National surveillance of species distribution in blood isolates of candida species in Japan and their susceptibility to six antifungal agents including voriconazole and micafungin

Takakura, S.

doi:10.1093/jac/dkh053

Cited by 117Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Plant Pathogen Control

National surveillance of species distribution in blood isolates of candida species in Japan and their susceptibility to six antifungal agents including voriconazole and micafungin

Takakura, S.·2004·Journal of Antimicrobial Chemotherapy

DOI 10.1093/jac/dkh053

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Abstract

OBJECTIVES: The aim of this study was to evaluate species distribution and antifungal susceptibility of Candida blood isolates in Japan. METHODS: In a 1 year surveillance programme, 535 Candida blood isolates were collected. Identification of species was followed by examination with the broth microdilution method, as described in NCCLS M27-A2, of antifungal susceptibility to six agents, including voriconazole and micafungin, with readings after 24 and 48 h of incubation. RESULTS: The overall species distribution was: 41% Candida albicans, 23% Candida parapsilosis, 18% Candida glabrata, 12% Candida tropicalis and 2% Candida krusei. The concentrations of fluconazole necessary to inhibit 90% of the isolates (MIC(90)) at 24/48 h were 0.25/1 mg/L for C. albicans, 0.5/2 mg/L for C. parapsilosis, 4/32 mg/L for C. glabrata and 4/>128 mg/L for C. tropicalis. Percentages of fluconazole resistance were 1.8% for C. albicans, 0.8% for C. parapsilosis, 5.2% for C. glabrata and 3.2% for C. tropicalis, taking the tendency of trailing growth of C. tropicalis into account. MIC(90) of voriconazole was 0.5 mg/L, although 35% of isolates less susceptible (>/=16 mg/L) to fluconazole showed resistance (>/=2 mg/L). Micafungin was very active against all species (MIC(90), 0.03 mg/L) except for C. parapsilosis (MIC(90), 2 mg/L). CONCLUSIONS: These data suggest that, in Japan, the species distribution of Candida bloodstream infections and the fluconazole resistance rate are similar to those reported previously in North America and Europe. Voriconazole and micafungin appear to have strong in vitro activity against Candida blood isolates, although continuing surveillance and further clinical research are needed.

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In Japan, a national surveillance spanning 105 hospitals reported data for a single year, 2002.
“In Japan, a national surveillance, which spanned 105 participating hospitals, reported data for a single year, 2002.10”
From Distribution, trends, and antifungal susceptibility ofCandidaspecies causing candidemia in Japan, 2010–2019: A retrospective observational study based on national surveillance data (2022) · cites this paper as [10]

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Authors: Takakura, S.
Affiliations: Kyoto University (JP)
Corresponding author: Takakura, S.
Venue: Journal of Antimicrobial Chemotherapy
Publisher: Oxford University Press (OUP)
Published: 2004-01-16
Volume: 53
Issue: 2
Pages: 283-289
ISSN: 0305-7453 (ISSN-L)
1460-2091
DOI: 10.1093/jac/dkh053
OpenAlex: W1994674989
Cited by: 117
References: 36
Citations by year: 2025: 3 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 8 · 2014: 8 · 2013: 2 · 2012: 6
FWCI: 6.56
Type: journal article
Language: en
Open access: closed
Locations: Journal of Antimicrobial Chemotherapy (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Pfizer Pharmaceuticals
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords: Candida species distribution, bloodstream candidiasis, antifungal susceptibility, fluconazole resistance, voriconazole, micafungin, Candida albicans, Candida parapsilosis, Candida glabrata, Candida tropicalis, Candida krusei, antifungal resistance surveillance, Japan
MeSH terms: Micafungin, Amphotericin B, Antifungal Agents, Candida, Candidiasis, Flucytosine, Humans, Japan, Lipoproteins, Microbial Sensitivity Tests, Peptides, Cyclic, Pyrimidines, Triazoles, Itraconazole, Echinocandins, Lipopeptides, Voriconazole

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National surveillance of species distribution in blood isolates of candida species in Japan and their susceptibility to six antifungal agents including voriconazole and micafungin

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