Regulatory T cells and other leukocytes in the pathogenesis of endometriosis

Berbic, M.; Fraser, I.S.

doi:10.1016/j.jri.2010.11.004

Cited by 135Endometriosis Research and TreatmentReproductive System and PregnancyEctopic Pregnancy Diagnosis and Management

Regulatory T cells and other leukocytes in the pathogenesis of endometriosis

Berbic, M., Fraser, I.S.·2011·Journal of Reproductive Immunology

DOI 10.1016/j.jri.2010.11.004

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Abstract

Endometriosis is a common and puzzling gynaecological condition which shows a great deal of variability between women. It affects up to 15% of all women of reproductive age. There is a strong familial component, but the aetiology and pathogenesis are still uncertain. Endometriosis is an 'inflammatory' condition with substantial numbers of leukocytes recruited into the lesion sites. There is increasing evidence to demonstrate marked changes in numbers and functions of these leukocytes in the eutopic endometrium and peritoneal fluid as well as in the lesions. We hypothesise that endometriosis is primarily an endometrial disease with underlying genetic disturbances which lead to a number of major molecular changes in function, enhancing the likelihood that viable fragments of endometrial tissue will pass through the fallopian tubes and attach and grow on the peritoneum. We have demonstrated disturbances in the populations of T cells, B cells, mast cells, dendritic cells and macrophages within the endometrium and ectopic lesions, and are intrigued by the potential for changes in regulatory T cells to influence disease establishment and progression. Interestingly, we have shown that in endometriosis, naturally occurring FOXP3+ regulatory T cells fail to undergo the expected decline in number during the secretory phase, which may account for a decreased ability of newly recruited leukocytes to initiate effective immune responses against viable endometrial fragments, permitting their survival and subsequent establishment. To better understand the pathogenesis of endometriosis, we must learn about how the immune system recognises this disease and how the endometrial immune response is regulated.

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There is increasing evidence for marked changes in numbers and functions of leukocytes in eutopic endometrium, peritoneal fluid, and endometriotic lesions.
“There is increasing evidence for marked changes in numbers and functions of leukocytes in the eutopic endometrium, peritoneal fluid, and in endometriotic lesions.68”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [68]

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Higher frequency of circulating, but not tissue regulatory T cells in patients with endometriosis
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Authors: Berbic, M., & Fraser, I. S.
Affiliations: The University of Sydney (AU)
Corresponding author: Fraser, I.S.
Venue: Journal of Reproductive Immunology
Publisher: Elsevier BV
Published: 2011-03
Volume: 88
Issue: 2
Pages: 149-155
ISSN: 0165-0378 (ISSN-L)
DOI: 10.1016/j.jri.2010.11.004
OpenAlex: W2048798995
Cited by: 135
References: 52
Citations by year: 2026: 3 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 12 · 2019: 4 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 14 · 2014: 14 · 2013: 15 · 2012: 8
FWCI: 15.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Reproductive Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords: endometriosis, regulatory T cells, Foxp3, leukocyte recruitment, endometrial immune response, mast cells, dendritic cells, macrophages, B cells, peritoneal fluid, luteal phase, ectopic endometrium, pathogenesis
MeSH terms: Animals, Choristoma, Endometriosis, Endometrium, Female, Humans, Inflammation, Pregnancy, Pregnancy, Ectopic, Uterus, T-Lymphocytes, Regulatory, Forkhead Transcription Factors

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Regulatory T cells and other leukocytes in the pathogenesis of endometriosis

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