Oral supplementation with cocoa extract reduces UVB-Induced wrinkles in hairless mouse skin
Open accessAbstract
Cacao beans contain various bioactive phytochemicals that could modify the pathogeneses of certain diseases. Here, we report that oral administration of cacao powder (CP) attenuates UVB-induced skin wrinkling by the regulation of genes involved in dermal matrix production and maintenance. Transcriptome analysis revealed that 788 genes are down- or upregulated in the CP supplemented group, compared with the UVB-irradiated mouse skin controls. Among the differentially expressed genes, cathepsin G and serpin B6c play important roles in UVB-induced skin wrinkle formation. Gene regulatory network analysis also identified several candidate regulators responsible for the protective effects of CP supplementation against UVB-induced skin damage. CP also elicited antiwrinkle effects via inhibition of UVB-induced matrix metalloproteinases-1 expression in both the human skin equivalent model and human dermal fibroblasts. Inhibition of UVB-induced activator protein-1 via CP supplementation is likely to affect the expression of matrix metalloproteinases-1. CP supplementation also downregulates the expression of cathepsin G in human dermal fibroblasts. 5-(3',4'-Dihydroxyphenyl)-γ-valerolactone, a major in vivo metabolite of CP, showed effects similar to CP supplementation. These results suggest that cacao extract may offer a protective effect against photoaging by inhibiting the breakdown of dermal matrix, which leads to an overall reduction in wrinkle formation.
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Oral administration of cacao powder attenuated UVB-induced mouse dorsal skin wrinkling by reduction of MMP-1 via the MAPK pathway and downregulation of cathepsin G gene expression in SKH-1 mice and a 3D skin model.
“Oral administration of cacao powder was able to attenuate UVB-induced mouse dorsal skin wrinkling by the reduction of MMP-1 via the MAPK pathway and the downregulation of the gene expression of cathepsin G in SKH-1 mice and a 3D skin model [116].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [116]
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- Authors
- Kim, J.-E., Song, D., Kim, J., Choi, J., Kim, J. R., Yoon, H.-S., Bae, J.-S., Han, M., Lee, S., Hong, J. S., Song, D., Kim, S.-J., Son, M.-J., Choi, S.-W., Chung, J. H., Kim, T.-A., & Lee, K. W.
- Affiliations
- Seoul National University (KR)
- CHA University (KR)
- Corresponding author
- Kim, Tae-Aug
- Lee, Ki Won
- ORCID
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 136
- Issue
- 5
- Pages
- 1012-1021
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2253217690
- Cited by
- 37
- References
- 56
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 8 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 3
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Trade, Industry and Energy (N0000697)
- Korea Institute for Advancement of Technology
- Ministry of Education, Science and Technology
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- cocoa extract, UVB-induced skin damage, photoaging, wrinkles, dermal extracellular matrix, cathepsin G, MMP-1, activator protein-1, gene regulatory networks, transcriptome, dermal fibroblasts, skin equivalent model, oral supplementation
- MeSH terms
- Administration, Oral, Analysis of Variance, Animals, Cacao, Collagen, Disease Models, Animal, Female, Gene Expression Regulation, Humans, Mice, Hairless, Plant Extracts, Random Allocation, Sensitivity and Specificity, Ultraviolet Rays, Skin Aging, Up-Regulation, Transcription Factor AP-1, Dietary Supplements, Matrix Metalloproteinase 1, Mice
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