The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Met as a therapeutic target in HCC: Facts and hopes
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MET is overexpressed in HCC.
“since MET is known to be overexpressed in this type of tumor [42]”
From Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth (2021) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sorafenib in advanced hepatocellular carcinoma
Llovet, J. M., Ricci, S., Mazzaferro, V., Hilgard, P., Gane, E., Blanc, J.-F., de Oliveira, A. C., Santoro, A., Raoul, J.-L., Forner, A., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708857 · Cited by 13,097
Bussolino, F., Di Renzo, M. F., Ziche, M., Bocchietto, E., Olivero, M., Naldini, L., Gaudino, G., Tamagnone, L., Coffer, A., & Comoglio, P. M. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.629 · Cited by 1,337
Flagged first, then by citations
Research works printed but not linked: 87
- Jemal, 2011, Global cancer statistics, CA Cancer J Clin, 61, 69, 10.3322/caac.20107 · DOI
- Llovet, 2008, Design and endpoints of clinical trials in hepatocellular carcinoma, J Natl Cancer Inst, 100, 698, 10.1093/jnci/djn134 · DOI
- Llovet, 2008, Molecular targeted therapies in hepatocellular carcinoma, Hepatology, 48, 1312, 10.1002/hep.22506 · DOI
- Luo, 2009, Principles of cancer therapy: oncogene and non-oncogene addiction, Cell, 136, 823, 10.1016/j.cell.2009.02.024 · DOI · Paper page
- Giordano, 1989, Tyrosine kinase receptor indistinguishable from the c-met protein, Nature, 339, 155, 10.1038/339155a0 · DOI
- Corso, 2013, Cell autonomous and non-cell autonomous mechanisms of HGF/MET-driven resistance to targeted therapies: from basic research to a clinical perspective, Cancer Discov, 3, 978, 10.1158/2159-8290.CD-13-0040 · DOI
- Bottaro, 1991, Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product, Science, 251, 802, 10.1126/science.1846706 · DOI
- Naldini, 1991, Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET, Oncogene, 6, 501
- Birchmeier, 2003, Met, metastasis, motility and more, Nat Rev Mol Cell Biol, 4, 915, 10.1038/nrm1261 · DOI
- Migliore, 2008, Molecular cancer therapy: can our expectation be MET?, Eur J Cancer, 44, 641, 10.1016/j.ejca.2008.01.022 · DOI
- van der Voort, 1999, Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met, J Biol Chem, 274, 6499, 10.1074/jbc.274.10.6499 · DOI
- Orian-Rousseau, 2002, CD44 is required for two consecutive steps in HGF/c-Met signaling, Genes Dev, 16, 3074, 10.1101/gad.242602 · DOI
- Trusolino, 2001, A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth, Cell, 107, 643, 10.1016/S0092-8674(01)00567-0 · DOI
- Giordano, 2002, The semaphorin 4D receptor controls invasive growth by coupling with Met, Nat Cell Biol, 4, 720, 10.1038/ncb843 · DOI
- Jo, 2000, Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells, J Biol Chem, 275, 8806, 10.1074/jbc.275.12.8806 · DOI · Paper page
- Bergstrom, 2000, Epidermal growth factor receptor signaling activates met in human anaplastic thyroid carcinoma cells, Exp Cell Res, 259, 293, 10.1006/excr.2000.4967 · DOI
- Fischer, 2004, Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells, J Biol Chem, 279, 28970, 10.1074/jbc.M402508200 · DOI
- Lu, 2012, VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex, Cancer Cell, 22, 21, 10.1016/j.ccr.2012.05.037 · DOI
- Wang, 2002, A mechanism of cell survival: sequestration of Fas by the HGF receptor Met, Mol Cell, 9, 411, 10.1016/S1097-2765(02)00439-2 · DOI · Paper page
- Sakata, 1996, Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers, Cell Growth Differ, 7, 1513
- Wang, 2001, Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice, J Cell Biol, 153, 1023, 10.1083/jcb.153.5.1023 · DOI
- Takayama, 1997, Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor, Proc Natl Acad Sci U S A, 94, 701, 10.1073/pnas.94.2.701 · DOI
- Liang, 1996, Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors, J Clin Invest, 97, 2872, 10.1172/JCI118744 · DOI
- Comoglio, 2008, Drug development of MET inhibitors: targeting oncogene addiction and expedience, Nat Rev Drug Discov, 7, 504, 10.1038/nrd2530 · DOI
- Schmidt, 1997, Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas, Nat Genet, 16, 68, 10.1038/ng0597-68 · DOI
- Michieli, 1999, Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists, Oncogene, 18, 5221, 10.1038/sj.onc.1202899 · DOI
- Nakamura, 1984, Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats, Biochem Biophys Res Commun, 122, 1450, 10.1016/0006-291X(84)91253-1 · DOI · Paper page
- Nakamura, 1989, Molecular cloning and expression of human hepatocyte growth factor, Nature, 342, 440, 10.1038/342440a0 · DOI
- Furlong, 1991, Comparison of biological and immunochemical properties indicates that scatter factor and hepatocyte growth factor are indistinguishable, J Cell Sci, 100, 173, 10.1242/jcs.100.1.173 · DOI
- Shima, 1991, Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: cloning of its cDNA, purification and characterization of recombinant protein, Biochem Biophys Res Commun, 180, 1151, 10.1016/S0006-291X(05)81187-8 · DOI
- Kosai, 1998, Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor, Biochem Biophys Res Commun, 244, 683, 10.1006/bbrc.1998.8293 · DOI
- Amicone, 1997, Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes, EMBO J, 16, 495, 10.1093/emboj/16.3.495 · DOI
- Wang, 2012, DeLeve LD Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats, J Clin Invest, 122, 1567, 10.1172/JCI58789 · DOI
- Huh, 2004, Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair, Proc Natl Acad Sci U S A, 101, 4477, 10.1073/pnas.0306068101 · DOI · Paper page
- Borowiak, 2004, Met provides essential signals for liver regeneration, Proc Natl Acad Sci U S A, 101, 10608, 10.1073/pnas.0403412101 · DOI · Paper page
- Giebeler, 2009, C-Met confers protection against chronic liver tissue damage and fibrosis progression after bile duct ligation in mice, Gastroenterology, 137, 308, 10.1053/j.gastro.2009.01.068 · DOI
- Aberger, 1996, The Xenopus homologue of hepatocyte growth factor-like protein is specifically expressed in the presumptive neural plate during gastrulation, Mech Dev, 54, 23, 10.1016/0925-4773(95)00458-0 · DOI
- Takeo, 2001, Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: comparison with comparative genomic hybridization analysis, Cancer Genet Cytogenet, 130, 127, 10.1016/S0165-4608(01)00479-4 · DOI
- Kondo, 2013, Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma, Int J Clin Oncol, 18, 207, 10.1007/s10147-011-0361-9 · DOI
- Wang, 2013, Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma, Hepatology, 58, 706, 10.1002/hep.26402 · DOI
- Guichard, 2012, Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma, Nat Genet, 44, 694, 10.1038/ng.2256 · DOI
- Jia, 2013, Cancer-associated fibroblasts from hepatocellular carcinoma promote malignant cell proliferation by HGF secretion, PLoS One, 8, e63243, 10.1371/journal.pone.0063243 · DOI
- Ueki, 1997, Expression of hepatocyte growth factor and its receptor c-met proto-oncogene in hepatocellular carcinoma, Hepatology, 25, 862, 10.1002/hep.510250413 · DOI
- Boix, 1994, C-met mRNA overexpression in human hepatocellular carcinoma, Hepatology, 19, 88, 10.1002/hep.1840190115 · DOI
- Suzuki, 1994, Expression of the c-met protooncogene in human hepatocellular carcinoma, Hepatology, 20, 1231, 10.1002/hep.1840200520 · DOI
- Noguchi, 1996, Gene expressions of c-met and hepatocyte growth factor in chronic liver disease and hepatocellular carcinoma, J Hepatol, 24, 286, 10.1016/S0168-8278(96)80006-7 · DOI
- Kiss, 1997, Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth Factor/c-met, TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas, Clin Cancer Res, 3, 1059
- Tavian, 2000, U-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma, Int J Cancer, 87, 644, 10.1002/1097-0215(20000901)87:5<644::AID-IJC4>3.0.CO;2-W · DOI
- Daveau, 2003, Hepatocyte growth factor, transforming growth factor alpha, and their receptors as combined markers of prognosis in hepatocellular carcinoma, Mol Carcinog, 36, 130, 10.1002/mc.10103 · DOI
- Suzuki, 2005, Des-gamma-carboxy prothrombin is a potential autologous growth factor for hepatocellular carcinoma, J Biol Chem, 280, 6409, 10.1074/jbc.M406714200 · DOI
- Gao, 2012, Des-gamma-carboxy prothrombin and c-Met were concurrently and extensively expressed in hepatocellular carcinoma and associated with tumor recurrence, Biosci Trends, 6, 153, 10.5582/bst.2012.v6.4.153 · DOI
- Weitz, 1993, Des-gamma-carboxy (abnormal) prothrombin and hepatocellular carcinoma: a critical review, Hepatology, 18, 990, 10.1002/hep.1840180434 · DOI
- Kaposi-Novak, 2006, Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype, J Clin Invest, 116, 1582, 10.1172/JCI27236 · DOI
- Shiota, 1992, Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells, Proc Natl Acad Sci U S A, 89, 373, 10.1073/pnas.89.1.373 · DOI
- Ogasawara, 1998, Hepatocyte growth factor stimulates DNA synthesis in rat preneoplastic hepatocytes but not in liver carcinoma cells, Gastroenterology, 114, 775, 10.1016/S0016-5085(98)70591-8 · DOI
- Nakanishi, 1999, Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via phosphatidylinositol 3-kinase, Clin Exp Metastasis, 17, 507, 10.1023/A:1006685218766 · DOI
- Shirako, 2008, Up-regulation of p21CIP1 expression mediated by ERK-dependent and -independent pathways contributes to hepatocyte growth factor-induced inhibition of HepG2 hepatoma cell proliferation, J Cell Biochem, 104, 176, 10.1002/jcb.21614 · DOI
- Zhang, 2005, Knockdown of c-Met by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo, Mol Cancer Ther, 4, 1577, 10.1158/1535-7163.MCT-05-0106 · DOI
- Salvi, 2007, In vitro c-met inhibition by antisense RNA and plasmid-based RNAi down-modulates migration and invasion of hepatocellular carcinoma cells, Int J Oncol, 31, 451
- Xie, 2010, Down-regulation of c-Met expression inhibits human HCC cells growth and invasion by RNA interference, J Surg Res, 162, 231, 10.1016/j.jss.2009.04.030 · DOI
- Schmidt, 1995, Scatter factor/hepatocyte growth factor is essential for liver development, Nature, 373, 699, 10.1038/373699a0 · DOI
- Uehara, 1995, Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor, Nature, 373, 702, 10.1038/373702a0 · DOI
- Takami, 2007, Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis, Cancer Res, 67, 9844, 10.1158/0008-5472.CAN-07-1905 · DOI
- Marx-Stoelting, 2009, Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met, Int J Cancer, 124, 1767, 10.1002/ijc.24167 · DOI
- Tward, 2005, Genomic progression in mouse models for liver tumors, Cold Spring Harb Symp Quant Biol, 70, 217, 10.1101/sqb.2005.70.058 · DOI
- Liu, 1995, Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine, Carcinogenesis, 16, 841, 10.1093/carcin/16.4.841 · DOI
- Yaono, 1995, Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine, Jpn J Cancer Res, 86, 718, 10.1111/j.1349-7006.1995.tb02459.x · DOI
- Shiota, 1994, Hepatocyte growth factor in transgenic mice: effects on hepatocyte growth, liver regeneration and gene expression, Hepatology, 19, 962, 10.1002/hep.1840190423 · DOI
- Horiguchi, 2002, Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine, Oncogene, 21, 1791, 10.1038/sj.onc.1205248 · DOI
- Santoni-Rugiu, 1996, Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model, Proc Natl Acad Sci U S A, 93, 9577, 10.1073/pnas.93.18.9577 · DOI
- Shiota, 1995, Characterization of double transgenic mice expressing hepatocye growth factor and transforming growth factor alpha, Res Commun Mol Pathol Pharmacol, 90, 17
- Zhang, 2003, Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation, Proc Natl Acad Sci U S A, 100, 12718, 10.1073/pnas.2135113100 · DOI
- Eckerich, 2007, Hypoxia can induce c-Met expression in glioma cells and enhance SF/HGF-induced cell migration, Int J Cancer, 121, 276, 10.1002/ijc.22679 · DOI
- Pennacchietti, 2003, Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene, Cancer Cell, 3, 347, 10.1016/S1535-6108(03)00085-0 · DOI · Paper page
- Rose, 2010, Mechanisms of evasion to antiangiogenic therapy in glioblastoma, Clin Neurosurg, 57, 123
- Huynh, 2012, Foretinib demonstrates anti-tumor activity and improves overall survival in preclinical models of hepatocellular carcinoma, Angiogenesis, 15, 59, 10.1007/s10456-011-9243-z · DOI
- Martell, 2012, Safety and efficacy of MET inhibitor tivantinib (ARQ 197) combined with sorafenib in patients (pts) with hepatocellular carcinoma (HCC) from a phase I study (abstract), J Clin Oncol, 30, abstr 4117, 10.1200/jco.2012.30.15_suppl.4117 · DOI
- Munshi, 2010, ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity, Mol Cancer Ther, 9, 1544, 10.1158/1535-7163.MCT-09-1173 · DOI
- Santoro, 2013, Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study, Lancet Oncol, 14, 55, 10.1016/S1470-2045(12)70490-4 · DOI
- Katayama, 2013, Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibition, Cancer Res, 73, 3087, 10.1158/0008-5472.CAN-12-3256 · DOI
- Basilico, 2013, Tivantinib (ARQ197) displays cytotoxic activity that is independent of its ability to bind MET, Clin Cancer Res, 19, 2381, 10.1158/1078-0432.CCR-12-3459 · DOI
- O’Shaughnessy, 2011, Iniparib plus chemotherapy in metastatic triple-negative breast cancer, N Engl J Med, 364, 205, 10.1056/NEJMoa1011418 · DOI · Paper page
- Liu, 2012, Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor, Clin Cancer Res, 18, 510, 10.1158/1078-0432.CCR-11-1973 · DOI
- Patel, 2012, Failure of iniparib to inhibit poly(ADP-Ribose) polymerase in vitro, Clin Cancer Res, 18, 1655, 10.1158/1078-0432.CCR-11-2890 · DOI
- Yau, 2012, A phase I/II study of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, and VEGFR in advanced hepatocellular carcinoma (HCC), J Clin Oncol, 30, 4108, 10.1200/jco.2012.30.15_suppl.4108 · DOI
- Verslype, 2012, Activity of cabozantinib (XL184) in hepatocellular carcinoma: Results from a phase II randomized discontinuation trial (RDT), J Clin Oncol, 30, 4007, 10.1200/jco.2012.30.15_suppl.4007 · DOI
- Selden, 1994, Expression of hepatocyte growth factor mRNA, and c-met mRNA (hepatocyte growth factor receptor) in human liver tumours, J Hepatol, 21, 227, 10.1016/S0168-8278(05)80400-3 · DOI
Cited by
Sorted by citations
Uemura, T., Suzuki, T., Dohmae, N., & Waguri, S. (2021) · Oncogenesis · doi:10.1038/s41389-021-00367-2 · Cited by 19
Metadata
- Authors
- Giordano, S., & Columbano, A.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 60
- Issue
- 2
- Pages
- 442-452
- ISSN
- 0168-8278
- Cited by
- 158
- References
- 2
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review