- Haigis, Marcia C.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 48
- Issue
- 7
- Pages
- 634-639
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2007923680
- Cited by
- 311
- References
- 56
- Citations by year
- 2026: 20 · 2025: 14 · 2024: 36 · 2023: 23 · 2022: 36 · 2021: 29 · 2020: 32 · 2019: 19 · 2018: 23 · 2017: 23 · 2016: 23 · 2015: 14 · 2014: 12 · 2013: 6 · 2012: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- German Academic Exchange Service
- Glenn Foundation for Medical Research
- Ellison Medical Foundation
- NIH Grant (AG032375)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- SIRT3, mitochondrial sirtuins, mitochondrial oxidative stress, reactive oxygen species, reactive oxygen species scavenging, deacetylation
- MeSH terms
- Age Factors, Aging, Animals, Homeostasis, Humans, Mitochondria, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Sirtuin 3
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