The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Temporal Stability in Chronic Wound Microbiota Is Associated With Poor Healing
Open accessAbstract
Microbial burden of chronic wounds is believed to play an important role in impaired healing and development of infection-related complications. However, clinical cultures have little predictive value of wound outcomes, and culture-independent studies have been limited by cross-sectional design and small cohort size. We systematically evaluated the temporal dynamics of the microbiota colonizing diabetic foot ulcers (DFU), a common and costly complication of diabetes, and its association with healing and clinical complications. Dirichlet multinomial mixture modeling, Markov chain analysis, and mixed-effect models were used to investigate shifts in the microbiota over time and its associations with healing. Here we show to our knowledge previously unreported temporal dynamics of the chronic wound microbiome. Microbiota community instability was associated with faster healing and improved outcomes. DFU microbiota were found to exist in one of four community types that experienced frequent and non-random transitions. Transition patterns and frequencies associated with healing time. Exposure to systemic antibiotics destabilized the wound microbiota, rather than altering overall diversity or relative abundance of specific taxa. This study provides to our knowledge previously unreported evidence that the dynamic wound microbiome is indicative of clinical outcomes and may be a valuable guide for personalized management and treatment of chronic wounds.
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Cited by
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Self-citationSkin microbiota–host interactions
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Challenges in exploring and manipulating the human skin microbiome
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Multistage ROS-Responsive and Natural Polyphenol-Driven Prodrug Hydrogels for Diabetic Wound Healing
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Metadata
- Authors
- Loesche, M., Gardner, S. E., Kalan, L., Horwinski, J., Zheng, Q., Hodkinson, B. P., Tyldsley, A. S., Franciscus, C. L., Hillis, S. L., Mehta, S., Margolis, D. J., & Grice, E. A.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 137
- Issue
- 1
- Pages
- 237-244
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W2513592334
- Cited by
- 310
- References
- 12
- FWCI
- 18.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Loesche, M., Gardner, S. E., Kalan, L., Horwinski, J., Zheng, Q., Hodkinson, B. P., Tyldsley, A. S., Franciscus, C. L., Hillis, S. L., Mehta, S., Margolis, D. J., & Grice, E. A. (2017). Temporal Stability in Chronic Wound Microbiota Is Associated With Poor Healing. Journal of Investigative Dermatology. https://doi.org/10.1016/j.jid.2016.08.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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