24-Norursodeoxycholic acid reshapes immunometabolism in CD8(+) T cells and alleviates hepatic inflammation
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Abstract
Abstract Background & Aims 24-NorUrsodeoxycholic acid (NorUDCA) is novel therapy for immune-mediated liver diseases such as primary sclerosing cholangitis (PSC) where dysregulated T cells including CD8 + T cells cause liver immunopathology. We hypothesized that NorUDCA may directly modulate CD8 + T cell effector function thus contributing to its therapeutic efficacy independent of anti-cholestatic effects. Methods NorUDCA effects on CD8 + T cell function in vivo were investigated in a hepatic injury model system induced by excessive CD8 + T cell immune response upon non-cytolytic lymphocytic choriomeningitis virus (LCMV) infection. Mechanistic studies included molecular and biochemical approaches, flow cytometry and metabolic assays in mouse CD8 + T cells in vitro . Mass spectrometry (MS) was used to identify potential targets modulated by NorUDCA in CD8 + T cells. NorUDCA signaling effects observed in murine systems were validated in peripheral T cells from healthy volunteers and PSC patients. Results In vivo NorUDCA ameliorated hepatic injury and systemic inflammation upon LCMV infection. Mechanistically, NorUDCA demonstrated a strong immunomodulatory efficacy in CD8 + T cells affecting lymphoblastogenesis, mTORC1 signaling and glycolysis of CD8 + T cells. With MS, we identified that NorUDCA regulates CD8 + T cells via targeting mTORC1. NorUDCA’s impact on mTORC1 signaling was further confirmed in circulating human CD8 + T cells. Conclusions NorUDCA possesses a yet-unrecognized direct modulatory potency on CD8 + T cells and attenuates excessive CD8 + T cell hepatic immunopathology. These findings may be relevant for treatment of immune-mediated liver diseases such as PSC and beyond.
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Norucholic acid has shown anticholestatic, anti-inflammatory and anti-fibrotic properties in preclinical models and is being tested for MASH with initial results showing improvement in ALT and liver steatosis.
“A synthetic UDCA derivative, 24norursodeoxycholic acid (norucholic acid), has shown anticholestatic, anti-in fl ammatory and anti- fi brotic properties in preclinical models 376 and is being tested for MASH with initial results showing improvement in ALT and liver steatosis.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [376]
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Cites
mTOR Signaling in Growth, Metabolism, and Disease
Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works
mTOR Signaling in Growth, Metabolism, and Disease.
Saxton, R., & Sabatini, D. (2017) · Cell · doi:10.1016/j.cell.2017.03.035 · Cited by 3,889 · see citing works
mTOR regulates memory CD8 T-cell differentiation
Araki, K., Turner, A. P., Shaffer, V. O., Gangappa, S., Keller, S. A., Bachmann, M. F., Larsen, C. P., & Ahmed, R. (2009) · Nature · doi:10.1038/nature08155 · Cited by 1,575 · see citing works
Fueling Immunity: Insights into Metabolism and Lymphocyte Function
Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works
Bengsch, B., Johnson, A. L., Kurachi, M., Odorizzi, P. M., Pauken, K. E., Attanasio, J., Stelekati, E., McLane, L. M., Paley, M. A., Delgoffe, G. M., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.07.008 · Cited by 868 · see citing works
Primary sclerosing cholangitis – a comprehensive review
Karlsen, T. H., Folseraas, T., Thorburn, D., & Vesterhus, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.07.022 · Cited by 868 · see citing works
Immunoregulatory functions of mTOR inhibition
Thomson, A. W., Turnquist, H. R., & Raimondi, G. (2009) · Nature reviews. Immunology · doi:10.1038/nri2546 · Cited by 849 · see citing works
Maini, M. K., Boni, C., Lee, C. K., Larrubia, J. R., Reignat, S., Ogg, G. S., King, A. S., Herberg, J. A., Gilson, R. J. C., Alisa, A., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1269 · Cited by 800 · see citing works
Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K., & Cantrell, D. A. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112607 · Cited by 596 · see citing works
Metabolic switching and fuel choice during T‐cell differentiation and memory development
van der Windt, G. J. W., & Pearce, E. L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01150.x · Cited by 563 · see citing works
New paradigms in the treatment of hepatic cholestasis: from UDCA to FXR, PXR and beyond
Beuers, U., Trauner, M., Jansen, P., & Poupon, R. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.023 · Cited by 537 · see citing works
Self-citationFickert, P., Fuchsbichler, A., Wagner, M., Zollner, G., Kaser, A., Tilg, H., Krause, R. G. E., Lammert, F., Langner, C., Zatloukal, K., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.009 · Cited by 468 · see citing works
mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
Pollizzi, K. N., Patel, C. H., Sun, I., Oh, M. H., Waickman, A. T., Wen, J., Delgoffe, G. M., & Powell, J. D. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77746 · Cited by 409 · see citing works
Tan, H., Yang, K., Li, Y., Shaw, T. I., Wang, Y., Blanco, D. B., Wang, X., Cho, J.-H., Wang, H., Rankin, S., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.010 · Cited by 372 · see citing works
Fickert, P., Wagner, M., Marschall, H., Fuchsbichler, A., Zollner, G., Tsybrovskyy, O., Zatloukal, K., Liu, J., Waalkes, M. P., Cover, C., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.018 · Cited by 301 · see citing works
norUrsodeoxycholic acid improves cholestasis in primary sclerosing cholangitis
Fickert, P., Hirschfield, G. M., Denk, G., Marschall, H.-U., Altorjay, I., Färkkilä, M., Schramm, C., Spengler, U., Chapman, R., Bergquist, A., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.009 · Cited by 297 · see citing works
Yoon, Y. B., Hagey, L. R., Hofmann, A. F., Gurantz, D., Michelotti, E. L., & Steinbagh, J. H. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90859-0 · Cited by 248 · see citing works
Zinkernagel, R. M., Haenseler, E., Leist, T., Cerny, A., Hengartner, H., & Althage, A. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.164.4.1075 · Cited by 208 · see citing works
Halilbasic, E., Fiorotto, R., Fickert, P., Marschall, H., Moustafa, T., Spirlı̀, C., Fuchsbichler, A., Gumhold, J., Silbert, D., Zatloukal, K., et al. (2009) · Hepatology · doi:10.1002/hep.22891 · Cited by 157 · see citing works
The immunobiology of mTOR in autoimmunity
Suto, T., & Karonitsch, T. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102373 · Cited by 149 · see citing works
Bartholdy, C., Christensen, J. P., Wodarz, D., & Thomsen, A. R. (2000) · Journal of Virology · doi:10.1128/jvi.74.22.10304-10311.2000 · Cited by 136 · see citing works
Yoon, M., Sun, Y., Arauz, E. J., Jiang, Y., & Chen, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.262816 · Cited by 134 · see citing works
Lercher, A., Bhattacharya, A., Popa, A., Caldera, M., Schlapansky, M. F., Baazim, H., Agerer, B., Gürtl, B., Kosack, L., Májek, P., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.10.014 · Cited by 120 · see citing works
Novel biotransformation and physiological properties of norursodeoxycholic acid in humans†‡
Hofmann, A. F., Zakko, S. F., Lira, M., Clerici, C., Hagey, L. R., Lambert, K. K., Steinbach, J. H., Schteingart, C. D., Olinga, P., & Groothuis, G. M. M. (2005) · Hepatology · doi:10.1002/hep.20943 · Cited by 110 · see citing works
Cornberg, M., Kenney, L. L., Chen, A. T., Waggoner, S. N., Kim, S.-K., Dienes, H. P., Welsh, R. M., & Selin, L. K. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00475 · Cited by 109 · see citing works
Liaskou, E., Jeffery, L. E., Trivedi, P. J., Reynolds, G. M., Suresh, S., Bruns, T., Adams, D., Sansom, D. M., & Hirschfield, G. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.04.003 · Cited by 104 · see citing works
CD8+ T cells induce cachexia during chronic viral infection
Baazim, H., Schweiger, M., Moschinger, M., Xu, H. C., Scherer, T., Popa, A., Gallage, S., Ali, A., Khamina, K., Kosack, L., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0397-y · Cited by 89 · see citing works
Re-examining the Nature and Function of Self-Reactive T cells
Richards, D. M., Kyewski, B., & Feuerer, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2015.12.005 · Cited by 80 · see citing works
Twenty-Year Comparative Analysis of Patients With Autoimmune Liver Diseases on Transplant Waitlists
Webb, G. J., Rana, A. A., Hodson, J. A., Akhtar, M. Z., Ferguson, J., Neuberger, J., Vierling, J. M., & Hirschfield, G. M. (2017) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.09.062 · Cited by 61 · see citing works
Ravichandran, G., Neumann, K., Berkhout, L. K., Weidemann, S. A., Langeneckert, A. E., Schwinge, D., Poch, T., Huber, S., Schiller, B., Hess, L. U., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.05.023 · Cited by 56 · see citing works
Heydtmann, M., Hardie, D. L., Shields, P. L., Faint, J., Buckley, C. D., Campbell, J. J., Salmon, M., & Adams, D. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.729 · Cited by 53 · see citing works
Ohradanova‐Repic, A., Machacek, C., Charvet, C., Lager, F., Roux, D. L., Platzer, R., Leksa, V., Mitulović, G., Burkard, T. R., Zlabinger, G. J., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00852 · Cited by 52 · see citing works
Pollizzi, K. N., Waickman, A. T., Patel, C. H., Sun, I., & Powell, J. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121710 · Cited by 48 · see citing works
Enhancing immunity prevents virus‐induced T‐cell‐mediated immunopathology in B cell‐deficient mice
Straub, T., & Pircher, H. (2019) · European Journal of Immunology · doi:10.1002/eji.201847962 · Cited by 7 · see citing works
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Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works
Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis
Wang, J., Zhu, N., Su, L., Gao, Y., & Yang, R. (2023) · Cells · doi:10.3390/cells12050793 · Cited by 624 · see citing works
(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 510 · see citing works
Bile acid metabolism and signalling in liver disease
Fuchs, C. D., Simbrunner, B., Baumgartner, M., Campbell, C., Reiberger, T., & Trauner, M. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.09.032 · Cited by 246 · see citing works
Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options
Grander, C., Grabherr, F., & Tilg, H. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad095 · Cited by 216 · see citing works
Effects of altered glycolysis levels on CD8+ T cell activation and function
Cao, J., Liao, S., Zeng, F., Liao, Q., Luo, G., & Zhou, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05937-3 · Cited by 164 · see citing works
Gut microbiota derived bile acid metabolites maintain the homeostasis of gut and systemic immunity
Su, L., Gao, Y., & Yang, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127743 · Cited by 167 · see citing works
Bile acids and their receptors: modulators and therapeutic targets in liver inflammation
Bertolini, A., Fiorotto, R., & Strazzabosco, M. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00935-7 · Cited by 142 · see citing works
Immunology of bile acids regulated receptors
Fiorucci, S., Marchianò, S., Urbani, G., Giorgio, C. D., Distrutti, E., Zampella, A., & Biagioli, M. (2024) · Progress in Lipid Research · doi:10.1016/j.plipres.2024.101291 · Cited by 84 · see citing works
Bile Acid Signaling in Metabolic and Inflammatory Diseases and Drug Development
Li, T., & Chiang, J. Y. L. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.124.000978 · Cited by 83 · see citing works
Primary sclerosing cholangitis
Manns, M. P., Bergquist, A. M., Karlsen, T. H., Levy, C., Muir, A. J., Ponsioen, C. Y., Trauner, M., Wong, G. L., & Younossi, Z. M. (2025) · Nature Reviews Disease Primers · doi:10.1038/s41572-025-00600-x · Cited by 71 · see citing works
NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis
Huang, B., Lyu, Z., Qian, Q., Chen, Y., Zhang, J., Li, B., Li, Y., Liang, J., Liu, Q., Li, Y., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.06.014 · Cited by 60 · see citing works
Recent Advances in the Management of Primary Sclerosing Cholangitis
Assis, D. N., & Bowlus, C. L. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.04.004 · Cited by 55 · see citing works
Nevens, F., Trauner, M. A., & Manns, M. P. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.10.007 · Cited by 51 · see citing works
The history and future of bile acid therapies
Beuers, U. H., Bañales, J. M., Karpen, S. J., Keitel, V., Williamson, C., & Trauner, M. (2025) · Journal of Hepatology · doi:10.1016/j.jhep.2025.06.010 · Cited by 43 · see citing works
Gupta, V., Sehrawat, T. S., Pinzani, M., & Strazzabosco, M. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.07.044 · Cited by 35 · see citing works
Gut microbiota: A double-edged sword in immune checkpoint blockade immunotherapy against tumors
Wang, J., Zhu, N., Su, L., & Yang, R. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216582 · Cited by 32 · see citing works
Therapeutic modulation of the liver immune microenvironment
Tilg, H., Adolph, T. E., & Tacke, F. (2023) · Hepatology · doi:10.1097/hep.0000000000000386 · Cited by 31 · see citing works
Cheng, W., Li, F., & Yang, R. (2024) · Gastro Hep Advances · doi:10.1016/j.gastha.2024.05.012 · Cited by 28 · see citing works
Trauner, M. A., Karpen, S. J., & Dawson, P. A. (2025) · Hepatology · doi:10.1097/hep.0000000000001438 · Cited by 26 · see citing works
Primary Biliary Cholangitis and Primary Sclerosing Cholangitis Therapy Landscape
Bhushan, S. R., Sohal, A., & Kowdley, K. V. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000003174 · Cited by 29 · see citing works
Zhu, C., Boucheron, N., Al-Rubaye, O., Chung, B. K., Thorbjørnsen, L. W., Köcher, T., Schuster, M., Claudel, T., Halilbasic, E., Kunczer, V., et al. (2025) · Gut · doi:10.1136/gutjnl-2024-333297 · Cited by 25 · see citing works
Ba, T., Zhao, D., Chen, Y., Zeng, C., Zhang, C., Niu, S., & Dai, H. (2022) · Nutrients · doi:10.3390/nu14214549 · Cited by 25 · see citing works
Cellular Interactions and Crosstalk Facilitating Biliary Fibrosis in Cholestasis
Ceci, L., Gaudio, E., & Kennedy, L. L. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.01.005 · Cited by 25 · see citing works
Fiorucci, S., Urbani, G., Giorgio, C. D., Biagioli, M., & Distrutti, E. (2024) · Cells · doi:10.3390/cells13191650 · Cited by 22 · see citing works
Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy
Liu, Y., Li, F., Wang, J., & Yang, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1518779 · Cited by 21 · see citing works
Macrophages in cholangiopathies
Bruneau, A., Guillot, A., & Tacke, F. (2021) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000814 · Cited by 18 · see citing works
Kellerer, M., Javed, S., Casar, C., Will, N., Berkhout, L. K., Schwinge, D., Krebs, C. F., Schramm, C., Neumann, K., & Tiegs, G. (2024) · Hepatology · doi:10.1097/hep.0000000000000830 · Cited by 17 · see citing works
Xu, Y., Zhao, Z., Yan, E. P., Lian, Z., & Zhang, W. (2023) · Medicine Advances · doi:10.1002/med4.23 · Cited by 18 · see citing works
Bile acids attenuate hepatic inflammation during ischemia/reperfusion injury
Huang, K., Wang, C., Mei, B., Li, J., Ren, T., Zhan, H., Zhang, Y., Zhang, B., Lv, X., Zhang, Q., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101101 · Cited by 16 · see citing works
Targeting bile salt homeostasis in biliary diseases
Trampert, D. C., Kunst, R. F., & van de Graaf, S. F. J. (2024) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000997 · Cited by 11 · see citing works
The Role of Gut Microbiota in Neuromyelitis Optica Spectrum Disorder
Yao, S.-Q., Yang, X.-Y., Cen, L.-P., & Tan, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063179 · Cited by 11 · see citing works
Truong, J. K., Li, J., Li, Q., Pachura, K. J., Rao, A., Gumber, S., Fuchs, C. D., Feranchak, A. P., Karpen, S. J., Trauner, M. A., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.149360 · Cited by 11 · see citing works
Wang, W., Lian, H., Liang, Y., Ye, Y., Tam, P. K. H., & Chen, Y. (2024) · Cells · doi:10.3390/cells13231997 · Cited by 11 · see citing works
Immunobiology of bile and cholangiocytes
Yang, L., Leung, P. S. C., Zhang, W., Zhang, S., Liu, Z., Kurth, M. J., Patterson, A. D., Gershwin, M. E., & Song, J. (2025) · Journal of Autoimmunity · doi:10.1016/j.jaut.2025.103376 · Cited by 10 · see citing works
Grander, C., Meyer, M., Steinacher, D., Claudel, T., Hausmann, B., Pjevac, P., Grabherr, F., Oberhuber, G., Grander, M., Brigo, N., et al. (2023) · JHEP Reports · doi:10.1016/j.jhepr.2023.100872 · Cited by 9 · see citing works
Avcioglu, S. Y., & Berkel, Ç. (2025) · Apmis · doi:10.1111/apm.70066 · Cited by 6 · see citing works
An update on novel pharmacological agents for primary sclerosing cholangitis
Gallo, C., Howardson, B. O., Cristoferi, L., Carbone, M., Gershwin, M. E., & Invernizzi, P. (2022) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2022.2030707 · Cited by 6 · see citing works
Yuan, Y., Tian, Y., Zhao, Z., Yang, G., Wang, J., Zhu, F., Xue, G., Gao, F., Liu, Y., & Fan, H. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157441 · Cited by 6 · see citing works
Selected Aspects of the Intricate Background of Immune-Related Cholangiopathies—A Critical Overview
Kasztelan‐Szczerbińska, B., Rycyk, A., Szczerbińska, A., & Cichoż‐Lach, H. (2023) · Nutrients · doi:10.3390/nu15030760 · Cited by 6 · see citing works
Ursodeoxycholic acid relieves clinical severity of COVID-19 in patients with chronic liver diseases
Hu, T., Tong, J., Yang, Y., Yuan, C., Zhang, J., & Wang, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1494248 · Cited by 3 · see citing works
Poch, T., Bahn, J., Casar, C., Krause, J., Evangelakos, I., Giladi, H., Kunzmann, L., Laschtowitz, A., Iuso, N., Schäfer, A.-M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101620 · Cited by 3 · see citing works
Bile acid therapy for primary biliary cholangitis: Pathogenetic validation
Reshetnyak, V. I., & Maev, I. V. (2024) · World Journal of Experimental Medicine · doi:10.5493/wjem.v15.i1.101771 · Cited by 3 · see citing works
Zeng, J., Wu, L., Xie, H., Liu, W., Shen, N., & Luo, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-16348-z · Cited by 2 · see citing works
Wang, X., Song, X., Ding, H., Liu, Z., Deng, F., Yan, H., & Yu, B. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.71249 · Cited by 1 · see citing works
Yang, X., Qin, H., Ling, J., Dong, L., Jiang, Y., Zou, S., & Hu, N. (2026) · Bioanalysis · doi:10.1080/17576180.2026.2625865 · Cited by 1 · see citing works
Navigating the liver landscape: upcoming pharmacotherapies for primary sclerosing cholangitis
Pham, H. N., Pham, L., & Sato, K. (2024) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2024.2362263 · Cited by 1 · see citing works
Panuganti, V. K., Alluri, C. V., Dundigalla, M. R., Mohammad, J., Madala, P. K., & V., S. K. S. S. V. (2025) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/adpp/6613969 · Cited by 1 · see citing works
Zhu, C., Boucheron, N., Rîca, R., Stolz, V., Halilbasic, E., Claudel, T., Al-Rubaye, O., Lercher, A., Baumgartner, M., Sandner, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.10.479975 · Cited by 1 · see citing works
Immunology of Autoimmune Liver Diseases
Kayani, K., Bozward, A. G., Davies, S. P., Jeyaraj, R., Asif, A., & Oo, Y. H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00173-3
Keszei, Z., Richter, F. C., Colaço, H. G., Baumgartner, M., Antonio-Herrera, L., Siller, M., Hofmann, A., Viczenczová, C., Baazim, H., Fuchs, C. D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.17.670599
Heeren, J., Evangelakos, I., Verkade, E., Kuipers, F., Rohde, J. S., Heine, M., Worthmann, A., Graute, S., Fuh, M. M., Gunasekaran, K., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-8280795/v1
Dignus, P., Albert, J., Hengstler, J. G., & Trautwein, C. (2026) · Die Gastroenterologie · doi:10.1007/s11377-025-00953-5
Immunpathogenese und Therapie der Primär Sklerosierenden Cholangitis
Zecher, B. F., & Schramm, C. (2026) · Zeitschrift für Gastroenterologie · doi:10.1055/a-2730-4719
Evangelakos, I., Verkade, E., Rohde, J. K., Zaufel, A., Vargek, M., Heine, M., Worthmann, A., Graute, S., Fuh, M. M., Gunasekaran, K., et al. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102363
Primary sclerosing cholangitis: Time to rethink imaging criteria for early disease detection
Schramm, C., Poetter‐Lang, S., Halilbasic, E., Ba‐Ssalamah, A., Trauner, M., Bergquist, A., Ringe, K. I., Grigoriadis, A., & Lemoinne, S. (2026) · Journal of Hepatology · doi:10.1016/j.jhep.2026.04.009
Nor-ursodeoxycholic acid in hepatobiliary diseases: A narrative review
Malakar, S., Sood, N., Giri, S., & Samanta, A. (2026) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.120122
Richter, F. C., Keszei, Z., Viczenczová, C., Baumgartner, M., Colaço, H. G., Siller, M., Holnsteiner, L., Baazim, H., Hofmann, A., Burrett, A., et al. (2026) · JCI Insight · doi:10.1172/jci.insight.189882
Advances in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis
Sandhu, S., & Goel, A. (2026) · Seminars in Liver Disease · doi:10.1055/a-2952-2261
Bile acid signaling in health and disease
Fan, Z., He, M., Liang, T., 张必利, Zhao, N., & Li, P. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00603-4
Wang, X., Zhang, T., Ren, Z., & Ju, B. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1972466
Zhu, H., Chen, H., Gong, Q., Chen, Z., Zhang, C., Xu, J., & Wang, T. (2026) · Medicinal Research Reviews · doi:10.1002/med.70116
Gut Microbiota-Induced Metabolic Reprogramming of the Host Immune System
Roy, S. (2026) · Springer eBooks · doi:10.1007/978-3-032-30306-6_7
- Authors
- Zhu, C., Boucheron, N., Müller, A. C., Májek, P., Claudel, T., Halilbasic, E., Baazim, H., Lercher, A., Viczenczova, C., Hainberger, D., Preglej, T., Sandner, L., Alteneder, M., Gülich, A. F., Khan, M., Hamminger, P., Remetic, J., Ohradanova-Repic, A., Schatzlmaier, P., Donner, C., Fuchs, C. D., Stojakovic, T., Scharnagl, H., Sakaguchi, S., Weichhart, T., Bergthaler, A., Stockinger, H., Ellmeier, W., & Trauner, M.
- Affiliations
- Medical University of Vienna (AT)
- Austrian Academy of Sciences (AT)
- Medical University of Graz (AT)
- Corresponding author
- Boucheron, Nicole
- Trauner, Michael
- ORCID
- Zhu, Ci
- Boucheron, Nicole
- Müller, André C.
- Claudel, Thierry
- Halilbasic, Emina
- Baazim, Hatoon
- Lercher, Alexander
- Hainberger, Daniela
- Preglej, Teresa
- Sandner, Lisa
- Alteneder, Marlis
- Khan, Matarr
- Ohradanova-Repic, Anna
- Schatzlmaier, Philipp
- Fuchs, Claudia D.
- Scharnagl, Hubert
- Sakaguchi, Shinya
- Weichhart, Thomas
- Bergthaler, Andreas
- Stockinger, Hannes
- Ellmeier, Wilfried
- Trauner, Michael
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 75
- Issue
- 5
- Pages
- 1164-1176
- ISSN
- 0168-8278 (ISSN-L)
- PMC
- PMC8522806
- OpenAlex
- W3180833467
- Cited by
- 65
- References
- 34
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 18 · 2023: 11 · 2022: 6 · 2021: 1
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Hepatology (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Austrian Science Fund (DK-IAI W1212, F3517, F7004, F7005, F7310, I2755, P24265, P26193, P27747, P29790, P30885)
- Horizon 2020 (677006)
- Horizon 2020 Framework Programme (683356-FOLSMART)
- European Research Council
- Österreichischen Akademie der Wissenschaften
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- primary sclerosing cholangitis, CD8+ T cells, immunometabolism, mTORC1 signaling, liver inflammation, cholestasis, lymphocytic choriomeningitis virus, bile acids, immune-mediated liver disease, T cell differentiation
- MeSH terms
- Animals, Disease Models, Animal, Inflammation, Liver, Mice, Inbred C57BL, Ursodeoxycholic Acid, CD8-Positive T-Lymphocytes, Mice
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