Potential involvement of iron in the pathogenesis of peritoneal endometriosis

Defrere, S.; Lousse, J.C.; Gonzalez-Ramos, R.; Colette, S.; Donnez, J.; Van Langendonckt, A.

doi:10.1093/molehr/gan033

Cited by 204Endometriosis Research and TreatmentIron Metabolism and DisordersEctopic Pregnancy Diagnosis and Management

Potential involvement of iron in the pathogenesis of peritoneal endometriosis

Defrere, S., Lousse, J.C., Gonzalez-Ramos, R., Colette, S., Donnez, J., Van Langendonckt, A.·2008·Molecular Human Reproduction

DOI 10.1093/molehr/gan033

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Abstract

The aim of this study is to review the current literature associating endometriosis with iron and to discuss the potential causes and consequences of iron overload in the pelvic cavity. Indeed, iron is essential for all living organisms. However, excess iron can result in toxicity and is associated with pathological disorders. In endometriosis patients, iron overload has been demonstrated in the different components of the peritoneal cavity (peritoneal fluid, endometriotic lesions, peritoneum and macrophages). Animal models allow us to gather essential information on the origin, metabolism and effect of iron overload in endometriosis, which may originate from erythrocytes carried into the pelvic cavity mainly by retrograde menstruation. Peritoneal macrophages play an important role in the degradation of these erythrocytes and in subsequent peritoneal iron metabolism. Iron overload could affect a wide range of mechanisms involved in endometriosis development, such as oxidative stress or lesion proliferation. In conclusion, excess iron accumulation can result in toxicity and may be one of the factors contributing to the development of endometriosis. Treatment with an iron chelator could thus be beneficial in endometriosis patients to prevent iron overload in the pelvic cavity, thereby diminishing its deleterious effect.

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Endometriosis also occurs in patients after menopause and in adolescent women.
“However, it should be noted that there are also cases of patients with endometriosis after menopause, and it also happens in adolescent women [17].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [17]
Endometriosis affects 10-15% of women of reproductive age and 35-50% of women with pelvic pain and/or infertility.
“This disease affects from 10–15% of women of reproductive age and 35–50% of women with pelvic pain and/or infertility.”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [17]

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Authors: Defrere, S., Lousse, J. C., Gonzalez-Ramos, R., Colette, S., Donnez, J., & Van Langendonckt, A.
Affiliations: Cliniques Universitaires Saint-Luc (BE)
ORCID: Donnez, J.
Venue: Molecular Human Reproduction
Publisher: Oxford University Press (OUP)
Published: 2008-05-28
Volume: 14
Issue: 7
Pages: 377-385
ISSN: 1360-9947 (ISSN-L)
1460-2407
DOI: 10.1093/molehr/gan033
OpenAlex: W2119501943
Cited by: 204
References: 127
Citations by year: 2026: 14 · 2025: 26 · 2024: 20 · 2023: 18 · 2022: 15 · 2021: 12 · 2020: 10 · 2019: 7 · 2018: 4 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 7 · 2013: 9 · 2012: 13
FWCI: 1.02
Type: journal article
Language: en
Open access: closed
Locations: Molecular Human Reproduction (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (submittedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords: endometriosis, iron overload, peritoneal endometriosis, peritoneal macrophages, peritoneal fluid, retrograde menstruation, oxidative stress, iron chelation, iron metabolism, pathogenesis
MeSH terms: Animals, Endometriosis, Female, Humans, Iron, Models, Biological, Peritoneum, Oxidative Stress, Iron Overload

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Potential involvement of iron in the pathogenesis of peritoneal endometriosis

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