Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores
Open accessAbstract
Background & Aims Hepatocellular carcinoma (HCC) risk stratification in individuals with dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk scores (PRS) that can be evaluated in the clinic to gain insight into the causal relationship between NAFLD and HCC, and to improve HCC risk stratification. Methods We examined at-risk individuals (NAFLD cohort, n = 2,566; 226 with HCC; and a replication cohort of 427 German patients with NAFLD) and the general population (UK Biobank [UKBB] cohort, n = 364,048; 202 with HCC). Variants in PNPLA3-TM6SF2-GCKR-MBOAT7 were combined in a hepatic fat PRS (PRS-HFC), and then adjusted for HSD17B13 (PRS-5). Results In the NAFLD cohort, the adjusted impact of genetic risk variants on HCC was proportional to the predisposition to fatty liver ( p = 0.002) with some heterogeneity in the effect. PRS predicted HCC more robustly than single variants ( p < 10 -13 ). The association between PRS and HCC was mainly mediated through severe fibrosis, but was independent of fibrosis in clinically relevant subgroups, and was also observed in those without severe fibrosis ( p < 0.05). In the UKBB cohort, PRS predicted HCC independently of classical risk factors and cirrhosis ( p < 10 -7 ). In the NAFLD cohort, we identified high PRS cut-offs (≥0.532/0.495 for PRS-HFC/PRS-5) that in the UKBB cohort detected HCC with ~90% specificity but limited sensitivity; PRS predicted HCC both in individuals with ( p < 10 -5 ) and without cirrhosis ( p < 0.05). Conclusions Our results are consistent with a causal relationship between hepatic fat and HCC. PRS improved the accuracy of HCC detection and may help stratify HCC risk in individuals with dysmetabolism, including those without severe liver fibrosis. Further studies are needed to validate our findings. Lay summary By analyzing variations in genes that contribute to fatty liver disease, we developed two risk scores to help predict liver cancer in individuals with obesity-related metabolic complications. These risk scores can be easily tested in the clinic. We showed that the risk scores helped to identify the risk of liver cancer both in high-risk individuals and in the general population.
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Comprehensive polygenic risk scores are superior to PNPLA3 and TM6SF2 alone for risk prediction of progressive MASLD, especially in individuals with metabolic triggers, and the benefits of their use over clinical risk factors alone become more evident for long-term prediction.
“Comprehensive polygenic risk scores are superior to PNPLA3 and TM6SF2 alone for risk prediction of progressive MASLD, especially in individuals with metabolic triggers, and the bene fi ts of their use over clinical risk factors alone becomes more evident for long-term prediction. 196,206,207”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [206]
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Experimental — accuracy not yet measuredA model incorporating genetic variants predicted HCC independently of classical risk factors, but its AUROC when used alone was only 0.65.
“Another model incorporated genetic variants in a risk score that predicted HCC independently of classical risk factors, but the AUROC when used alone was only 0.65. 206”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [206]
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Cites
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Ferlay, J., Shin, H.-R., Bray, F., Forman, D., Mathers, C., & Parkin, D. M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25516 · Cited by 22,207 · see citing works
A global reference for human genetic variation
The 1000 Genomes Project Consortium, authors, C., Auton, A., Abecasis, G. R., Steering committee, Altshuler, D. M., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., et al. (2015) · Nature · doi:10.1038/nature15393 · Cited by 18,247 · see citing works
Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J., Downey, P., Elliott, P., Green, J., Landray, M., et al. (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001779 · Cited by 12,728 · see citing works
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
Galle, P. R., Forner, A., Llovet, J. M., Mazzaferro, V., Piscaglia, F., Raoul, J.-L., Schirmacher, P., & Vilgrain, V. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.019 · Cited by 11,406 · see citing works
The UK Biobank resource with deep phenotyping and genomic data
Bycroft, C., Freeman, C., Petkova, D., Band, G., Elliott, L. T., Sharp, K., Motyer, A., Vukcevic, D., Delaneau, O., O’Connell, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0579-z · Cited by 8,876 · see citing works
EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma
European Association for the Study of the Liver, & European Organisation for Research and Treatment of Cancer (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.12.001 · Cited by 5,218 · see citing works
EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.004 · Cited by 4,836 · see citing works
Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
Lawlor, D. A., Harbord, R. M., Sterne, J. A. C., Timpson, N., & Davey Smith, G. (2008) · Statistics in Medicine · doi:10.1002/sim.3034 · Cited by 4,618 · see citing works
Eslam, M., Newsome, P. N., Sarin, S. K., Anstee, Q. M., Targher, G., Romero-Gomez, M., Zelber-Sagi, S., Wai-Sun Wong, V., Dufour, J.-F., Schattenberg, J. M., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.039 · Cited by 4,472 · see citing works
Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians
Davies, N. M., Holmes, M. V., & Davey Smith, G. (2018) · BMJ · doi:10.1136/bmj.k601 · Cited by 4,404 · see citing works
Bedogni, G., Bellentani, S., Miglioli, L., Masutti, F., Passalacqua, M., Castiglione, A., & Tiribelli, C. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-33 · Cited by 3,054 · see citing works
Estes, C., Anstee, Q. M., Arias, M., Bantel, H., Bellentani, S., Caballería, J., Colombo, M., Craxı̀, A., Crespo, J., Day, C. P., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.05.036 · Cited by 1,986 · see citing works
Eddowes, P. J., Sasso, M., Allison, M., Tsochatzis, E. A., Anstee, Q. M., Sheridan, D. A., Guha, I. N., Cobbold, J., Deeks, J. J., Paradis, V., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.042 · Cited by 1,425 · see citing works
From NASH to HCC: current concepts and future challenges
Anstee, Q. M., Reeves, H. L., Kotsiliti, E., Govaere, O., & Heikenwalder, M. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0145-7 · Cited by 1,392 · see citing works
Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study
Park, J., Chen, M., Colombo, M., Roberts, L. R., Schwartz, M., Chen, P., Kudo, M., Johnson, P. J., Wagner, S., Orsini, L. S., et al. (2015) · Liver International · doi:10.1111/liv.12818 · Cited by 1,248 · see citing works
Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace
Baffy, G., Brunt, E. M., & Caldwell, S. H. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2011.10.027 · Cited by 856 · see citing works
A Protein-Truncating <i>HSD17B13</i> Variant and Protection from Chronic Liver Disease
Abul-Husn, N. S., Cheng, X., Li, A. H., Xin, Y., Schurmann, C., Stevis, P., Liu, Y., Kozlitina, J., Stender, S., Wood, G. C., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1712191 · Cited by 827 · see citing works
Younossi, Z. M., Otgonsuren, M., Henry, L., Venkatesan, C., Mishra, A., Erario, M., & Hunt, S. (2015) · Hepatology · doi:10.1002/hep.28123 · Cited by 802 · see citing works
Mancina, R. M., Dongiovanni, P., Petta, S., Pingitore, P., Meroni, M., Rametta, R., Borén, J., Montalcini, T., Pujia, A., Wiklund, O., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.01.032 · Cited by 676 · see citing works
Piscaglia, F., Svegliati‐Baroni, G., Barchetti, A., Pecorelli, A., Marinelli, S., Tiribelli, C., Bellentani, S., & on behalf of the HCC‐NAFLD Italian Study Group (2016) · Hepatology · doi:10.1002/hep.28368 · Cited by 604 · see citing works
Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team
Dyson, J., Jaques, B., Chattopadyhay, D., Lochan, R., Graham, J., Das, D., Aslam, T., Patanwala, I., Gaggar, S., Cole, M., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.08.011 · Cited by 603 · cited 1× · see citing works
“Upon confirmation by further studies, this relationship would suggest that approaches/drugs ai ming to reduce liver fat may contribute to prevent HCC.(4-7,31) As we exploited simple yet very robust PRS based o n a limited number of validated risk variants that can be used irrespective of the prese nce of liver disease…”
Liu, Y.-L., Patman, G. L., Leathart, J. B. S., Piguet, A.-C., Burt, A. D., Dufour, J.-F., Day, C. P., Daly, A. K., Reeves, H. L., & Anstee, Q. M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.02.030 · Cited by 549 · see citing works
Dongiovanni, P., Petta, S., Maglio, C., Fracanzani, A. L., Pipitone, R., Mozzi, E., Motta, B. M., Kaminska, D., Rametta, R., Grimaudo, S., et al. (2015) · Hepatology · doi:10.1002/hep.27490 · Cited by 533 · see citing works
Self-citationAdiposity amplifies the genetic risk of fatty liver disease conferred by multiple loci
Stender, S., Kozlitina, J., Nordestgaard, B. G., Tybjærg‐Hansen, A., Hobbs, H. H., & Cohen, J. C. (2017) · Nature Genetics · doi:10.1038/ng.3855 · Cited by 401 · see citing works
Update on NAFLD genetics: From new variants to the clinic
Trépo, E., & Valenti, L. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.02.020 · Cited by 393 · see citing works
Dongiovanni, P., Stender, S., Pietrelli, A., Mancina, R. M., Cespiati, A., Petta, S., Pelusi, S., Pingitore, P., Badiali, S., Maggioni, M., et al. (2018) · Journal of Internal Medicine · doi:10.1111/joim.12719 · Cited by 367 · see citing works
Loomba, R. S., Lim, J. K., Patton, H. M., & El‐Serag, H. B. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.12.053 · Cited by 360 · see citing works
Younossi, Z., & Henry, L. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.005 · Cited by 334 · cited 1× · see citing works
“Upon confirmation by further studies, this relationship would suggest that approaches/drugs ai ming to reduce liver fat may contribute to prevent HCC.(4-7,31) As we exploited simple yet very robust PRS based o n a limited number of validated risk variants that can be used irrespective of the prese nce of liver disease…”
MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
Donati, B., Dongiovanni, P., Romeo, S., Meroni, M., McCain, M. V., Miele, L., Petta, S., Maier, S., Rosso, C., Luca, L. D., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04991-0 · Cited by 262 · see citing works
Gellert‐Kristensen, H., Richardson, T. G., Smith, G. D., Nordestgaard, B. G., Tybjærg‐Hansen, A., & Stender, S. (2020) · Hepatology · doi:10.1002/hep.31238 · Cited by 255 · see citing works
Leveraging Human Genetics to Identify Potential New Treatments for Fatty Liver Disease
Romeo, S., Sanyal, A. J., & Valenti, L. V. C. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.12.002 · Cited by 203 · see citing works
Rare pathogenic variants predispose to hepatocellular carcinoma in nonalcoholic fatty liver disease
Pelusi, S., Baselli, G., Pietrelli, A., Dongiovanni, P., Donati, B., McCain, M. V., Meroni, M., Fracanzani, A. L., Romagnoli, R., Petta, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39998-2 · Cited by 125 · see citing works
Self-citationDegasperi, E., Galmozzi, E., Pelusi, S., D’Ambrosio, R., Soffredini, R., Borghi, M., Perbellini, R., Facchetti, F., Iavarone, M. A., Sangiovanni, A., et al. (2020) · Hepatology · doi:10.1002/hep.31500 · Cited by 67 · see citing works
Hepatic fat as clinical outcome and therapeutic target for nonalcoholic fatty liver disease
Pelusi, S., & Valenti, L. V. C. (2018) · Liver International · doi:10.1111/liv.13972 · Cited by 57 · see citing works
PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients
Dongiovanni, P., Meroni, M., Baselli, G., Mancina, R. M., Ruscica, M., Longo, M., Rametta, R., Cespiati, A., Pelusi, S., Ferri, N., et al. (2019) · Journal of Lipid Research · doi:10.1194/jlr.p090449 · Cited by 56 · see citing works
Uncovering the genetics of cirrhosis: New plots for the usual suspects
Valenti, L. V. C. (2020) · Liver International · doi:10.1111/liv.14333 · Cited by 8 · see citing works
Flagged first, then by citations
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Research works printed but not linked: 1
- [20]Dongiovanni P. Petta S. Maglio C. Fracanzani A. Pipitone R.M. Mozzi E. TM6SF2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease Hepatology 61 2015 506 514 25251399
Cited by
Sorted by citations
Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works
Global Epidemiology and Genetics of Hepatocellular Carcinoma
Toh, M. R., Wong, E. Y. T., Wong, S. H., Ng, A. W. T., Loo, L., Chow, P. K.-H., & Ngeow, J. Y. Y. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.01.033 · Cited by 600 · see citing works
(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 510 · see citing works
Nonalcoholic steatohepatitis-related hepatocellular carcinoma: pathogenesis and treatment
Llovet, J. M., Willoughby, C. E., Singal, A. G., Greten, T. F., Heikenwälder, M., El-Serag, H. B., Finn, R. S., & Friedman, S. L. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00754-7 · Cited by 354 · see citing works
Epidemiology and risk-stratification of NAFLD-associated HCC
Ioannou, G. N. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.08.012 · Cited by 361 · see citing works
Metabolic Dysfunction–Associated Steatotic Liver Disease
Targher, G., Valenti, L., & Byrne, C. D. (2025) · New England Journal of Medicine · doi:10.1056/nejmra2412865 · Cited by 325 · see citing works
Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors
Juanola, O., Martínez‐López, S., Francés, R., & Gómez‐Hurtado, I. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18105227 · Cited by 310 · see citing works
Metabolic dysfunction-associated steatotic liver disease in adults
Huang, D. Q., Wong, V. W., Rinella, M. E., Boursier, J., Lazarus, J. V., Yki‐Järvinen, H., & Loomba, R. S. (2025) · Nature Reviews Disease Primers · doi:10.1038/s41572-025-00599-1 · Cited by 336 · see citing works
Long, M. T., Noureddin, M., & Lim, J. K. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.06.023 · Cited by 299 · see citing works
Biomarkers for diagnosis and therapeutic options in hepatocellular carcinoma
Chan, Y.-T., Zhang, C., Wu, J., Lu, P., Xu, L., Yuan, H., Feng, Y., Chen, Z.-S., & Wang, N. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02101-z · Cited by 309 · see citing works
NAFLD‐related hepatocellular carcinoma: The growing challenge
Shah, P. A., Patil, R., & Harrison, S. A. (2022) · Hepatology · doi:10.1002/hep.32542 · Cited by 232 · see citing works
Impact of non-invasive biomarkers on hepatology practice: past, present and future
Anstee, Q. M., Castera, L., & Loomba, R. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.03.026 · Cited by 224 · see citing works
Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies
Parola, M., & Pinzani, M. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101231 · Cited by 226 · see citing works
Chen, Y., Du, X., Kuppa, A., Feitosa, M. F., Bielak, L. F., O’Connell, J. R., Musani, S. K., Guo, X., Kahali, B., Chen, V. L., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01497-6 · Cited by 215 · see citing works
The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease
Díaz, L. A., Arab, J. P., Louvet, A., Bataller, R., & Arrese, M. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00822-y · Cited by 207 · see citing works
Molecular mechanisms in MASLD/MASH-related HCC
Wang, X., Zhang, L., & Dong, B. (2024) · Hepatology · doi:10.1097/hep.0000000000000786 · Cited by 188 · see citing works
The first MASH drug therapy on the horizon: Current perspectives of resmetirom
Petta, S., Targher, G., Romeo, S., Pajvani, U. B., Zheng, M., Aghemo, A., & Valenti, L. (2024) · Liver international (Print) · doi:10.1111/liv.15930 · Cited by 174 · see citing works
Raverdy, V., Tavaglione, F., Chatelain, E., Lassailly, G., Vincentis, A. D., Gentilucci, U. V., Qadri, S. U., Caiazzo, R. J., Verkindt, H., Saponaro, C., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03283-1 · Cited by 176 · see citing works
Asian perspective on NAFLD-associated HCC
Yip, T. C., Lee, H. W., Chan, W., Wong, G. L., & Wong, V. W. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.09.024 · Cited by 159 · see citing works
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship
Karkucińska‐Więckowska, A., Simões, I. C. M., Kalinowski, P., Lebiedzińska, M., Zieniewicz, K., Milkiewicz, P., Górska‐Ponikowska, M., Pinton, P., Malik, A. N., Krawczyk, M. J., et al. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13622 · Cited by 165 · see citing works
De Vincentis, A., Tavaglione, F., Jamialahmadi, O., Picardi, A., Antonelli Incalzi, R., Valenti, L., Romeo, S., & Vespasiani-Gentilucci, U. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.05.056 · Cited by 158 · see citing works
Noninvasive assessment of liver fibrosis in NAFLD
Sanyal, A. J., Castera, L., & Wong, V. W.-S. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.03.042 · Cited by 157 · see citing works
Hepatocellular and extrahepatic cancer risk in people with non-alcoholic fatty liver disease
Thomas, J. A., Kendall, B. J., El‐Serag, H. B., Thrift, A. P., & Macdonald, G. A. (2024) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(23)00275-3 · Cited by 140 · see citing works
Risk stratification and early detection biomarkers for precision HCC screening
Lee, Y., Fujiwara, N., Yang, J. D., & Hoshida, Y. (2022) · Hepatology · doi:10.1002/hep.32779 · Cited by 128 · see citing works
Development and Validation of a Score for Fibrotic Nonalcoholic Steatohepatitis
Tavaglione, F., Jamialahmadi, O., Vincentis, A. D., Qadri, S. U., Mowlaei, M. E., Mancina, R. M., Ciociola, E., Carotti, S., Perrone, G., Bruni, V., et al. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2022.03.044 · Cited by 118 · see citing works
Longo, M., Meroni, M., Paolini, E., Erconi, V., Carli, F., Fortunato, F., Ronchi, D., Piciotti, R., Sabatini, S., Macchi, C., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.11.007 · Cited by 114 · see citing works
Metabolic dysfunction–associated fatty liver disease and the risk of 24 specific cancers
Liu, Z., Lin, C., Suo, C., Zhao, R., Li, J., Zhang, T., & Chen, X. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154955 · Cited by 110 · see citing works
Chen, V. L., Oliveri, A., Miller, M. J., Wijarnpreecha, K., Du, X., Chen, Y., Cushing, K. C., Lok, A. S., & Speliotes, E. K. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.01.040 · Cited by 108 · see citing works
Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL)
Huang, J.-K., & Lee, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084300 · Cited by 111 · see citing works
Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity
Arrese, M. A., Arab, J. P., Francisco Barrera, M., Kaufmann, B. K., Valenti, L. V. C., & Feldstein, A. E. (2021) · Seminars in Liver Disease · doi:10.1055/s-0041-1730927 · Cited by 104 · see citing works
Roeb, E., Canbay, A. E., Tacke, F., Bantel, H., Bojunga, J., de Laffolie, J., Demir, M., Denzer, U. W., Geier, A., Hofmann, W. P., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1880-2283 · Cited by 102 · see citing works
Rare ATG7 genetic variants predispose patients to severe fatty liver disease
Baselli, G. A., Jamialahmadi, O., Pelusi, S., Ciociola, E., Malvestiti, F., Saracino, M., Santoro, L., Cherubini, A., Dongiovanni, P., Maggioni, M., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.03.031 · Cited by 97 · see citing works
Singal, A. G., Sanduzzi‐Zamparelli, M., Nahon, P., Ronot, M., Hoshida, Y., Rich, N. E., Reig, M., Vilgrain, V., Marrero, J. A., Llovet, J. M., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.022 · Cited by 97 · see citing works
Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management
Lonardo, A., Arab, J. P., & Arrese, M. A. (2021) · Advances in Therapy · doi:10.1007/s12325-021-01690-1 · Cited by 93 · see citing works
Le, M. H., Le, D. M., Baez, T. C., Dang, H., Nguyen, V. H., Lee, K., Stave, C. D., Ito, T., Wu, Y., Yeo, Y. H., et al. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2023.0485 · Cited by 92 · see citing works
Therapeutic opportunities for the treatment of NASH with genetically validated targets
Lindén, D., & Romeo, S. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.05.007 · Cited by 87 · see citing works
Kendall, T. J., Ramos, M. J., Turner, F. S., Ramachandran, P., Minnier, J., McColgan, M. D., Alam, M., Ellis, H., Dunbar, D. R., Kohnen, G., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02602-2 · Cited by 90 · see citing works
A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers
Whitfield, J. B., Schwantes-An, T.-H. L., Darlay, R., Aithal, G. P., Atkinson, S. R., Bataller, R. A., Botwin, G., Chalasani, N., Cordell, H. J., Daly, A. K., et al. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.10.005 · Cited by 87 · see citing works
Nahon, P., Bamba‐Funck, J., Layese, R., Trépo, E., Zucman‐Rossi, J., Cagnot, C., Ganne‐Carrié, N., Chaffaut, C., Guyot, E., Ziol, M., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.11.003 · Cited by 84 · see citing works
Romeo, S., Vidal‐Puig, A., Husain, M., Ahima, R. S., Arca, M., Bhatt, D. L., Diehl, A. M., Fontana, L., Foo, R., Frühbeck, G., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf314 · Cited by 91 · see citing works
Genetics of Metabolic Dysfunction-associated Steatotic Liver Disease: The State of the Art Update
Sookoian, S. C., Rotman, Y., & Valenti, L. V. C. (2024) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2024.05.052 · Cited by 81 · see citing works
Pοlyzos, S. A., Chrysavgis, L., Vachliotis, I. D., Chartampilas, E., & Cholongitas, Ε. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.04.010 · Cited by 81 · see citing works
Performance of routine risk scores for predicting cirrhosis-related morbidity in the community
Innes, H. A., Morling, J. R., Buch, S., Hamill, V., Stickel, F., & Guha, I. N. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.02.022 · Cited by 77 · see citing works
Tamaki, N., Ahlholm, N., Luukkonen, P. K., Porthan, K., Sharpton, S. R., Ajmera, V., Kono, Y., Dave, S., Ahmed, A., Sundaram, V., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci162513 · Cited by 69 · see citing works
Genetics Is of the Essence to Face NAFLD
Meroni, M., Longo, M., Tria, G., & Dongiovanni, P. (2021) · Biomedicines · doi:10.3390/biomedicines9101359 · Cited by 68 · see citing works
Ahmed, A., Cule, M., Bell, J. D., Sattar, N. A., & Yaghootkar, H. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.06.030 · Cited by 63 · see citing works
Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease
Qadri, S. U., Ahlholm, N., Lønsmann, I., Pellegrini, P., Poikola, A., Luukkonen, P. K., Porthan, K., Juuti, A., Sammalkorpi, H. E., Penttilä, A. K., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab933 · Cited by 63 · see citing works
Gutiérrez‐Cuevas, J., Lucano‐Landeros, S., López-Cifuentes, D., Santos, A., & Armendáriz‐Borunda, J. (2022) · Cancers · doi:10.3390/cancers15010023 · Cited by 62 · see citing works
Remodeling of Mitochondrial Plasticity: The Key Switch from NAFLD/NASH to HCC
Longo, M., Paolini, E., Meroni, M., & Dongiovanni, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084173 · Cited by 61 · see citing works
Amangurbanova, M., Huang, D. Q., & Loomba, R. S. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17292 · Cited by 62 · see citing works
Talamantes, S., Lisjak, M., Gilglioni, E. H., Llamoza-Torres, C. J., Ramos‐Molina, B., & Gurzov, E. N. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100811 · Cited by 60 · see citing works
NAFLD-Associated HCC: Progress and Opportunities
Geh, D., Anstee, Q. M., & Reeves, H. L. (2021) · Journal of Hepatocellular Carcinoma · doi:10.2147/jhc.s272213 · Cited by 61 · see citing works
Motta, B. M., Masarone, M., Torre, P., & Persico, M. (2023) · Cancers · doi:10.3390/cancers15225458 · Cited by 60 · see citing works
Genetic predisposition similarities between NASH and ASH: Identification of new therapeutic targets
Bianco, C., Casirati, E., Malvestiti, F., & Valenti, L. V. C. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100284 · Cited by 50 · see citing works
Caviglia, G. P., Armandi, A., Rosso, C., Gaia, S., Aneli, S., Rolle, E., Abate, M. L., Olivero, A., Nicolosi, A., Guariglia, M., et al. (2021) · Cancers · doi:10.3390/cancers13102305 · Cited by 48 · see citing works
Hepatocellular Carcinoma in Metabolic Dysfunction-Associated Steatotic Liver Disease
Rodríguez, L. A., Schmittdiel, J. A., Liu, L., Macdonald, B. A., Balasubramanian, S., Chai, K. P., Seo, S., Mukhtar, N. A., Levin, T. R., & Saxena, V. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.21019 · Cited by 48 · see citing works
Caon, E., Martins, M. C., Hodgetts, H., Blanken, L., Vilia, M., Levi, A., Thanapirom, K., Al-Akkad, W., Abu-Hanna, J., Baselli, G., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.01.032 · Cited by 45 · see citing works
Epidemiology, pathophysiology and clinical aspects of Hepatocellular Carcinoma in MAFLD patients
Argenziano, M. E., Kim, M. N., Montori, M., Bucchianico, A. D., Balducci, D., Ahn, S. H., & Svegliati‐Baroni, G. (2024) · Hepatology International · doi:10.1007/s12072-024-10692-4 · Cited by 50 · see citing works
Contribution of a genetic risk score to ethnic differences in fatty liver disease
Kubiliun, M. J., Cohen, J. C., Hobbs, H. H., & Kozlitina, J. (2022) · Liver International · doi:10.1111/liv.15322 · Cited by 45 · see citing works
MAFLD: an optimal framework for understanding liver cancer phenotypes
Crane, H., Gofton, C., Sharma, A., & George, J. (2023) · Journal of Gastroenterology · doi:10.1007/s00535-023-02021-7 · Cited by 45 · see citing works
Tesfai, K., Pace, J., El-Newihi, N., Martinez, M. E., Tincopa, M. A., & Loomba, R. S. (2024) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2024.06.038 · Cited by 45 · see citing works
Chen, V. L., Kuppa, A., Oliveri, A., Chen, Y., Ponnandy, P., Patel, P. B., Palmer, N. D., & Speliotes, E. K. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186424 · Cited by 45 · see citing works
The contribution of genetics and epigenetics to MAFLD susceptibility
Moretti, V., Romeo, S., & Valenti, L. V. C. (2024) · Hepatology International · doi:10.1007/s12072-024-10667-5 · Cited by 43 · see citing works
Armandi, A., Rosso, C., Caviglia, G. P., & Bugianesi, E. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156080 · Cited by 43 · see citing works
Carbone, F., Després, J., Ioannidis, J. P. A., Neeland, I. J., Garruti, G., Busetto, L., Liberale, L., Ministrini, S., Vilahur, G., Schindler, T. H., et al. (2025) · European Journal of Clinical Investigation · doi:10.1111/eci.70059 · Cited by 45 · see citing works
Chen, S., Pang, J., Huang, R., Xue, H., & Chen, X. (2023) · Hepatology International · doi:10.1007/s12072-023-10486-0 · Cited by 41 · see citing works
Insulin resistance is an integral feature of MASLD even in the presence of PNPLA3 variants
Bril, F., Kalavalapalli, S., Lomonaco, R., Frye, R. F., Leiva, E. G., & Cusi, K. J. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101092 · Cited by 41 · see citing works
Genetic Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease
Pei, Y., & Goh, G. B. (2025) · Gut and Liver · doi:10.5009/gnl240407 · Cited by 41 · see citing works
High inherited risk predicts age-associated increases in fibrosis in patients with MASLD
Díaz, L. A., Alazawi, W., Agrawal, S., Arab, J. P., Arrese, M. A., Idalsoaga, F. J., Barreyro, F. J., Gadano, A. C., Marciano, S., Morales, J. M., et al. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.04.035 · Cited by 43 · see citing works
Hepatocellular Carcinoma in Non-alcoholic Fatty Liver Disease: Current Progresses and Challenges
Teng, Y., Xie, S., Guo, P., Deng, Z.-J., Zhang, Z., Gao, W., Zhang, W.-G., & Zhong, J.-H. (2022) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2021.00586 · Cited by 36 · see citing works
Precision medicine and nucleotide-based therapeutics to treat steatotic liver disease
Caddeo, A. M., & Romeo, S. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0438 · Cited by 41 · see citing works
Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD
Petta, S., Armandi, A., & Bugianesi, E. (2024) · Liver International · doi:10.1111/liv.16133 · Cited by 38 · see citing works
The burden of liver disease in Latin America
Díaz, L. A., Villota‐Rivas, M., Francisco Barrera, M., Lazarus, J. V., & Arrese, M. A. (2023) · Annals of Hepatology · doi:10.1016/j.aohep.2023.101175 · Cited by 37 · see citing works
Lin, H., Li, G., Delamarre, A., Ahn, S. H., Zhang, X., Kim, B. K., Liang, L. Y., Lee, H. W., Wong, G. L., Yuen, P. C., et al. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.11.005 · Cited by 37 · see citing works
Long‐term hepatic safety of lomitapide in homozygous familial hypercholesterolaemia
Larrey, D. G., D’Erasmo, L., O’Brien, S. L., Arca, M., & the Italian Working Group on Lomitapide (2022) · Liver International · doi:10.1111/liv.15497 · Cited by 36 · see citing works
Advances in the genetics of nonalcoholic fatty liver disease
Ajmera, V. H., & Loomba, R. S. (2023) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000927 · Cited by 36 · see citing works
A PDCD1 Role in the Genetic Predisposition to NAFLD-HCC?
Eldafashi, N., Darlay, R., Shukla, R., McCain, M. V., Watson, R., Liu, Y. L., McStraw, N. M., Fathy, M., Fawzy, M. A., Zaki, M. Y. W., et al. (2021) · Cancers · doi:10.3390/cancers13061412 · Cited by 36 · see citing works
Armandi, A., & Bugianesi, E. (2021) · Liver International · doi:10.1111/liv.14910 · Cited by 36 · see citing works
Seko, Y., Yamaguchi, K., Shima, T., Iwaki, M., Takahashi, H., Kawanaka, M., Tanaka, S., Mitsumoto, Y., Yoneda, M., Nakajima, A., et al. (2023) · Liver International · doi:10.1111/liv.15678 · Cited by 35 · see citing works
Guo, C., Liu, Z., Fan, H. X., Wang, H., Zhang, X., Zhao, S., Li, Y., Han, X., Wang, T., Chen, X., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000879 · Cited by 35 · see citing works
Teng, P., Huang, D. Q., Lin, T.-Y., Noureddin, M., & Yang, J. D. (2022) · Gut and Liver · doi:10.5009/gnl220357 · Cited by 33 · see citing works
Liu, Z., Huang, H., Xie, J., Xu, Y., & Xu, C. (2024) · Nature Communications · doi:10.1038/s41467-024-47960-8 · Cited by 32 · see citing works
Wang, Y., Song, S. J., Jiang, Y., Lai, J. C., Wong, G. L., Wong, V. W., & Yip, T. C. (2024) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2024.0246 · Cited by 32 · see citing works
Dallio, M., Romeo, M., Gravina, A. G., Masarone, M., Larussa, T., Abenavoli, L., Persico, M., Loguercio, C., & Federico, A. (2021) · Nutrients · doi:10.3390/nu13051679 · Cited by 32 · see citing works
The Emerging Factors and Treatment Options for NAFLD-Related Hepatocellular Carcinoma
Zhang, C., & Yang, M. J. (2021) · Cancers · doi:10.3390/cancers13153740 · Cited by 34 · see citing works
Varadharajan, V., Massey, W. J., & Brown, J. M. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100234 · Cited by 32 · see citing works
Deciphering the role of aberrant DNA methylation in NAFLD and NASH
Vachher, M., Bansal, S., Kumar, B., Yadav, S., & Burman, A. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11119 · Cited by 31 · see citing works
Distinctive features of hepatocellular carcinoma in non-alcoholic fatty liver disease
Valenti, L. V. C., Pedica, F., & Colombo, M. (2021) · Digestive and Liver Disease · doi:10.1016/j.dld.2021.06.023 · Cited by 31 · see citing works
NAFLD polygenic risk score and risk of hepatocellular carcinoma in an East Asian population
Thomas, C. E., Diergaarde, B. B., Kuipers, A. L., Adibi, J. J., Luu, H. N., Chang, X., Dorajoo, R., Heng, C., Khor, C. C., Wang, R., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1976 · Cited by 31 · see citing works
Yu, J., Li, D., You, Y., Yu, J., Jiang, W., Liu, Y., Zeng, R., Wan, Z., Yi, L., & Liao, X. (2023) · BMC Medicine · doi:10.1186/s12916-023-03080-6 · Cited by 30 · see citing works
Differences between hepatocellular carcinoma caused by alcohol and other aetiologies
Ganne‐Carrié, N., & Nahon, P. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.12.030 · Cited by 34 · see citing works
Bergamot Polyphenol Extract Reduces Hepatocyte Neutral Fat by Increasing Beta-Oxidation
Mirarchi, A., Mare, R., Musolino, V., Nucera, S., Mollace, V., Pujia, A., Montalcini, T., Romeo, S., & Maurotti, S. (2022) · Nutrients · doi:10.3390/nu14163434 · Cited by 30 · see citing works
Hepatocellular carcinoma surveillance in patients with non-alcoholic fatty liver disease
Dahan, K. S. E., Daher, D., & Singal, A. G. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0247 · Cited by 30 · see citing works
Authors, & Collaborators: (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1880-2388 · Cited by 30 · see citing works
Männistö, V., Salomaa, V. V., Färkkilä, M. A., Jula, A., Männistö, S., Erlund, I., Sundvall, J., Lundqvist, A., Perola, M., & Åberg, F. O. (2021) · Liver International · doi:10.1111/liv.15004 · Cited by 29 · see citing works
Non-alcoholic steatohepatitis and risk of hepatocellular carcinoma
Rios, R. S., Zheng, K. I., & Zheng, M.-H. (2021) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001888 · Cited by 29 · see citing works
Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis
Tovo, C. V., de Mattos, Â. Z., Coral, G. P., SARTORI, G. D. P., Nogueira, L. V., Both, G. T., Villela‐Nogueira, C. A., & de Mattos, Â. A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i2.343 · Cited by 32 · see citing works
Genetic Polymorphisms and Diversity in Nonalcoholic Fatty Liver Disease (NAFLD): A Mini Review
Sulaiman, S. A., Dorairaj, V., & Adrus, M. N. H. (2022) · Biomedicines · doi:10.3390/biomedicines11010106 · Cited by 29 · see citing works
Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC
Dongiovanni, P., Meroni, M., Longo, M., Fargion, S. R., & Fracanzani, A. L. (2021) · Biomedicines · doi:10.3390/biomedicines9111524 · Cited by 27 · see citing works
Valenti, L. V. C., Tripodi, A., Mura, V. L., Pelusi, S., Bianco, C., Scalambrino, E., Margarita, S., Malvestiti, F., Ronzoni, L., Clerici, M., et al. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100598 · Cited by 27 · see citing works
- Authors
- Bianco, C., Jamialahmadi, O., Pelusi, S., Baselli, G., Dongiovanni, P., Zanoni, I., Santoro, L., Maier, S., Liguori, A., Meroni, M., Borroni, V., D’Ambrosio, R., Spagnuolo, R., Alisi, A., Federico, A., Bugianesi, E., Petta, S., Miele, L., Vespasiani-Gentilucci, U., Anstee, Q. M., Stickel, F., Hampe, J., Fischer, J., Berg, T., Fracanzani, A. L., Soardo, G., Reeves, H., Prati, D., Romeo, S., & Valenti, L.
- Affiliations
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Sahlgrenska University Hospital (SE)
- University of Milan (IT)
- University of Udine (IT)
- Agostino Gemelli University Polyclinic (IT)
- Bambino Gesù Children's Hospital (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- University of Palermo (IT)
- Newcastle upon Tyne Hospitals NHS Foundation Trust (GB)
- University Hospital Zurich (CH)
- University Hospital Carl Gustav Carus (DE)
- University Hospital Leipzig (DE)
- Corresponding author
- Romeo, Stefano
- Valenti, Luca
- ORCID
- Bianco, Cristiana
- Jamialahmadi, Oveis
- Pelusi, Serena
- Baselli, Guido
- Dongiovanni, Paola
- Maier, Silvia
- Liguori, Antonio
- Meroni, Marica
- Borroni, Vittorio
- D’Ambrosio, Roberta
- Spagnuolo, Rocco
- Alisi, Anna
- Federico, Alessandro
- Bugianesi, Elisabetta
- Petta, Salvatore
- Miele, Luca
- Anstee, Quentin M.
- Stickel, Felix
- Hampe, Jochen
- Fischer, Janett
- Berg, Thomas
- Fracanzani, Anna Ludovica
- Soardo, Giorgio
- Reeves, Helen
- Prati, Daniele
- Romeo, Stefano
- Valenti, Luca
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 74
- Issue
- 4
- Pages
- 775-782
- ISSN
- 0168-8278 (ISSN-L)
- PMC
- PMC7987554
- OpenAlex
- W3106622583
- Cited by
- 385
- References
- 37
- Citations by year
- 2026: 60 · 2025: 60 · 2024: 68 · 2023: 80 · 2022: 64 · 2021: 52
- FWCI
- 35.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Hepatology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Institutional Research Information System (University of Udine) (submittedVersion, cc-by-nc-nd)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- Newcastle University ePrints (Newcastle Univesity) (cc-by-nc-nd)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030_169196)
- Marianne and Marcus Wallenberg Foundation (KAW 2017.0203)
- Knut och Alice Wallenbergs Stiftelse
- Swiss Foundation for Alcohol Research
- AbbVie
- Akebia Therapeutics
- Amgen
- Novo Nordisk
- Novo Nordisk Fonden (DIA 2017-205, 9321-430)
- Hjärt-Lungfonden (20120533)
- European Research Council
- Seventh Framework Programme
- Diabetesförbundet
- Sanofi
- Pfizer
- Celgene
- Vetenskapsrådet (2016-01527)
- European Commission
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (RC100017A)
- Associazione Italiana per la Ricerca sul Cancro (16888)
- Ministero della Salute (RF-2016-02364358)
- Cancer Research UK (C18342/A23390, C9380/A18084, C9380/A26813)
- Gilead Sciences
- AstraZeneca
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- hepatocellular carcinoma, non-alcoholic fatty liver disease, polygenic risk score, HCC risk stratification, hepatic steatosis, liver fibrosis, PNPLA3, TM6SF2, GCKR, MBOAT7, HSD17B13, genetic susceptibility, liver cirrhosis, HCC detection, UK Biobank
- MeSH terms
- Mediation Analysis, Cross-Sectional Studies, Europe, Female, Carcinoma, Hepatocellular, Humans, Liver, Liver Cirrhosis, Liver Neoplasms, Male, Middle Aged, Predictive Value of Tests, Prognosis, Risk Factors, Risk Assessment, Genetic Predisposition to Disease, Multifactorial Inheritance, Adiposity, Non-alcoholic Fatty Liver Disease
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