Cited by 23Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

In vitro efficacy of liposomal amphotericin B, micafungin and fluconazole against non-albicans Candida species biofilms

Kawai, Akira, Yamagishi, Yuka, Mikamo, Hiroshige·2015·Journal of Infection and Chemotherapy

Abstract

Non-albicans Candida species are being isolated with increasing frequency. In this study, biofilm formation by Candida tropicalis, Candida parapsilosis and Candida glabrata was evaluated and the activities of liposomal amphotericin B (LAB), micafungin (MFG) and fluconazole (FLC) against these biofilms were assessed using a clinically relevant in vitro model system. LAB exhibited strong activities against the three non-albicans Candida species and showed dose-dependent efficacy. MFG displayed a paradoxical growth effect against the C. tropicalis biofilm. FLC was ineffective for non-albicans biofilms. This study shows that Candida biofilms have unique susceptibility to LAB. The dose-dependent effects of LAB indicate that this drug may be a useful treatment for biofilm formation by non-albicans Candida species in cases in which the catheter cannot be removed for clinical reasons.

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Crossref · 10.1016/j.jiac.2015.05.007

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36 of 36 references verified0 citation errors · 0 not checkable

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  • Both C. albicans and C. glabrata can form biofilms on abiotic substrates, especially medical devices including catheters and implanted materials.

    “Both C. albicans and C. glabrata can form biofilms on abiotic substrates, especially medical devices including catheters and implanted materials [26,27].”

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Authors
Kawai, A., Yamagishi, Y., & Mikamo, H.
Affiliations
Aichi Medical University (JP)
Corresponding author
Mikamo, Hiroshige
Venue
Journal of Infection and Chemotherapy
Publisher
Elsevier BV
Published
2015-09
Volume
21
Issue
9
Pages
647-653
ISSN
1341-321X (ISSN-L)
OpenAlex
W1903085608
Cited by
23
References
36
Citations by year
2025: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 1
FWCI
2.33
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Infection and Chemotherapy (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
non-albicans Candida, Candida biofilms, liposomal amphotericin B, micafungin, fluconazole, Candida tropicalis, Candida parapsilosis, Candida glabrata, antifungal susceptibility
MeSH terms
Micafungin, Amphotericin B, Antifungal Agents, Microbial Sensitivity Tests, Fluconazole, Biofilms, Candida tropicalis, Candida glabrata, Echinocandins, Lipopeptides, In Vitro Techniques

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