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Cited by 38Endometriosis Research and TreatmentInflammatory Biomarkers in Disease PrognosisEndometrial and Cervical Cancer Treatments

Noninvasive Diagnosis of Moderate to Severe Endometriosis: The Platelet-Lymphocyte Ratio Cannot Be a Neoadjuvant Biomarker for Serum Cancer Antigen 125

Yang, Hua, Zhu, Lan, Wang, Shu, Lang, Jinghe, Xu, Tao·2015·Journal of Minimally Invasive Gynecology
DOI 10.1016/j.jmig.2013.06.003
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Abstract

Study objective To investigate whether the combined value of the platelet-lymphocyte ratio (PLR) and serum cancer antigen 125 (CA 125) can be used in diagnosing moderate to severe endometriosis.Design A retrospective study (Canadian Task Force classification II-2).Setting A single center (Department of Obstetrics and Gynecology, Physical Examination Center of Peking Union Medical College Hospital, Beijing, China).Patients Two hundred ninety-nine premenopausal women who underwent laparoscopic surgery, 197 patients with moderate to severe endometriosis, 102 patients with benign tumor, and 112 healthy subjects.Interventions None.Main outcome measures Analyses were performed using 1-way analysis of variance and receiver operating characteristic (ROC) curves.Results The mean absolute value of serum CA 125, PLR, and the combination values were significantly increased for patients in the moderate to severe endometriosis group (p = .000, p = .004, p = .009, respectively). The area under the curve (AUC) for CA 125 was 0.943 (95% confidence interval [CI], 0.918-0.967) with a sensitivity and specificity of 71.6% and 99.1%, respectively. The AUC for PLR was 0.587 (95% CI, 0.520-0.653) with a sensitivity of 65.0%, a specificity of 51.8%, and a cutoff value at 117.16. The combination, which was calculated by multiplying CA 125 levels by the PLR, with an AUC of 0.929 (95% CI, 0.900-0.958) and a cutoff value of 2812.40, showed the highest sensitivity of 90.4% but a lower specificity of 84.8%.Conclusion Serum CA 125 is better than the PLR and the combination biomarkers in diagnosing moderate to severe endometriosis.

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Crossref · 10.1016/j.jmig.2013.06.003

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  • For none of the cell populations including T cells, B cells, NK cells, macrophages/monocytes, and polymorphonuclear neutrophils has utility as an endometriosis biomarker been proven.

    “A range of cell populations, including T cells, B cells, natural killer (NK) cells, macrophages/monocytes, and polymorphonuclear neutrophils, has been compared between endometriosis patients and healthy controls [23]. However, for none of these populations the utility as an endometriosis biomarker has been proven [23, 96].”

    From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [96]

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Authors
Yang, H., Zhu, L., Wang, S., Lang, J., & Xu, T.
Affiliations
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author
Zhu, Lan
ORCID
Venue
Journal of Minimally Invasive Gynecology
Publisher
Elsevier BV
Published
2015-03
Volume
22
Issue
3
Pages
373-377
ISSN
1553-4650 (ISSN-L)
DOI
10.1016/j.jmig.2013.06.003
OpenAlex
W1968124807
Cited by
37
References
26
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 3
FWCI
3.62
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Minimally Invasive Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords
endometriosis, platelet-to-lymphocyte ratio, CA125, serum biomarkers, non-invasive diagnosis, premenopausal women, sensitivity and specificity
MeSH terms
Adult, China, Endometriosis, Female, Humans, Leiomyoma, Lymphocytes, Neutrophils, Platelet Count, Predictive Value of Tests, Retrospective Studies, ROC Curve, Sensitivity and Specificity, Severity of Illness Index, Biomarkers, CA-125 Antigen, Lymphocyte Count

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